Zobrazeno 1 - 10
of 13
pro vyhledávání: '"physiopathology [Subthalamic Nucleus]"'
Autor:
Roxanne Lofredi, Wolf-Julian Neumann, Friederike Irmen, Johanna Nieweler, Gerd-Helge Schneider, Georg Cem Auernig, Andrea A. Kühn, Andreas Horn
Publikováno v:
Brain 144(1), 44-52 (2021). doi:10.1093/brain/awaa341
The subthalamic nucleus is part of a global stopping network that also includes the presupplementary motor area and inferior frontal gyrus of the right hemisphere. In Parkinson’s disease, subthalamic deep brain stimulation improves movement initiat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36ccbda96901ac1cf13609fa85400e30
https://pub.dzne.de/record/155618
https://pub.dzne.de/record/155618
Publikováno v:
PLoS ONE
PLOS ONE 15(12), e0244148 (2020). doi:10.1371/journal.pone.0244148
PLoS ONE, Vol 15, Iss 12, p e0244148 (2020)
PLOS ONE 15(12), e0244148 (2020). doi:10.1371/journal.pone.0244148
PLoS ONE, Vol 15, Iss 12, p e0244148 (2020)
BackgroundIn addition to the typical motor symptoms, a majority of patients suffering from Parkinson's disease experience language impairments. Deep Brain Stimulation of the subthalamic nucleus robustly reduces motor dysfunction, but its impact on la
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b23a47d097eb4962be980fdabdac3adf
http://europepmc.org/articles/PMC7771859
http://europepmc.org/articles/PMC7771859
Autor:
Andreas Kupsch, Jens K. Haumesser, Christoph van Riesen, Daniel Harnack, Johanna Kühn, Vadim V. Nikulin, Andrea A. Kühn, Franziska Pellegrini, Maximilian H. Beck, Wolf-Julian Neumann, Jennifer Altschüler
Publikováno v:
Experimental neurology 335, 113513-(2021). doi:10.1016/j.expneurol.2020.113513
Excessive beta activity has been shown in local field potential recordings from the cortico-basal ganglia loop of Parkinson's disease patients and in its various animal models. Recent evidence suggests that enhanced beta oscillations may play a centr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7340cb26c8aa8437995360b312375aeb
https://pubmed.ncbi.nlm.nih.gov/33148526
https://pubmed.ncbi.nlm.nih.gov/33148526
Autor:
Christian Schlenstedt, Martina Mancini, Idil Cebi, Alireza Gharabaghi, Daniel Weiss, Monika Pötter-Nerger, Anna Schöllmann, Melanie Heilbronn, Marlieke Scholten
Publikováno v:
Parkinsonism & related disorders 66, 34-39 (2019). doi:10.1016/j.parkreldis.2019.06.023
Background A precise understanding of the neuronal circuits involved in the control of anticipatory postural adjustments (APAs) for gait initiation is missing. Neurostimulation in Parkinson's disease (PD) provides a method of modulating APAs to gain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92072ca446e4d82d0bfa79b27160c4cc
https://pubmed.ncbi.nlm.nih.gov/31272926
https://pubmed.ncbi.nlm.nih.gov/31272926
Autor:
Limin Sun, Hermann Hinrichs
Publikováno v:
Journal of neuroscience methods 266, 126-136 (2016). doi:10.1016/j.jneumeth.2016.03.020
Background Deep brain stimulation (DBS) is a well established therapy to treat movement disorders such as Parkinson's disease. More recently it has also been discussed as a therapy for certain psychiatric diseases. However, during active DBS the reco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c595bed90ae3a51326b3a8eb1d9c9a6f
https://doi.org/10.1016/j.jneumeth.2016.03.020
https://doi.org/10.1016/j.jneumeth.2016.03.020
Autor:
Hartwig R. Siebner, Philip Plettig, Friederike Irmen, Gerd-Helge Schneider, Wolf-Julian Neumann, Andreas Horn, David Meder, Andrea A. Kühn
Publikováno v:
Movement disorders 34(3), 366-376 (2018). doi:10.1002/mds.27576
Background STN-DBS effectively treats motor symptoms of advanced PD. Nonmotor cognitive symptoms, such as impaired impulse control or decision making, may either improve or worsen with DBS. A potential mediating factor of DBS-induced modulation of co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::831b1f3afd31059eefeeba6548b6a259
https://pub.dzne.de/record/140585
https://pub.dzne.de/record/140585
Autor:
Andreas Horn, Ana Luisa de Almeida Marcelino, Siobhan Ewert, Patricia Krause, Henning Schroll, Wolf-Julian Neumann, Gerd-Helge Schneider, Friederike Irmen, Andrea A. Kühn, Fred H. Hamker
Publikováno v:
Brain 141(9), 2655 – 2669 (2018). doi:10.1093/brain/awy206
Dopamine exerts modulatory signals on cortex-basal ganglia circuits to enable flexible motor control. Parkinson's disease is characterized by a loss of dopaminergic innervation in the basal ganglia leading to complex motor and non-motor symptoms. Cli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3124667f6a96b4583a3e61e0cf5368c4
https://doi.org/10.1093/brain/awy206
https://doi.org/10.1093/brain/awy206
Publikováno v:
Movement disorders 31(11), 1748-1751 (2016). doi:10.1002/mds.26759
Beta band oscillations in the subthalamic nucleus (STN) have been proposed as a pathophysiological signature in patients with Parkinson's disease (PD). The aim of this study was to investigate the potential association between oscillatory activity in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::86edaefab5978d53090f75d52680c277
https://europepmc.org/articles/PMC5120686/
https://europepmc.org/articles/PMC5120686/
Autor:
Andrea A. Kühn, María Herrojo Ruiz, Ettore A. Accolla, Gerd-Helge Schneider, Tanja Schmitz-Hübsch, Andreas Horn, Bogdan Draganski
Publikováno v:
Brain 139(9), 2503-2515 (2016). doi:10.1093/brain/aww182
Brain
Brain
Deep brain stimulation of the subthalamic nucleus is an established treatment for the motor symptoms of Parkinson’s disease. Given the frequent occurrence of stimulation- induced affective and cognitive adverse effects, a better understanding about
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d540146fc03a3cab2e30def72d04041
https://pub.dzne.de/record/138781
https://pub.dzne.de/record/138781
Autor:
Weiss, Daniel, Breit, Sorin, Hoppe, Julia, Hauser, Ann-Kathrin, Freudenstein, Dirk, Krüger, Rejko, Sauseng, Paul, Govindan, Rathinaswamy B, Gerloff, Christian
Publikováno v:
European journal of neuroscience 35(6), 896-908 (2012). doi:10.1111/j.1460-9568.2012.08014.x
Pathological synchronization in large-scale motor networks constitutes a pathophysiological hallmark of Parkinson's disease (PD). Corticomuscular synchronization in PD is pronounced in lower frequency bands (10 Hz), whereas efficient cortical motor i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::cc20ffc17fa4f0eabfd9dd614c6e5dc5
https://pubmed.ncbi.nlm.nih.gov/22393899
https://pubmed.ncbi.nlm.nih.gov/22393899