Meta-analyses identify DNA methylation associated with kidney function and damage

Autor: Schlosser, Pascal, Tin, Adrienne, Matias-Garcia, Pamela R., Thio, Chris H. L., Joehanes, Roby, Liu, Hongbo, Weihs, Antoine, Yu, Zhi, Hoppmann, Anselm, Grundner-Culemann, Franziska, Min, Josine L., Adeyemo, Adebowale A., Agyemang, Charles, Ärnlöv, Johan, Aziz, Nasir A., Baccarelli, Andrea, Bochud, Murielle, Brenner, Hermann, Breteler, Monique M. B., Carmeli, Cristian, Chaker, Layal, Chambers, John C., Cole, Shelley A., Coresh, Josef, Corre, Tanguy, Correa, Adolfo, Cox, Simon R., de Klein, Niek, Delgado, Graciela E., Domingo-Relloso, Arce, Eckardt, Kai-Uwe, Ekici, Arif B., Endlich, Karlhans, Evans, Kathryn L., Floyd, James S., Fornage, Myriam, Franke, Lude, Fraszczyk, Eliza, Gao, Xu, Gào, Xīn, Ghanbari, Mohsen, Ghasemi, Sahar, Gieger, Christian, Greenland, Philip, Grove, Megan L., Harris, Sarah E., Hemani, Gibran, Henneman, Peter, Herder, Christian, Horvath, Steve, Hou, Lifang, Hurme, Mikko A., Hwang, Shih-Jen, Jarvelin, Marjo-Riitta, Kardia, Sharon L. R., Kasela, Silva, Kleber, Marcus E., Koenig, Wolfgang, Kooner, Jaspal S., Kramer, Holly, Kronenberg, Florian, Kühnel, Brigitte, Lehtimäki, Terho, Lind, Lars, Liu, Dan, Liu, Yongmei, Lloyd-Jones, Donald M., Lohman, Kurt, Lorkowski, Stefan, Lu, Ake T., Marioni, Riccardo E., März, Winfried, McCartney, Daniel L., Meeks, Karlijn A. C., Milani, Lili, Mishra, Pashupati P., Nauck, Matthias, Navas-Acien, Ana, Nowak, Christoph, Peters, Annette, Prokisch, Holger, Psaty, Bruce M., Raitakari, Olli T., Ratliff, Scott M., Reiner, Alex P., Rosas, Sylvia E., Schöttker, Ben, Schwartz, Joel, Sedaghat, Sanaz, Smith, Jennifer A., Sotoodehnia, Nona, Stocker, Hannah R., Stringhini, Silvia, Sundström, Johan, Swenson, Brenton R., Tellez-Plaza, Maria, van Meurs, Joyce B. J., van Vliet-Ostaptchouk, Jana V., Venema, Andrea, Verweij, Niek, Walker, Rosie M., Wielscher, Matthias, Winkelmann, Juliane, Wolffenbuttel, Bruce H. R., Zhao, Wei, Zheng, Yinan, Esko, Tõnu, Metspalu, Andres, Mägi, Reedik, Nelis, Mari, Loh, Marie, Snieder, Harold, Levy, Daniel, Waldenberger, Melanie, Susztak, Katalin, Köttgen, Anna, Teumer, Alexander

Publikováno v: Nature communications, 12(1):7174. Nature Publishing Group
Nature Communications, 12:7174. Nature Publishing Group
Nature communications, vol. 12, no. 1, pp. 7174
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Repisalud
Instituto de Salud Carlos III (ISCIII)
Nature Communications
Nat. Commun. 12:7174 (2021)
Nature Communications, 12(1):7174. Nature Publishing Group
et al. 2021, ' Meta-analyses identify DNA methylation associated with kidney function and damage ', Nature Communications, vol. 12, 7174 (2021) . https://doi.org/10.1038/s41467-021-27234-3
Schlosser, P, Tin, A, Matias-garcia, P R, Thio, C H L, Joehanes, R, Liu, H, Weihs, A, Yu, Z, Hoppmann, A, Grundner-culemann, F, Min, J L, Adeyemo, A A, Agyemang, C, Ärnlöv, J, Aziz, N A, Baccarelli, A, Bochud, M, Brenner, H, Breteler, M M B, Carmeli, C, Chaker, L, Chambers, J C, Cole, S A, Coresh, J, Corre, T, Correa, A, Cox, S R, De Klein, N, Delgado, G E, Domingo-relloso, A, Eckardt, K, Ekici, A B, Endlich, K, Evans, K L, Floyd, J S, Fornage, M, Franke, L, Fraszczyk, E, Gao, X, Gào, X, Ghanbari, M, Ghasemi, S, Gieger, C, Greenland, P, Grove, M L, Harris, S E, Hemani, G, Henneman, P, Herder, C, Horvath, S, Hou, L, Hurme, M A, Hwang, S, Jarvelin, M, Kardia, S L R, Kasela, S, Kleber, M E, Koenig, W, Kooner, J S, Kramer, H, Kronenberg, F, Kühnel, B, Lehtimäki, T, Lind, L, Liu, D, Liu, Y, Lloyd-jones, D M, Lohman, K, Lorkowski, S, Lu, A T, Marioni, R E, März, W, Mccartney, D L, Meeks, K A C, Milani, L, Mishra, P P, Nauck, M, Navas-acien, A, Nowak, C, Peters, A, Prokisch, H, Psaty, B M, Raitakari, O T, Ratliff, S M, Reiner, A P, Rosas, S E, Schöttker, B, Schwartz, J, Sedaghat, S, Smith, J A, Sotoodehnia, N, Stocker, H R, Stringhini, S, Sundström, J, Swenson, B R, Tellez-plaza, M, Van Meurs, J B J, Van Vliet-ostaptchouk, J V, Venema, A, Verweij, N, Walker, R M, Wielscher, M, Winkelmann, J, Wolffenbuttel, B H R, Zhao, W, Zheng, Y, Milani, L, Loh, M, Snieder, H, Levy, D, Waldenberger, M, Susztak, K, Köttgen, A & Teumer, A 2021, ' Meta-analyses identify DNA methylation associated with kidney function and damage ', Nature Communications, vol. 12, no. 1, 7174 . https://doi.org/10.1038/s41467-021-27234-3
Nature Communications 12(1), 7174 (2021). doi:10.1038/s41467-021-27234-3

