Zobrazeno 1 - 10
of 1 402
pro vyhledávání: '"podocyte injury"'
Autor:
Yepeng Hu, Shu Ye, Jing Kong, Qiao Zhou, Zhe Wang, Yikai Zhang, Han Yan, Yaqiong Wang, Tiekun Li, Yi Xie, Bingbing Chen, Yiming Zhao, Tianyue Zhang, Xianan Zheng, Junjia Niu, Bibi Hu, Shengyao Wang, Zhida Chen, Chao Zheng
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-19 (2024)
Abstract Background Podocyte injury causes proteinuria and accelerates glomerular sclerosis during diabetic kidney disease (DKD). Disruptor of telomeric silencing 1-like (DOT1L), an evolutionarily conserved histone methyltransferase, has been reporte
Externí odkaz:
https://doaj.org/article/4565f6080f804790850958635920346d
Autor:
Yujiao Huang, Jie Geng, Mengdan Wang, Wenbin Liu, Haikun Hu, Wei Shi, Mei Li, Guiyang Huo, Guangrui Huang, Anlong Xu
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Podocytes are specialized terminally differentiated cells in the glomerulus that are the primary target cells in many glomerular diseases. However, the current podocyte cell lines suffer from prolonged in vitro differentiation and limited su
Externí odkaz:
https://doaj.org/article/c024ec4d06e343ed9bf13abf2a98bfcc
Autor:
Bangrui Huang, Rui Han, Hong Tan, Wenzhuo Zhu, Yang Li, Fakun Jiang, Chun Xie, Zundan Ren, Rou Shi
Publikováno v:
Natural Products and Bioprospecting, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Breviscapine, a natural flavonoid mixture derived from the traditional Chinese herb Erigeron breviscapus (Vant.) Hand-Mazz, has demonstrated a promising potential in improving diabetic nephropathy (DN). However, the specific active constitue
Externí odkaz:
https://doaj.org/article/79bc4a1b4efa4b05883696bbfa1809f6
Autor:
Jingjing He, Boxin Liu, Xiaofeng Du, Yan Wei, Desheng Kong, Baofeng Feng, Ruiyun Guo, Ernest Amponsah Asiamah, Matthew D. Griffin, Sean O. Hynes, Sanbing Shen, Yan Liu, Huixian Cui, Jun Ma, Timothy O’Brien
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Background and aims Mesenchymal stromal cells (MSCs) a potentially effective disease-modulating therapy for diabetic nephropathy (DN) but their clinical translation has been hampered by incomplete understanding of the optimal timing of admin
Externí odkaz:
https://doaj.org/article/5d0a65d625d44f7abac7708253ffd38f
Publikováno v:
Renal Failure, Vol 46, Iss 2 (2024)
Background Podocyte injury plays an important role in the occurrence and progression of diabetic kidney disease (DKD), which leads to albuminuria. Cytoskeletal remodeling is an early manifestation of podocyte injury in DKD. However, the underlying me
Externí odkaz:
https://doaj.org/article/b7622f6a02c54b64add13872901e6320
Publikováno v:
Renal Failure, Vol 46, Iss 1 (2024)
Diabetic kidney disease (DKD) is a common chronic microvascular complication of diabetes mellitus. Although studies have indicated the therapeutic potential of mesenchymal stem cells (MSCs) for DKD, the underlying molecular mechanisms remain unclear.
Externí odkaz:
https://doaj.org/article/8b496807dbb442fc9453ecd5d09a7e6c
Autor:
Zhaodi Han, Le Gong, Yani Xue, Rui Wang, Jing Liu, Xinyu Wang, Wenyan Zhao, Hui Liao, Rongshan Li
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
BackgroundPodocyte injury is a common pathologic mechanism in diabetic kidney disease (DKD) and obesity-related glomerulopathy (ORG). Our previous study confirmed that Inonotus obliquus (IO) improved podocyte injury on DKD rats. The current study exp
Externí odkaz:
https://doaj.org/article/47c292c827b14019bc578ee61f137aa9
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
IntroductionIncreasing evidence shows that hyperactive aryl hydrocarbon receptor (AHR) signalling is involved in renal disease. However, no currently available intervention strategy is effective in halting disease progression by targeting the AHR sig
Externí odkaz:
https://doaj.org/article/38d69408b9c9429dbae744a29076478e
Autor:
Yiqun Hao, Yanqin Fan, Jun Feng, Zijing Zhu, Zilv Luo, Hongtu Hu, Weiwei Li, Hongxia Yang, Guohua Ding
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-20 (2024)
Abstract Background Cardiolipin (CL) plays a critical role in maintaining mitochondrial membrane integrity and overall mitochondrial homeostasis. Recent studies have suggested that mitochondrial damage resulting from abnormal cardiolipin remodelling
Externí odkaz:
https://doaj.org/article/5e516b0661344a48b545c52340cca58d
Autor:
Hailin Long, Mengzhen Liu, Zhongchen Rao, Shanyue Guan, Xiaotian Chen, Xiaoting Huang, Li Cao, Richou Han
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 19, p 10352 (2024)
Pharmacogenomic analysis based on drug transcriptome characteristics is widely used to identify mechanisms of action. The purpose of this study was to elucidate the molecular mechanism of protective effect against adriamycin (ADM)-induced mpc5 cell i
Externí odkaz:
https://doaj.org/article/962da166011e4c85a8708a4e596e73f5