Crystal structure of the putative cyclase IdmH from the indanomycin nonribosomal peptide synthase/polyketide synthase

Autor: Ieva Drulyte, Jana Obajdin, Chi H. Trinh, Arnout P. Kalverda, Marc W. van der Kamp, Glyn R. Hemsworth, Alan Berry

Publikováno v: IUCrJ, Vol 6, Iss 6, Pp 1120-1133 (2019)

Indanomycin is biosynthesized by a hybrid nonribosomal peptide synthase/polyketide synthase (NRPS/PKS) followed by a number of `tailoring' steps to form the two ring systems that are present in the mature product. It had previously been hypothesized

Externí odkaz: https://doaj.org/article/1d7033a8f6d9495181411cd7ea98934b

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Programmed Iteration Controls the Assembly of the Nonanoic Acid Side Chain of the Antibiotic Mupirocin

Autor: Ashley J. Winter, Matthew T. Rowe, Angus N. M. Weir, Nahida Akter, Sbusisiwe Z. Mbatha, Paul D. Walker, Christopher Williams, Zhongshu Song, Paul R. Race, Christine L. Willis, Matthew P. Crump

Publikováno v: Winter, A J, Rowe, M T, Weir, A N M, Akter, N, Mbatha, S Z, Walker, P D, Williams, C, Song, Z, Race, P R, Willis, C L & Crump, M P 2022, ' Programmed Iteration Controls the Assembly of the Nonanoic Acid Side Chain of the Antibiotic Mupirocin ', Angewandte Chemie-International Edition, vol. 61, no. 50, e202212393 . https://doi.org/10.1002/anie.202212393

Mupirocin is a clinically important antibiotic produced by Pseudomonas fluorescens NCIMB 10586 that is assembled by a complex trans-AT polyketide synthase. The polyketide fragment, monic acid, is esterified by a 9-hydroxynonanoic acid (9HN) side chai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8f3287f7bbdf8f76bb39e10e426174f
https://pubmed.ncbi.nlm.nih.gov/36227272

Synthesis of complex intermediates for the study of a dehydratase from borrelidin biosynthesis

Autor: Frank Hahn, Nadine Kandziora, Steffen Friedrich, Peter F. Leadlay

Publikováno v: Beilstein Journal of Organic Chemistry, Vol 10, Iss 1, Pp 634-640 (2014)

Herein, we describe the syntheses of a complex biosynthesis-intermediate analogue of the potent antitumor polyketide borrelidin and of reference molecules to determine the stereoselectivity of the dehydratase of borrelidin polyketide synthase module

Externí odkaz: https://doaj.org/article/20ff2f6e2bd74a97b8b638fd553ba675

A bio-inspired cell-free system for cannabinoid production from inexpensive inputs

Autor: Tyler P. Korman, Mark A. Arbing, James U. Bowie, Meaghan Valliere

Publikováno v: Nature Chemical Biology. 16:1427-1433

Moving cannabinoid production away from the vagaries of plant extraction and into engineered microbes could provide a consistent, purer, cheaper and environmentally benign source of these important therapeutic molecules, but microbial production face

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b28a8e60a650de70e6b3412845590074
https://doi.org/10.1038/s41589-020-0631-9