Zobrazeno 1 - 10
of 16 770
pro vyhledávání: '"platelet derived growth factor receptor"'
Publikováno v:
International Journal of Ophthalmology, Vol 17, Iss 10, Pp 1800-1808 (2024)
AIM: To investigate the involvement of pericyte-Müller glia interaction in retinal damage repair and assess the influence of suppressing the platelet-derived growth factor receptor β (PDGFRβ) signaling pathway in retinal pericytes on photoreceptor
Externí odkaz:
https://doaj.org/article/40af24bfc22c4dc1bb30220590598704
Autor:
Insan Habib, Md Nayab Sulaimani, Deeba Shamim Jairajpuri, Afzal Hussain, Taj Mohammad, Mohamed F. Alajmi, Anas Shamsi, Md Imtaiyaz Hassan
Publikováno v:
Frontiers in Molecular Biosciences, Vol 11 (2024)
Platelet-derived growth factor receptor beta (PDGFRβ) belongs to the receptor tyrosine kinase (RTK) protein family and is implicated in several disorders such as hematopoietic, glial, and soft-tissue cancer, non-cancerous disorders, including skelet
Externí odkaz:
https://doaj.org/article/b799b44d73a54f1788582d211a38aaf9
Autor:
Natalie E. King, Jo-Maree Courtney, Lachlan S. Brown, Alastair J. Fortune, Nicholas B. Blackburn, Jessica L. Fletcher, Jake M. Cashion, Jana Talbot, Alice Pébay, Alex W. Hewitt, Gary P. Morris, Kaylene M. Young, Anthony L. Cook, Brad A. Sutherland
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Background Pericytes are multifunctional contractile cells that reside on capillaries. Pericytes are critical regulators of cerebral blood flow and blood–brain barrier function, and pericyte dysfunction may contribute to the pathophysiolog
Externí odkaz:
https://doaj.org/article/c8c8c85bb5db476ea1a3b1f8afc26262
Autor:
Mao YOKOTA, Koji OSUKA, Yusuke OHMICHI, Mika OHMICHI, Chiharu SUZUKI, Masahiro AOYAMA, Kenichiro IWAMI, Satoru HONMA, Shigeru MIYACHI
Publikováno v:
Neurologia Medico-Chirurgica, Vol 64, Iss 1, Pp 50-55 (2024)
Angiogenesis is one of the growth mechanisms of chronic subdural hematoma (CSDH). Pericytes have been implicated in the capillary sprouting during angiogenesis and are involved in brain ischemia and diabetic retinopathy. This study examined the peric
Externí odkaz:
https://doaj.org/article/2c9ace7555854aa2b733c146cf37bde1
Autor:
Mariagiovanna Russo, Amina Zahaf, Abdelmoumen Kassoussi, Ariane Sharif, Hélène Faure, Elisabeth Traiffort, Martial Ruat
Publikováno v:
Cells, Vol 13, Iss 21, p 1808 (2024)
Failure of myelin regeneration by oligodendrocytes contributes to progressive decline in many neurological diseases. Here, using in vitro and in vivo rodent models, functional blockade, and mouse brain demyelination, we demonstrate that Sonic hedgeho
Externí odkaz:
https://doaj.org/article/ae38fecd7da84749adef8bb4063a6a48
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
Receptor tyrosine kinases (RTKs) mediate the actions of growth factors in metazoans. In decapod crustaceans, RTKs are implicated in various physiological processes, such molting and growth, limb regeneration, reproduction and sexual differentiation,
Externí odkaz:
https://doaj.org/article/4ed12252abb54525812c57f25a6c0fda
Publikováno v:
Zhongliu Fangzhi Yanjiu, Vol 50, Iss 9, Pp 854-859 (2023)
Objective To investigate the effect of imatinib on the growth of A549 non-small cell lung cancer transplanted tumors and the expression of PDGFB and PDGFRβ proteins in tumor tissues and stroma in nude mice and to explore the underlying tumor suppres
Externí odkaz:
https://doaj.org/article/f0232a02228b44b581a26c0e9ed62bd2
Autor:
Olivia Wegrzyniak, Bo Zhang, Johanna Rokka, Maria Rosestedt, Bogdan Mitran, Pierre Cheung, Emmi Puuvuori, Sofie Ingvast, Jonas Persson, Helena Nordström, John Löfblom, Fredrik Pontén, Fredrik Y. Frejd, Olle Korsgren, Jonas Eriksson, Olof Eriksson
Publikováno v:
EJNMMI Radiopharmacy and Chemistry, Vol 8, Iss 1, Pp 1-18 (2023)
Abstract Background Platelet-derived growth factor receptor beta (PDGFRβ) is a receptor overexpressed on activated hepatic stellate cells (aHSCs). Positron emission tomography (PET) imaging of PDGFRβ could potentially allow the quantification of fi
Externí odkaz:
https://doaj.org/article/84daea9b1f234c4eacb9912e8eedc172
Autor:
Su Ir Lyu, Jannik Johannsen, Adrian Georg Simon, Karl Knipper, Nora Wuerdemann, Shachi Jenny Sharma, Martin Thelen, Kevin Karl Hansen, Caroline Fretter, Charlotte Klasen, Julia Esser, Malte Christian Suchan, Helen Abing, Philipp Heinrich Zimmermann, Anne Maria Schultheis, Hans Anton Schloesser, Jens Peter Klussmann, Alexander Quaas, Hans Nikolaus Caspar Eckel
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
Background: The incidence of oropharyngeal squamous cell carcinoma (OPSCC) is rapidly increasing in high income countries due to its association with persistent high-risk human papilloma virus (HPV) infection. Recent scientific advances have highligh
Externí odkaz:
https://doaj.org/article/9d95e0c057d14226bebce5b3318bd141
Autor:
Md Rashedunnabi Akanda, Eun-Jung Ahn, Yeong Jin Kim, S M Abdus Salam, Myung-Giun Noh, Tae-Kyu Lee, Sung Sun Kim, Kyung-Hwa Lee, Kyung-Sub Moon
Publikováno v:
BMC Cancer, Vol 23, Iss 1, Pp 1-12 (2023)
Abstract Background Breast cancer brain metastasis (BCBM) is a growing therapeutic challenge and clinical concern. Stromal cancer-associated fibroblasts (CAFs) are crucial factors in the modulation of tumorigeneses and metastases. Herein, we investig
Externí odkaz:
https://doaj.org/article/cd731f35159245e59bf32f6c51058b48