Zobrazeno 1 - 10
of 2 626
pro vyhledávání: '"piezo1"'
Publikováno v:
口腔疾病防治, Vol 32, Iss 10, Pp 756-764 (2024)
Objective To investigate the effect of the Piezo1 channel on tension-side angiogenesis and osteogenic remodeling during orthodontic tooth movement, so as to provide an experimental basis for accelerating orthodontic periodontal tissue remodeling. Met
Externí odkaz:
https://doaj.org/article/f1ff334f34c84fe38e3389fe0719498a
Autor:
Fan Chen, Zian Zhang, Wenzhe Wang, Chang Liu, Zhenchao Huang, Chaoqun Yu, Zhen Jia, Haining Zhang
Publikováno v:
Journal of Orthopaedic Surgery and Research, Vol 19, Iss 1, Pp 1-10 (2024)
Abstract Acute cartilage injuries, such as intra-articular fractures and blunt impacts, frequently result in chondrocyte death and extracellular matrix (ECM) degradation, significantly elevating the risk of post-traumatic osteoarthritis (PTOA). Despi
Externí odkaz:
https://doaj.org/article/d57e539be70143feb3e72b23ad2d84ab
Autor:
Lingwei Huang, Yiren Jiao, Hangbin Xia, Huili Li, Jing Yu, Yumei Que, Zhen Zeng, Chen Fan, Chen Wang, Chen Yang, Jiang Chang
Publikováno v:
Journal of Orthopaedic Translation, Vol 48, Iss , Pp 146-155 (2024)
Background: Long-term physical inactivity probably leads to a co-existence of osteoporosis and sarcopenia which result in a high risk of falls, fractures, disability and even mortality. However, universally applicable and feasible approaches are lack
Externí odkaz:
https://doaj.org/article/d9f2a39fc7ee472197bf1b9896b057d6
Autor:
Hang Zhou, Hongzhi Liu, Minmin Lin, Hantang Wang, Jingjing Zhou, Ming Li, Xue Yang, Guibing Fu, Chao Liu
Publikováno v:
Journal of Orthopaedic Translation, Vol 48, Iss , Pp 11-24 (2024)
Background: Hyperbaric oxygen (HBO) therapy is widely used to treat bone defects, but the correlation of high oxygen concentration and pressure to osteogenesis is unclear. Methods: Bilateral monocortical tibial defect surgeries were performed on 12-w
Externí odkaz:
https://doaj.org/article/f7c275409e26465face294c4e55a1b6a
Autor:
Tian Tao, Qing Shu, Yawen Zhao, Wenying Guo, Jinting Wang, Yuhao Shi, Shiqi Jia, Hening Zhai, Hui Chen, Cunchuan Wang, Geyang Xu
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 8, Pp 3576-3590 (2024)
Obesity is primarily caused by excessive intake as well as absorption of sugar and lipid. Postprandial surge in distention pressure and intestinal motility accelerates the absorption of nutrients. The response of intestinal epithelial cells to mechan
Externí odkaz:
https://doaj.org/article/b133bb2abeb04a6f995b01f5fc13500b
Autor:
Donghao Gan, Chu Tao, Xiaowan Jin, Xiaohao Wu, Qinnan Yan, Yiming Zhong, Qingyun Jia, Lisheng Wu, Shaochuan Huo, Lei Qin, Guozhi Xiao
Publikováno v:
Journal of Advanced Research, Vol 62, Iss , Pp 105-117 (2024)
Introduction: Osteoarthritis (OA) is a devastating whole-joint disease affecting a large population worldwide with no cure; its mechanism remains poorly defined. Abnormal mechanical stress is the main pathological factor of OA. Objectives: To investi
Externí odkaz:
https://doaj.org/article/1d95a3e907bf4573b6f90f2aa37d980d
Autor:
Tejaswini Tadge, Ashwini Pattewar, Namdev More, Srivalliputtur Sarath Babu, Ravichandiran Velyutham, Govinda Kapusetti
Publikováno v:
Engineered Regeneration, Vol 5, Iss 2, Pp 170-185 (2024)
Almost every life form, from the tiniest bacterium to humans, is mechanosensitive, implying it can use mechanical stresses to trigger certain physiological responses in the form of electric signals. Mechanotransduction largely relies on ion channels
Externí odkaz:
https://doaj.org/article/d01be33fe36c4c889c1d8fbfcd209feb
Autor:
Minghai Ma, Xing Li, Minxuan Jing, Pu Zhang, Mengzhao Zhang, Lu Wang, Xiao Liang, Yunzhong Jiang, Jianpeng Li, Jiale He, Xinyang Wang, Min Lin, Lei Wang, Jinhai Fan
Publikováno v:
Advanced Science, Vol 11, Iss 42, Pp n/a-n/a (2024)
Abstract Peptide‐based drugs hold great potential for cancer treatment, and their effectiveness is driven by mechanisms on how peptides target cancer cells and escape from potential lysosomal entrapment post‐endocytosis. Yet, the mechanisms remai
Externí odkaz:
https://doaj.org/article/80b78c2de9a74d64abfba314b1804d43
Autor:
Yanling Huang, Haocong Mo, Jie Yang, Luyang Gao, Tian Tao, Qing Shu, Wenying Guo, Yawen Zhao, Jingya Lyu, Qimeng Wang, Jinghui Guo, Hening Zhai, Linyan Zhu, Hui Chen, Geyang Xu
Publikováno v:
eLife, Vol 13 (2024)
Glucagon-like peptide 1 (GLP-1) is a gut-derived hormone secreted by intestinal L cells and vital for postprandial glycemic control. As open-type enteroendocrine cells, whether L cells can sense mechanical stimuli caused by chyme and thus regulate GL
Externí odkaz:
https://doaj.org/article/eb257dc2f9fd413daa5bdd3902f61cde
Autor:
Yining Lan, Jing Lu, Shaohan Zhang, Chunxiao Jie, Chunyong Chen, Chao Xiao, Chao Qin, Daobin Cheng
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 21 (2024)
Background Disturbed flow generates oscillatory shear stress (OSS), which in turn leads to endothelial inflammation and atherosclerosis. Piezo1, a biomechanical force sensor, plays a crucial role in the cardiovascular system. However, the specific ro
Externí odkaz:
https://doaj.org/article/397b6a4b1a1b4bf987908c00bca2543c