Zobrazeno 1 - 10
of 3 446
pro vyhledávání: '"pilot trial"'
Publikováno v:
BMC Medical Research Methodology, Vol 24, Iss 1, Pp 1-12 (2024)
Abstract Background Whether or not to progress from a pilot study to a definitive trial is often guided by pre-specified quantitative progression criteria with three possible outcomes. Although the choice of these progression criteria will help to de
Externí odkaz:
https://doaj.org/article/c689bf186d7144a1baf80fc92a99fcd8
Autor:
Natalie Kreitzer, Stephanie Fink, Opeolu Adeoye, Brad Kurowski G, Shari Wade, Heidi Sucharew, Tamilyn Bakas
Publikováno v:
Contemporary Clinical Trials Communications, Vol 41, Iss , Pp 101356- (2024)
Introduction: After injury, survivors of moderate to severe traumatic brain injury (msTBI) depend on informal family caregivers. Upwards of 77 % of family caregivers experience poor outcomes, such as adverse life changes, poor health-related quality
Externí odkaz:
https://doaj.org/article/336af7b9143d434bad24b07e08f22c82
Publikováno v:
Journal of Pain Research, Vol Volume 17, Pp 837-849 (2024)
Yoona Oh,1,2,* Chang-Hyun Han,3,4,* Yeonhak Kim,1 Jihun Kim,1 Changsop Yang,3 Young Eun Choi,5 Byoung-Kab Kang,3 Kun Hyung Kim,1,2 Gi Young Yang,1,2 Byung Ryul Lee,1,2 Eunseok Kim1,2 1Department of Acupuncture and Moxibustion Medicine, Pusan
Externí odkaz:
https://doaj.org/article/b2c0d349c9454be091e72da600bd596e
Autor:
Rachel Adams, Rachel E Jordan, Alisha Maher, Peymane Adab, Timothy Barrett, Sheriden Bevan, Lucy Cooper, Ingrid DuRand, Florence Edwards, Pollyanna Hardy, Ciara Harris, Nicola R Heneghan, Kate Jolly, Sue Jowett, Tom Marshall, Margaret O’Hara, Christopher Poyner, Kiran Rai, Hugh Rickards, Ruth Riley, Natalie Ives, Steven Sadhra, Sarah Tearne, Gareth Walters, Elizabeth Sapey
Publikováno v:
Health and Social Care Delivery Research, Vol 12, Iss 23 (2024)
Background Staff sickness absenteeism and presenteeism (attending work while unwell) incur high costs to the NHS, are associated with adverse patient outcomes and have been exacerbated by the COVID-19 pandemic. The main causes are mental and musculos
Externí odkaz:
https://doaj.org/article/f8b4cdfd2dd54f8c94e748bc276b026d
Autor:
Xiaoyan Zheng, Ran Ji, Chaoliang Li, Hao Zhu, Ziyi Jiang, Jingwen Zhang, Yang Su, Siyi Yu, Zheng Yu, Xingyu Lv, Fanrong Liang, Jie Yang
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
IntroductionIn vitro fertilization (IVF) is a technology that assists couples experiencing infertility to conceive children. However, unsuccessful attempts can lead to significant physical and financial strain. Some individuals opt for electro-acupun
Externí odkaz:
https://doaj.org/article/6b86269d840c46c38a672da619fe8eb2
Autor:
Matthew K. Taylor, Jeffrey M. Burns, In-Young Choi, Trent J. Herda, Phil Lee, Aaron N. Smith, Debra K. Sullivan, Russell H. Swerdlow, Heather M. Wilkins
Publikováno v:
Pilot and Feasibility Studies, Vol 10, Iss 1, Pp 1-10 (2024)
Abstract Background Impaired brain bioenergetics is a pathological hallmark of Alzheimer’s disease (AD) and is a compelling target for AD treatment. Patients with AD exhibit dysfunction in the brain creatine (Cr) system, which is integral in mainta
Externí odkaz:
https://doaj.org/article/69cb69366c884bc0acef5ad16e3c9069
Autor:
Carmela Cosola, Francesco Pesce, Maria De Angelis, Valentina Maranzano, Annapaola Zito, Eustacchio Montemurno, Giuseppe Dalfino, Saverio Loiudice, Vincenzo Creanza, Giovanni Pompa, Marco Matteo Ciccone, Giuseppe Grandaliano, Giovanni Stallone, Loreto Gesualdo
Publikováno v:
BMC Nutrition, Vol 10, Iss 1, Pp 1-10 (2024)
Abstract High salt intake and compliance to low-sodium (LS) diets are critical in hypertension. Salt reduction in processed foods can help to achieve the target sodium intake. To verify the hypothesis that an innovative LS formulation of a traditiona
Externí odkaz:
https://doaj.org/article/c35cae027505404ab574fff69febb9ff
Autor:
Da Zhao, Zhengguo Li, Xinli Hou, Lei Yang, Zeng Li, Li Yan, Hongling Li, Hua Liu, Xiaoping Liu, Feixue Song, Guixiang Li, Yu Zhang, Xiaoming Hou
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
BackgroundBased on pharmacoeconomics, drug availability and actual treatment, optimal treatment regimens for Chinese non-small-cell lung carcinoma (NSCLC) patients over 70 years old are needed.MethodsThis multicenter, single-arm pilot trial enrolled
Externí odkaz:
https://doaj.org/article/d59dd34bbefb4c36917d3dfcff8e1fa6
Publikováno v:
Pilot and Feasibility Studies, Vol 9, Iss 1, Pp 1-15 (2023)
Abstract Background Stress levels and thus the risk of developing related physical and mental health conditions are rising worldwide. Dysfunctional beliefs contribute to the development of stress. Potentially, such beliefs can be modified with approa
Externí odkaz:
https://doaj.org/article/563089c945d240178f221a93db696777
Autor:
Lawrence Mbuagbaw, Lucy Huizhu Chen, Eunice Aluko, Maya Stevens-Uninsky, Akudo C. J. Eze-Onuorah, Michael Cristian Garcia, Larysa Stech, Tariq Atkin-Jones, Nadia Rehman, Amidu Raifu
Publikováno v:
Pilot and Feasibility Studies, Vol 9, Iss 1, Pp 1-9 (2023)
Abstract Introduction Pilot and feasibility trials use predetermined thresholds for feasibility outcomes to decide if a larger trial is feasible. These thresholds may be derived from the literature, observational data, or clinical experience. The aim
Externí odkaz:
https://doaj.org/article/efe1c525f918449fb4efcd8ec22d2696