Zobrazeno 1 - 10
of 9 168
pro vyhledávání: '"polygenic risk"'
Autor:
Stearns, Stephen C., author, Medzhitov, Ruslan, author
Publikováno v:
Evolutionary Medicine, 2024, ill.
Externí odkaz:
https://doi.org/10.1093/oso/9780192871978.003.0015
Autor:
Sheng-Chun Hung, Li-Wen Chang, Tzu-Hung Hsiao, Chia-Yi Wei, Shian-Shiang Wang, Jian-Ri Li, I-Chieh Chen
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Although prostate cancer is a common occurrence among males, the relationship between existing risk prediction models remains unclear. The objective of this hospital-based retrospective study is to investigate the impact of polygenic risk sc
Externí odkaz:
https://doaj.org/article/8def721121954e0caca97dbc64eaaddf
Autor:
Dayeon Shin
Publikováno v:
BMC Medical Genomics, Vol 17, Iss 1, Pp 1-14 (2024)
Abstract Introduction Metabolic syndrome is a chronic disease associated with multiple comorbidities. Over the last few years, machine learning techniques have been used to predict metabolic syndrome. However, studies incorporating demographic, clini
Externí odkaz:
https://doaj.org/article/88651f35e24a4260bd4ec819afef2368
Autor:
Yu Zhang, Chao Sheng, Zhangyan Lyu, Hongji Dai, Fangfang Song, Fengju Song, Yubei Huang, Kexin Chen
Publikováno v:
Cancer Biology & Medicine, Vol 21, Iss 8, Pp 712-723 (2024)
Objective: Few studies have evaluated the benefits of colorectal cancer (CRC) screening integrating both non-genetic and genetic risk factors. Here, we aimed to integrate an existing non-genetic risk model (QCancer-10) and a 139-variant polygenic ris
Externí odkaz:
https://doaj.org/article/978bfc13fc3d46bfa52245841d44af5d
Autor:
Kira Trares, Hannah Stocker, Joshua Stevenson-Hoare, Laura Perna, Bernd Holleczek, Konrad Beyreuther, Ben Schöttker, Hermann Brenner
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-12 (2024)
Abstract Background Polygenic risk scores (PRS) and subjective cognitive decline (SCD) are associated with the risk of developing dementia. It remains to examine whether they can improve the established cardiovascular risk factors aging and dementia
Externí odkaz:
https://doaj.org/article/2dd30935939c4e65bc30c566b652366b
Autor:
Mohammad Dehestani, Velina Kozareva, Cornelis Blauwendraat, Ernest Fraenkel, Thomas Gasser, Vikas Bansal
Publikováno v:
Molecular Brain, Vol 17, Iss 1, Pp 1-10 (2024)
Abstract Several prior studies have proposed the involvement of various brain regions and cell types in Parkinson’s disease (PD) pathology. Here, we performed snRNA-seq on the prefrontal cortex and anterior cingulate regions from a small cohort of
Externí odkaz:
https://doaj.org/article/eed45c239e5848d1b734879955c3654e
Impact of hyperuricemia on CKD risk beyond genetic predisposition in a population-based cohort study
Autor:
Yaerim Kim, Jinyeon Jo, Yunmi Ji, Eunjin Bae, Kwangbae Lee, Jin Hyuk Paek, Kyubok Jin, Seungyeup Han, Jung Pyo Lee, Dong Ki Kim, Chun Soo Lim, Sungho Won, Jeonghwan Lee
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract The bidirectional effect of hyperuricemia on chronic kidney disease (CKD) underscores the importance of hyperuricemia as a risk factor for CKD. We evaluated the effect of hyperuricemia on the presence and development of CKD after considering
Externí odkaz:
https://doaj.org/article/afd470aa36ce4b3db2903e67be88a767
Autor:
Salahuddin Mohammad, Mélissa Gentreau, Manon Dubol, Gull Rukh, Jessica Mwinyi, Helgi B. Schiöth
Publikováno v:
Molecular Autism, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Previous research on autism spectrum disorders (ASD) have showed important volumetric alterations in the cerebellum and brainstem. Most of these studies are however limited to case-control studies with small clinical samples and including ma
Externí odkaz:
https://doaj.org/article/2a62513784754a00909ba7e176f81443
Autor:
Jamil Alenbawi, Yasser A. Al-Sarraj, Umm-Kulthum I. Umlai, Ayat Kadhi, Nagham N. Hendi, Georges Nemer, Omar M. E. Albagha
Publikováno v:
Human Genomics, Vol 18, Iss 1, Pp 1-12 (2024)
Abstract Sitosterolemia is a rare inherited disorder caused by mutations in the ABCG5/ABCG8 genes. These genes encode proteins involved in the transport of plant sterols. Mutations in these genes lead to decreased excretion of phytosterols, which can
Externí odkaz:
https://doaj.org/article/4b41350d245544dabc97274275caff03
Autor:
Jiajie Peng, Zhijie Bao, Jingyi Li, Ruijiang Han, Yuxian Wang, Lu Han, Jinghao Peng, Tao Wang, Jianye Hao, Zhongyu Wei, Xuequn Shang
Publikováno v:
Fundamental Research, Vol 4, Iss 4, Pp 752-760 (2024)
The potential for being able to identify individuals at high disease risk solely based on genotype data has garnered significant interest. Although widely applied, traditional polygenic risk scoring methods fall short, as they are built on additive m
Externí odkaz:
https://doaj.org/article/6225a42707df44458a2783098d47734f