Diphenhydramine increases the therapeutic window for platinum drugs by simultaneously sensitizing tumor cells and protecting normal cells

Autor: Margarita Melnikova, Ulrike Sophie Wauer, Diana Mendus, Ralf Axel Hilger, Trudy G. Oliver, Kim Mercer, Björn Oliver Gohlke, Kati Erdmann, Dieter Niederacher, Hans Neubauer, Paul Buderath, Pauline Wimberger, Jan Dominik Kuhlmann, Jürgen Thomale

Publikováno v: Molecular Oncology, Vol 14, Iss 4, Pp 686-703 (2020)

Platinum‐based compounds remain a well‐established chemotherapy for cancer treatment despite their adverse effects which substantially restrict the therapeutic windows of the drugs. Both the cell type‐specific toxicity and the clinical responsi

Externí odkaz: https://doaj.org/article/c92a25a31abc4582925f02044ae84d0e

HSP90 Inhibition Synergizes with Cisplatin to Eliminate Basal-like Pancreatic Ductal Adenocarcinoma Cells

Autor: Katharina M. Ewers, Shilpa Patil, Waltraut Kopp, Jürgen Thomale, Tabea Quilitz, Anna Magerhans, Xin Wang, Elisabeth Hessmann, Matthias Dobbelstein

Publikováno v: Cancers
Cancers, Vol 13, Iss 6163, p 6163 (2021)
Cancers; Volume 13; Issue 24; Pages: 6163

Simple Summary Pancreatic cancer is currently difficult to treat, but the drug cisplatin represents one of the most important therapeutic options. We find that cells derived from this cancer fall into two classes regarding their sensitivity towards c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f43964505595ac5c5ed89935ac43eda
https://www.ncbi.nlm.nih.gov/pubmed/34944784

Coexisting Molecular Determinants of Acquired Oxaliplatin Resistance in Human Colorectal and Ovarian Cancer Cell Lines

Autor: Adrianus C. Laan, Godefridus J. Peters, Richard J. Honeywell, P. Noordhuis, Kasper van de Born

Publikováno v: International Journal of Molecular Sciences
Volume 20
Issue 15
International Journal of Molecular Sciences, 20(15). Multidisciplinary Digital Publishing Institute (MDPI)
International Journal of Molecular Sciences, Vol 20, Iss 15, p 3619 (2019)
Noordhuis, P, Laan, A C, van de Born, K, Honeywell, R J & Peters, G J 2019, ' Coexisting Molecular Determinants of Acquired Oxaliplatin Resistance in Human Colorectal and Ovarian Cancer Cell Lines ', International Journal of Molecular Sciences, vol. 20, no. 15 . https://doi.org/10.3390/ijms20153619

Oxaliplatin (OHP) treatment of colorectal cancer (CRC) frequently leads to resistance. OHP resistance was induced in CRC cell lines LoVo-92 and LoVo-Li and a platinum-sensitive ovarian cancer cell line, A2780, and related to cellular platinum accumul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e12b53cf78723e5991c6c4fddbd0fd9

Intra-hepatic arterial administration with miriplatin suspended in an oily lymphographic agent inhibits the growth of tumors implanted in rat livers by inducing platinum-DNA adducts to form and massive apoptosis

Autor: Fumio Nishikaku, Toshihiro Noguchi, Akemi Baba, Yasuyuki Tsutsumishita, Mitsuharu Hanada, Nobuyoshi Chiba, Takashi Yamaoka

Publikováno v: Cancer Chemotherapy and Pharmacology

Background Miriplatin (formerly SM-11355), a novel lipophilic platinum complex developed to treat hepatocellular carcinoma, is administered into the hepatic artery using an oily lymphographic agent (Lipiodol Ultra-Fluide®) as a carrier. We clarified

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c995d9a0b4aad19dfa5c32756b7b1f1
https://doi.org/10.1007/s00280-008-0895-3

Adaptive intrapatient dose escalation of cisplatin in combination with low-dose vp16 in patients with nonsmall cell lung cancer

Autor: N. van Zandwijk, M. J. van den Bent, Jaap Verweij, A.S.Th. Planting, M. de Boer-Dennert, A. van der Gaast, Jan H.M. Schellens, Marc Maliepaard, Elisabeth Brouwer, M.E.L. van der Burg, J. Ma

Publikováno v: British Journal of Cancer
British Journal of Cancer, 88, 814-821. Nature Publishing Group

The objective of this phase II and pharmacologic study was to explore the feasibility, toxicity and activity of adaptive intrapatient dose escalation of cisplatin in a dose-intensive weekly schedule using predefined levels of exposure, with the ultim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78d542e326d573ab138f25fa71a5de59
https://doi.org/10.1038/sj.bjc.6600794