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of 52 381
pro vyhledávání: '"plasma protein binding"'
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The plasma protein binding (PPB) of a drug plays a key role in both its pharmacokinetic and pharmacodynamic properties. During lead optimisation, medium and high throughput methods for the early determination of PPB can provide important inf
The plasma protein binding (PPB) of a drug plays a key role in both its pharmacokinetic and pharmacodynamic properties. During lead optimisation, medium and high throughput methods for the early determination of PPB can provide important inf
Externí odkaz:
http://hdl.handle.net/10454/19948
Autor:
Mariana Babayeva, Iva Srdanovic
Publikováno v:
Journal of Cannabis Research, Vol 6, Iss 1, Pp 1-5 (2024)
Abstract Background Cannabidiol is highly bound to plasma proteins. Changes in its protein binding can lead to altered unbound plasma concentrations and result in alteration of pharmacological activity of cannabidiol-containing medications. This rese
Externí odkaz:
https://doaj.org/article/31b0532ab8f743ad9afe76685ed7e39a
Publikováno v:
Veterinary Medicine and Science, Vol 10, Iss 4, Pp n/a-n/a (2024)
Abstract Background Although research on the mechanism and control of pain and inflammation in fish has increased in recent years, the use of analgesic drugs is limited due to the lack of pharmacological information about analgesic drugs. Tolfenamic
Externí odkaz:
https://doaj.org/article/f1c4f21fb9ff4cfbb772129915126d81
Autor:
Fengjie Liu, Yuanyuan Huang, Xiujuan Lin, Qianwen Li, Idoia Gallego, Guoqiang Hua, Nadia Benkirane-Jessel, José Luis Pedraz, Panpan Wang, Murugan Ramalingam, Yu Cai
Publikováno v:
Arabian Journal of Chemistry, Vol 17, Iss 10, Pp 105947- (2024)
Triple-negative breast cancer (TNBC) is the most malignant subtype of breast cancer (BC) with a poor prognosis. Currently, chemotherapy and neoadjuvant chemotherapy continue to have limited efficacy in TNBC. With the deepening of research, nano targe
Externí odkaz:
https://doaj.org/article/db1cfe24376f4c66b181e1febacdd6ee
Autor:
Christian Vaccarin, Ana Katrina Mapanao, Luisa M. Deberle, Anna E. Becker, Francesca Borgna, Giovanni Marzaro, Roger Schibli, Cristina Müller
Publikováno v:
Cancers, Vol 16, Iss 7, p 1262 (2024)
Transthyretin binders have previously been used to improve the pharmacokinetic properties of small-molecule drug conjugates and could, thus, be utilized for radiopharmaceuticals as an alternative to the widely explored “albumin binder concept”. I
Externí odkaz:
https://doaj.org/article/82b9b6b5f2b14d19b577b25b9afd33e6
Publikováno v:
Pharmaceutics, Vol 16, Iss 2, p 230 (2024)
Human serum alpha-1-acid glycoprotein (AAG) is an acute-phase plasma protein involved in the binding and transport of many drugs, especially basic and lipophilic substances. The sialic acid groups that terminate the N-glycan chains of AAG have been r
Externí odkaz:
https://doaj.org/article/73f5205c75bb42b69dae01046d8659b0
Autor:
Aero Renyer, Krishna Ravindra, Barbara A. Wetmore, Jermaine L. Ford, Michael DeVito, Michael F. Hughes, Leah C. Wehmas, Denise K. MacMillan
Publikováno v:
Toxics, Vol 11, Iss 12, p 951 (2023)
Few studies are available on the environmental and toxicological effects of perfluoroalkyl ether carboxylic acids (PFECAs), such as GenX, which are replacing legacy PFAS in manufacturing processes. To collect initial data on the toxicity and toxicoki
Externí odkaz:
https://doaj.org/article/f755faf0b693462dbddd645d9ae1fec7
Publikováno v:
Molecules, Vol 28, Iss 20, p 7107 (2023)
Chromatographic methods, apart from in silico ones, are commonly used rapid techniques for the evaluation of certain properties of biologically active compounds used for their prediction of pharmacokinetic processes. Thiosemicarbazides are compounds
Externí odkaz:
https://doaj.org/article/adc2f54f92a848a9b62ef4b9ef35cc76
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