Single-Domain Antibodies and the Promise of Modular Targeting in Cancer Imaging and Treatment

Autor: María Elena Iezzi, Lucía Policastro, Santiago Werbajh, Osvaldo Podhajcer, Gabriela Alicia Canziani

Publikováno v: Frontiers in Immunology, Vol 9 (2018)

Monoclonal antibodies and their fragments have significantly changed the outcome of cancer in the clinic, effectively inhibiting tumor cell proliferation, triggering antibody-dependent immune effector cell activation and complement mediated cell deat

Externí odkaz: https://doaj.org/article/31d0174881e947029761ba0141a00831

A New in Silico Antibody Similarity Measure Both Identifies Large Sets of Epitope Binders with Distinct CDRs and Accurately Predicts Off-Target Reactivity

Autor: Astrid Musnier, Thomas Bourquard, Amandine Vallet, Laetitia Mathias, Gilles Bruneau, Mohammed Akli Ayoub, Ophélie Travert, Yannick Corde, Nathalie Gallay, Thomas Boulo, Sandra Cortes, Hervé Watier, Pascale Crépieux, Eric Reiter, Anne Poupon

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, 2022, 23 (17), pp.1-17. ⟨10.3390/ijms23179765⟩
International Journal of Molecular Sciences; Volume 23; Issue 17; Pages: 9765

International audience; Developing a therapeutic antibody is a long, tedious, and expensive process. Many obstacles need to be overcome, such as biophysical properties (issues of solubility, stability, weak production yields, etc.), as well as cross-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::820601cc291909ac2734db5a3b47323c
https://doi.org/10.3390/ijms23179765

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