Zobrazeno 1 - 10
of 15 431
pro vyhledávání: '"plasmid DNA."'
Autor:
Bostjan Markelc, Tanja Jesenko, Simona Kranjc Brezar, Masa Omerzel, Ursa Lampreht Tratar, Andrej Rencelj, Urska Matkovic, Katarina Znidar, Spela Kos, Kristina Levpuscek, Ziva Pisljar, Ursa Kesar, Tilen Komel, Tim Bozic, Aneja Tuljak, Rosana Hudej, Matjaz Peterka, Urska Kamensek, Andrej Cör, Gorana Gasljevic, Alenka Nemec Svete, Natasa Tozon, Gregor Sersa, Maja Cemazar
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Immunotherapeutic drugs are promising medicines for cancer treatment. A potential candidate for immunotherapy is interleukin-12 (IL-12), a cytokine well known for its ability to mediate antitumor activity. We developed a plasmid encoding hum
Externí odkaz:
https://doaj.org/article/31c16b9fe1ca4c038f2fb6e10cd7146e
Publikováno v:
Journal of Biological Engineering, Vol 18, Iss 1, Pp 1-13 (2024)
Abstract Background Recent therapeutic-plasmid DNA vaccine strategies for rheumatoid arthritis (RA) have significantly improved. Our pcDNA-CCOL2A1 vaccine is the most prominent and the first antigen-specific tolerising DNA vaccine with potent therape
Externí odkaz:
https://doaj.org/article/ce7dc5a95f1e42f6ad7644be745e805b
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 2, Pp 102210- (2024)
Elevated brain angiotensin II activity plays a key role in the development of neurogenic hypertension. While blood pressure (BP) control in neurogenic hypertension has been successfully demonstrated by regulating central angiotensin II activity, curr
Externí odkaz:
https://doaj.org/article/615f208c69c645fc8f101cc58f4bc35b
Autor:
Xijun Piao, Yujie Tang, Xiuzhi Li, Weicheng Zhang, Wei Yang, Xining Xu, Wenjing Wang, Jiajia Jiang, Jun Xu, Kunkun Hu, Meiling Xu, Mengjie Liu, Mengfei Sun, Lin Jin
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 2, Pp 102223- (2024)
The development of messenger RNA (mRNA) vaccines and therapeutics necessitates the production of high-quality in vitro-transcribed mRNA drug substance with specific critical quality attributes (CQAs), which are closely tied to the uniformity of linea
Externí odkaz:
https://doaj.org/article/74cf14984576444d940d2df9cabcc378
Autor:
Amanda Sales Conniff, Aneeshea Cason, Juliana Gonzalez Alvarado, Manya Bhandary, Shreena Patel, Julie Singh, Richard Heller, Loree C. Heller
Publikováno v:
Re:GEN Open, Vol 4, Iss 1, Pp 1-8 (2024)
Background: Models of muscle cell culture allow simple manipulation to optimize gene transfer experiments, offering a significant opportunity to model muscle effects by allowing precise control of the cell culture environment in a cost-effective mann
Externí odkaz:
https://doaj.org/article/e2e1260046754ded9ad3ab39116d0be1
Autor:
D. S. O. Daian e Silva, L. J. Cox, A. S. Rocha, Á. Lopes-Ribeiro, J. P. C. Souza, G. M. Franco, J. L. C. Prado, T. A. Pereira-Santos, M. L. Martins, J. G. A. Coelho-dos-Reis, T. M. Gomes-de-Pinho, F. G. Da Fonseca, E. F. Barbosa-Stancioli
Publikováno v:
Virology Journal, Vol 20, Iss 1, Pp 1-15 (2023)
Abstract Background Human T-lymphotropic virus 1 (HTLV-1) is associated with the development of several pathologies and chronic infection in humans. The inefficiency of the available treatments and the challenge in developing a protective vaccine hig
Externí odkaz:
https://doaj.org/article/4c9029ca13934f2e8a681c29bdbc647b
Autor:
A Šećerović, B Markelc, I Matić, A Frischer, A Hacobian, T Jesenko, M Cemazar, H Redl, D Marolt Presen, A Ivković
Publikováno v:
European Cells & Materials, Vol 46, Pp 138-153 (2023)
Muscle tissues attached to the proximal ends of hamstring tendon grafts are routinely discarded during anterior cruciate ligament (ACL) reconstruction. Preserving the muscle on the ACL graft was shown to improve the surgery outcomes, possibly due to
Externí odkaz:
https://doaj.org/article/7bf02af7b8bc4ec1ad45ab21882cff2e
Autor:
Yizong Hu, Brendan A. Eder, Jinghan Lin, Sixuan Li, Yining Zhu, Tza-Huei Wang, Ting Guo, Hai-Quan Mao
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 1, Pp 101194- (2024)
The transfection efficiency and stability of the delivery vehicles of plasmid DNA (pDNA) are critical metrics to ensure high-quality and high-yield production of viral vectors. We previously identified that the optimal size of pDNA/poly(ethylenimine)
Externí odkaz:
https://doaj.org/article/15de10c460aa4bb3a0fa8b2a57e0f9f7
Akademický článek
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Autor:
Aleksandra Radko, Sebastian Lalik, Natalia Górska, Aleksandra Deptuch, Jolanta Świergiel, Monika Marzec
Publikováno v:
Materials, Vol 17, Iss 14, p 3530 (2024)
Currently, new functional materials are being created with a strong emphasis on their ecological aspect. Materials and devices based on DNA biopolymers, being environmentally friendly, are therefore very interesting from the point of view of applicat
Externí odkaz:
https://doaj.org/article/c3e96494a90c4c1ca07e596cc564dc30