Zobrazeno 1 - 10
of 1 419
pro vyhledávání: '"podocyte injury"'
Autor:
Yepeng Hu, Shu Ye, Jing Kong, Qiao Zhou, Zhe Wang, Yikai Zhang, Han Yan, Yaqiong Wang, Tiekun Li, Yi Xie, Bingbing Chen, Yiming Zhao, Tianyue Zhang, Xianan Zheng, Junjia Niu, Bibi Hu, Shengyao Wang, Zhida Chen, Chao Zheng
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-19 (2024)
Abstract Background Podocyte injury causes proteinuria and accelerates glomerular sclerosis during diabetic kidney disease (DKD). Disruptor of telomeric silencing 1-like (DOT1L), an evolutionarily conserved histone methyltransferase, has been reporte
Externí odkaz:
https://doaj.org/article/4565f6080f804790850958635920346d
Autor:
Yang Chen, Mingchao Zhang, Ruoyu Jia, Bin Qian, Chenyang Jing, Caihong Zeng, Dihan Zhu, Zhihong Liu, Ke Zen, Limin Li
Publikováno v:
Redox Biology, Vol 78, Iss , Pp 103439- (2024)
Podocyte injury is a critical event in the pathogenesis of diabetic nephropathy (DN). Hyperglycemia, oxidative stress, inflammation, and other factors contribute to podocyte damage in DN. In this study, we demonstrate that signaling regulatory protei
Externí odkaz:
https://doaj.org/article/9c5c3be4dd4845b185b78a472c2fe629
Publikováno v:
Renal Failure, Vol 46, Iss 2 (2024)
Minimal change disease (MCD) is a universal primary glomerular disease contributing to nephrotic syndrome. Lon peptidase 1 (LONP1) has been suggested to protect podocytes from damage during the progression of MCD. Accordingly, our research further ex
Externí odkaz:
https://doaj.org/article/d926e08bfae6461d84297891801d0c0f
Publikováno v:
Renal Failure, Vol 46, Iss 2 (2024)
Background Podocyte injury plays an important role in the occurrence and progression of diabetic kidney disease (DKD), which leads to albuminuria. Cytoskeletal remodeling is an early manifestation of podocyte injury in DKD. However, the underlying me
Externí odkaz:
https://doaj.org/article/b7622f6a02c54b64add13872901e6320
Publikováno v:
Renal Failure, Vol 46, Iss 1 (2024)
Diabetic kidney disease (DKD) is a common chronic microvascular complication of diabetes mellitus. Although studies have indicated the therapeutic potential of mesenchymal stem cells (MSCs) for DKD, the underlying molecular mechanisms remain unclear.
Externí odkaz:
https://doaj.org/article/8b496807dbb442fc9453ecd5d09a7e6c
Autor:
Yujiao Huang, Jie Geng, Mengdan Wang, Wenbin Liu, Haikun Hu, Wei Shi, Mei Li, Guiyang Huo, Guangrui Huang, Anlong Xu
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Podocytes are specialized terminally differentiated cells in the glomerulus that are the primary target cells in many glomerular diseases. However, the current podocyte cell lines suffer from prolonged in vitro differentiation and limited su
Externí odkaz:
https://doaj.org/article/c024ec4d06e343ed9bf13abf2a98bfcc
Autor:
Bangrui Huang, Rui Han, Hong Tan, Wenzhuo Zhu, Yang Li, Fakun Jiang, Chun Xie, Zundan Ren, Rou Shi
Publikováno v:
Natural Products and Bioprospecting, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Breviscapine, a natural flavonoid mixture derived from the traditional Chinese herb Erigeron breviscapus (Vant.) Hand-Mazz, has demonstrated a promising potential in improving diabetic nephropathy (DN). However, the specific active constitue
Externí odkaz:
https://doaj.org/article/79bc4a1b4efa4b05883696bbfa1809f6
Akademický článek
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Autor:
Zhaodi Han, Le Gong, Yani Xue, Rui Wang, Jing Liu, Xinyu Wang, Wenyan Zhao, Hui Liao, Rongshan Li
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
BackgroundPodocyte injury is a common pathologic mechanism in diabetic kidney disease (DKD) and obesity-related glomerulopathy (ORG). Our previous study confirmed that Inonotus obliquus (IO) improved podocyte injury on DKD rats. The current study exp
Externí odkaz:
https://doaj.org/article/47c292c827b14019bc578ee61f137aa9
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
IntroductionIncreasing evidence shows that hyperactive aryl hydrocarbon receptor (AHR) signalling is involved in renal disease. However, no currently available intervention strategy is effective in halting disease progression by targeting the AHR sig
Externí odkaz:
https://doaj.org/article/38d69408b9c9429dbae744a29076478e