Zobrazeno 1 - 10 of 318 pro vyhledávání: '"poly reactivity"'
1
Akademický článek
Mechanistic Insight into Poly-Reactivity of Immune Antibodies upon Acid Denaturation or Arginine Mutation in Antigen-Binding Regions.
Autor: Arakawa, Tsutomu1 (AUTHOR) tarakawa2@aol.com, Akuta, Teruo2 (AUTHOR) t.akuta@kyokutoseiyaku.co.jp
Publikováno v: Antibodies (2073-4468). Dec2023, Vol. 12 Issue 4, p64. 15p.
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2
Akademický článek
Mechanistic Insight into Poly-Reactivity of Immune Antibodies upon Acid Denaturation or Arginine Mutation in Antigen-Binding Regions
Autor: Tsutomu Arakawa, Teruo Akuta
Publikováno v: Antibodies, Vol 12, Iss 4, p 64 (2023)
The poly-reactivity of antibodies is defined as their binding to specific antigens as well as to related proteins and also to unrelated targets. Poly-reactivity can occur in individual molecules of natural serum antibodies, likely due to their confor
Externí odkaz: https://doaj.org/article/814a9f82b8af4221a5dee5a91e98818b
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4
Chronic lymphocytic leukemia immunoglobulins display bacterial reactivity that converges and diverges from auto-/poly-reactivity and IGHV mutation status
Autor: Charles C. Chu, Jonathan E. Kolitz, Kanti R. Rai, Carolina Moreno Atanasio, Steven L. Allen, Nicholas Chiorazzi, Rosa Catera, Vincent A. Fischetti, Katerina Hatzi
Publikováno v: Clinical Immunology. 172:44-51
Chronic lymphocytic leukemia (CLL) is an incurable leukemia of unknown etiology. Multiple studies suggest that the structure of the variable domains of the surface IGs on these cells, and signaling through them, play key roles in developing the disea
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9405b22abacf2f2338a08a8817466e66
https://doi.org/10.1016/j.clim.2016.08.020
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6
Akademický článek
Autoreactivity and broad neutralization of antibodies against HIV-1 are governed by distinct mutations: Implications for vaccine design strategies
Autor: Xiaojun Li, Dongmei Liao, Zhengyang Li, Jixi Li, Marilyn Diaz, Laurent Verkoczy, Feng Gao
Publikováno v: Frontiers in Immunology, Vol 13 (2022)
Many of the best HIV-1 broadly neutralizing antibodies (bnAbs) known have poly-/autoreactive features that disfavor normal B cell development and maturation, posing a major hurdle in developing an effective HIV-1 vaccine. Key to resolving this proble
Externí odkaz: https://doaj.org/article/f1b9f62a94884170848a23b05e2c571e
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7
Akademický článek
Beyond glycan barriers: non-cognate ligands and protein mimicry approaches to elicit broadly neutralizing antibodies for HIV-1.
Autor: Walimbwa, Stephen Ian1 (AUTHOR) Stephenian.walimbwa01@upol.cz, Maly, Petr2 (AUTHOR), Kafkova, Leona Raskova3 (AUTHOR), Raska, Milan1,3 (AUTHOR) milan.raska@upol.cz
Publikováno v: Journal of Biomedical Science. 8/21/2024, Vol. 31 Issue 1, p1-16. 16p.
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8
Akademický článek
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9
Akademický článek
The Application of Machine Learning on Antibody Discovery and Optimization.
Autor: Zheng, Jiayao1 (AUTHOR), Wang, Yu2 (AUTHOR), Liang, Qianying2 (AUTHOR), Cui, Lun1,2 (AUTHOR) luncui@cczu.edu.cn, Wang, Liqun1 (AUTHOR) luncui@cczu.edu.cn
Publikováno v: Molecules. Dec2024, Vol. 29 Issue 24, p5923. 14p.
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10
Akademický článek
Persistent B-Cell Stimulation or B-Cell Repertoire Anomalies? The Dilemma of the Origin of Chronic Lymphocytic Leukemia (CLL).
Autor: Ferrarini, Manlio1 (AUTHOR) ferrarini.manlio@gmail.com, Bagnara, Davide1 (AUTHOR), Ghiotto, Fabio1,2 (AUTHOR), Fais, Franco1,2 (AUTHOR)
Publikováno v: Lymphatics. Sep2024, Vol. 2 Issue 3, p147-156. 10p.
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