Prevalence of pks genotoxin among hospital-acquired Klebsiella pneumoniae

Autor: Amira H. El-Ashry, Shimaa R. Hendawy, Noha Mostafa Mahmoud

Publikováno v: AIMS Microbiology, Vol 8, Iss 1, Pp 73-82 (2022)

The pks genotoxic K. pneumoniae has recently triggered a widespread alarm. DNA damage and higher virulence have been linked to colibactin, a genotoxin expressed by the pks genomic island. Little is known about its molecular epidemiology in clinical i

Externí odkaz: https://doaj.org/article/99558914aa724e449b3fad2949375763

The Escherichia coli colibactin resistance protein ClbS is a novel DNA binding protein that protects DNA from nucleolytic degradation

Autor: Darja Žgur Bertok, Matej Butala, Zdravko Podlesek, Eric Oswald, Katja Molan, Vesna Hodnik

Publikováno v: DNA Repair
DNA Repair, Elsevier, 2019, 79, pp.50-54. ⟨10.1016/j.dnarep.2019.05.003⟩
DNA Repair (79), 50-54. (2019)
DNA Repair, vol. 79, pp. 50-54, 2019.
DNA Repair, 2019, 79, pp.50-54. ⟨10.1016/j.dnarep.2019.05.003⟩

International audience; Cells employ specific and nonspecific mechanisms to protect their genome integrity against exogenous and endogenous factors. The clbS gene is part of the polyketide synthase machinery (pks genomic island) encoding colibactin,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13b56b474960dc637372749204d20f91
https://pubmed.ncbi.nlm.nih.gov/31129429