Zobrazeno 1 - 10
of 820
pro vyhledávání: '"pleuromutilin"'
Publikováno v:
Antibiotics, Vol 13, Iss 11, p 1018 (2024)
In an effort to expand the spectrum of the antibacterial activity of pleuromutilin, a series of amine- and polyamine-linked analogues were prepared and evaluated for activities against a panel of microorganisms. Simple C-22-substituted amino esters o
Externí odkaz:
https://doaj.org/article/ec6ac71094104f4ea113dede3e50ace4
Akademický článek
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Publikováno v:
Microbiology Spectrum, Vol 12, Iss 2 (2024)
ABSTRACTAmphenmulin is a novel pleuromutilin derivative with great anti-mycoplasma potential. The present study evaluated the action characteristics of amphenmulin against Mycoplasma gallisepticum using pharmacokinetic/pharmacodynamic (PK/PD) modelin
Externí odkaz:
https://doaj.org/article/6582affc7f344afb82a2dba0483a496f
Autor:
Jie Ren, Qi-Wen Zhang, Xian-Jin He, Xiao-Ying Chen, Zi-Dan Zhou, Zhen-Ling Zeng, Zhen Jin, You-Zhi Tang
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
A series of pleuromutilin analogs containing substituted benzoxazole were designed, synthesised, and assessed for their antibacterial activity both in vivo and in vitro. The MIC of the synthesised derivatives was initially assessed using the broth di
Externí odkaz:
https://doaj.org/article/9d562e0180f543379eaa805f6e92a762
Autor:
Qi Wang, Jie Liu, Zi-Dan Zhou, Ke-Xin Zhou, Fei Li, Qi-Wen Zhang, Shou-Kai Wang, Wei Wang, Zhen Jin, You-Zhi Tang
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 2078-2091 (2022)
A series of pleuromutilin derivatives containing alkylamine and nitrogen heterocycle groups were designed and synthesised under mild conditions. The in vitro antibacterial activity of these semisynthetic derivatives against four strains of Staphyloco
Externí odkaz:
https://doaj.org/article/14538933bf36415fa90253b9bdb1bc2d
Publikováno v:
Journal of Education, Health and Sport, Vol 15, Iss 1 (2023)
Introduction and aim. Nowadays, the increasing resistance of bacteria is a concerning and challenging issue in terms of effective treatment of bacterial infections. The amount of available antibiotics has been quite constant for many years. The searc
Externí odkaz:
https://doaj.org/article/f7e93dc13adb4d65ac3b7cf19b14c075
Autor:
Kenneth Sue, Melissa M. Cadelis, Kerrin Hainsworth, Florent Rouvier, Marie-Lise Bourguet-Kondracki, Jean Michel Brunel, Brent R. Copp
Publikováno v:
Microorganisms, Vol 11, Iss 11, p 2791 (2023)
While pleuromutilin (1) and its clinically available derivatives (2–6) are highly effective against Gram-positive bacteria, they remain inactive against many pathogenic Gram-negative bacteria due to the efflux pump AcrAB-TolC. In an effort to broad
Externí odkaz:
https://doaj.org/article/a1b5db92c3ff47bcac0f1209821db7b9
Akademický článek
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Autor:
Logan M. Breiner, Anthony J. Briganti, Jennifer P. McCord, Moriah E. Heifetz, Sophia Y. Philbrook, Carla Slebodnick, Anne M. Brown, Andrew N. Lowell
Publikováno v:
Tetrahedron Chem, Vol 4, Iss , Pp 100034- (2022)
Pleuromutilin antimicrobials have given rise to the most recently FDA approved class of antibiotics for systemic human use. In this work, we describe a synthesis, assay, modeling approach to pleuromutilin development for the highly complex bacterial
Externí odkaz:
https://doaj.org/article/7651b2cc772c4e9b8b5387abcee697df