Autoreactivity and broad neutralization of antibodies against HIV-1 are governed by distinct mutations: Implications for vaccine design strategies

Autor: Xiaojun Li, Dongmei Liao, Zhengyang Li, Jixi Li, Marilyn Diaz, Laurent Verkoczy, Feng Gao

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

Many of the best HIV-1 broadly neutralizing antibodies (bnAbs) known have poly-/autoreactive features that disfavor normal B cell development and maturation, posing a major hurdle in developing an effective HIV-1 vaccine. Key to resolving this proble

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Characteristics of the IgM Repertoires in the Peripheral Blood of Early Rheumatoid Arthritis Patients.

Autor: Hong B; Clinical Laboratory Center, Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian Province, 362018, China.; Key Laboratory of Screening and Control of Infectious Diseases (Quanzhou Medical College), Fujian Provincial University, Quanzhou, 362011, China., Li Q; Clinical Laboratory Center, Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian Province, 362018, China., Liu Q; Clinical Laboratory Center, Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian Province, 362018, China., Huang R; Clinical Laboratory Center, Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian Province, 362018, China., Wang M; Clinical Laboratory Center, Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian Province, 362018, China., Guo Z; Clinical Laboratory Center, Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian Province, 362018, China.; Graduate School, Fujian Medical University, Fuzhou, Fujian Province, 350108, China., Huang J; Clinical Laboratory Center, Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian Province, 362018, China.; Graduate School, Fujian Medical University, Fuzhou, Fujian Province, 350108, China., Wang J; Clinical Laboratory Center, Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian Province, 362018, China.; Graduate School, Fujian Medical University, Fuzhou, Fujian Province, 350108, China., Fan C; Clinical Laboratory Center, Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian Province, 362018, China., Ying T; Key Laboratory of Medical Molecular Virology of Ministries of Education and Health, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China.

Publikováno v: Journal of leukocyte biology [J Leukoc Biol] 2024 Oct 24. Date of Electronic Publication: 2024 Oct 24.