Zobrazeno 1 - 10
of 2 468
pro vyhledávání: '"platinum-resistance"'
Autor:
Marta Kluz-Barłowska, Tomasz Kluz, Wiesław Paja, Jaromir Sarzyński, Edyta Barnaś, Monika Łączyńska-Madera, Yaroslav Shpotyuk, Ewelina Gumbarewicz, Bartosz Klebowski, Jozef Cebulski, Joanna Depciuch
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract Patients with high-grade ovarian cancer have a poor prognosis, thus effective treatment remains an unmet medical issue of high importance. Moreover, finding the reason for resistance to cisplatin is a crucial task for the improvement of anti
Externí odkaz:
https://doaj.org/article/a7c0c38e13584e7e9aca13c9af25745b
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-13 (2024)
Abstract Ovarian cancer is a prevalent gynecologic malignancy with the second-highest mortality rate among gynecologic malignancies. Platinum-based chemotherapy is the first-line treatment for ovarian cancer; however, a majority of patients with ovar
Externí odkaz:
https://doaj.org/article/09ccba3ab5df4312bf4e8ca9a78b9b68
Publikováno v:
Zhongliu Fangzhi Yanjiu, Vol 51, Iss 10, Pp 813-819 (2024)
Ovarian cancer is a common gynecologic malignancy. In clinical practice, recurrent ovarian cancer is mainly classified into two categories on the basis of platinum-free interval, platinum-resistant and platinum-sensitive, corresponding to different t
Externí odkaz:
https://doaj.org/article/44bb69751be745c88ceb834bf20a0f19
Autor:
G. V. Zhukova, E. P. Ulyanova, A. P. Menshenina, T. I. Moiseenko, E. Yu. Zlatnik, E. M. Nepomnyashchaya, A. B. Sagakyants, E. V. Verenikina
Publikováno v:
Сибирский онкологический журнал, Vol 23, Iss 4, Pp 45-53 (2024)
The aim of the study was to evaluate a prognostic significance of immunohistochemical parameters in serous ovarian carcinomas and their statistical relationships after neoadjuvant treatment to assess the development of tumor resistance to platinum-co
Externí odkaz:
https://doaj.org/article/16577991c9404cefa3d2b666045ff7b7
Autor:
Franziska Maria Schwarz, Jan Dominik Kuhlmann, Jorrin Kämpfer, Anna Klimova, Daniel Martin Klotz, Lisa Freitag, Pia Herrmann, Viktoria Zinnow, Janice Smith, Theresia Scheller, Wolfgang Walther, Pauline Wimberger, Ulrike Stein
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-7 (2024)
Abstract The drug efflux transporter P-glycoprotein, encoded by the ABCB1 gene, promotes acquired chemoresistance. We explored the presence and clinical relevance of circulating cell-free ABCB1 transcripts (cfABCB1tx) in ovarian cancer patients (173
Externí odkaz:
https://doaj.org/article/bbbc1b0b2f144c9cb8c3f0c9409951ea
Autor:
Xingyu Jiang, Muwen Yang, Weijing Zhang, Dongni Shi, Yue Li, Lixin He, Shumei Huang, Boyu Chen, Xuwei Chen, Lingzhi Kong, Yibing Pan, Pinwei Deng, Rui Wang, Ying Ouyang, Xiangfu Chen, Jun Li, Zheng Li, Hequn Zou, Yanna Zhang, Libing Song
Publikováno v:
Advanced Science, Vol 11, Iss 47, Pp n/a-n/a (2024)
Abstract In epithelial ovarian cancer (EOC), platinum resistance, potentially mediated by cancer stem cells (CSCs), often leads to relapse and treatment failure. Here, the role of spindle pole body component 25 (SPC25) as a key determinant promoting
Externí odkaz:
https://doaj.org/article/1503d513de4c4be29beef0a3bde1ed9b
Autor:
Li-Rong Yang, Mei Yang, Liu-Lin Chen, Yong-Lin Shen, Yuan He, Zong-Ting Meng, Wan-Qi Wang, Feng Li, Zhi-Jin Liu, Lin-Hui Li, Yu-Feng Wang, Xin-Lei Luo
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
BackgroundMost epithelial ovarian cancer (EOC) eventually develops recurrence. Identification of high-risk patients can prompt earlier intervention and improve long-term outcomes. We used laboratory and clinical data to create models based on machine
Externí odkaz:
https://doaj.org/article/1d9b1ffe272f46e883305543194b5e35
Publikováno v:
Cancer Medicine, Vol 13, Iss 20, Pp n/a-n/a (2024)
ABSTRACT Background The purpose of this study is to construct models for predicting platinum resistance in high‐grade serous ovarian cancer (HGSOC) derived from quantitative spatial heterogeneity indicators obtained from 18F‐FDG PET/CT images. Me
Externí odkaz:
https://doaj.org/article/ca20c07eadcd43baab63f59e0d67fe57
Publikováno v:
World Journal of Surgical Oncology, Vol 22, Iss 1, Pp 1-13 (2024)
Abstract Background This study aimed to develop a novel nomogram that can accurately estimate platinum resistance to enhance precision medicine in epithelial ovarian cancer(EOC). Methods EOC patients who received primary therapy at the General Hospit
Externí odkaz:
https://doaj.org/article/6036ccd8171145509062d8e17c7979a9
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-23 (2024)
Abstract Background Ovarian cancer (OC) has the worst prognosis among gynecological malignancies, most of which are found to be in advanced stage. Cell reduction surgery based on platinum-based chemotherapy is the current standard of treatment for OC
Externí odkaz:
https://doaj.org/article/87141f573a6346e69243b366dd998c10