Chronic kidney disease is a major public health burden. Elevated urinary albumin-to-creatinine ratio is a measure of kidney damage, and used to diagnose and stage chronic kidney disease. To extend the knowledge on regulatory mechanisms related to kid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a666ac8780ee854739b2d4005651ff27
https://pure.amc.nl/en/publications/metaanalyses-identify-dna-methylation-associated-with-kidney-function-and-damage(0b3d0490-c103-42d9-a83e-999de439d3e1).html

Increased compensatory kidney workload results in cellular damage in a short time porcine model of mixed acidemia - Is acidemia a 'first hit' in acute kidney injury?

Autor: Russ, Martin, Ott, Sascha, Bedarf, Janis R., Kirschfink, Michael, Hiebl, Bernhard, Unger, Juliane K.

Publikováno v: PLOS ONE 14(6), e0218308 (2019). doi:10.1371/journal.pone.0218308
PLoS ONE
PLoS ONE, Vol 14, Iss 6, p e0218308 (2019)

Acute kidney injury (AKI) corrupts the outcome of about 50% of all critically ill patients. We investigated the possible contribution of the pathology acidemia on the development of AKI. Pigs were exposed to acidemia, acidemia plus hypoxemia or a nor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6993d01a96784dfa3ea7da71e3ef14eb

Spot urine sodium measurements do not accurately estimate dietary sodium intake in chronic kidney disease

Autor: Dougher, Carly E, Rifkin, Dena E, Anderson, Cheryl Am, Smits, Gerard, Persky, Martha S, Block, Geoffrey A, Ix, Joachim H

Publikováno v: The American journal of clinical nutrition, vol 104, iss 2

Sodium intake influences blood pressure and proteinuria, yet the impact on long-term outcomes is uncertain in chronic kidney disease (CKD). Accurate assessment is essential for clinical and public policy recommendations, but few large-scale studies u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::e5a44cc5d904eef3557a7055211ddb53
https://escholarship.org/uc/item/6bs477v7

The First Scube3 Mutant Mouse Line with Pleiotropic Phenotypic Alterations

Autor: Fuchs, Helmut, Sabrautzki, Sibylle, Przemeck, Gerhard K. H., Leuchtenberger, Stefanie, Lorenz-Depiereux, Bettina, Becker, Lore, Rathkolb, Birgit, Horsch, Marion, Garrett, Lillian, Östereicher, Manuela A., Hans, Wolfgang, Abe, Koichiro, Sagawa, Nobuho, Rozman, Jan, Vargas-Panesso, Ingrid L., Sandholzer, Michael, Lisse, Thomas S., Adler, Thure, Aguilar-Pimentel, Juan Antonio, Calzada-Wack, Julia, Ehrhard, Nicole, Elvert, Ralf, Gau, Christine, Hölter, Sabine M., Micklich, Katja, Moreth, Kristin, Prehn, Cornelia, Puk, Oliver, Racz, Ildiko, Stoeger, Claudia, Vernaleken, Alexandra, Michel, Dian, Diener, Susanne, Wieland, Thomas, Adamski, Jerzy, Bekeredjian, Raffi, Busch, Dirk H., Favor, John, Graw, Jochen, Klingenspor, Martin, Lengger, Christoph, Maier, Holger, Neff, Frauke, Ollert, Markus, Stoeger, Tobias, Yildirim, Ali Önder, Strom, Tim M., Zimmer, Andreas, Wolf, Eckhard, Wurst, Wolfgang, Klopstock, Thomas, Beckers, Johannes, Gailus-Durner, Valerie, Hrabé de Angelis, Martin

Publikováno v: Fuchs, H, Sabrautzki, S, Przemeck, G K H, Leuchtenberger, S, Lorenz-Depiereux, B, Becker, L, Rathkolb, B, Horsch, M, Garrett, L, Östereicher, M A, Hans, W, Abe, K, Sagawa, N, Rozman, J, Vargas-Panesso, I L, Sandholzer, M, Lisse, T S, Adler, T, Aguilar-Pimentel, J A, Calzada-Wack, J, Ehrhard, N, Elvert, R, Gau, C, Hölter, S M, Micklich, K, Moreth, K, Prehn, C, Puk, O, Racz, I, Stöger, C, Vernaleken, A, Michel, D, Diener, S, Wieland, T, Adamski, J, Bekeredjian, R, Busch, D H, Favor, J, Graw, J, Klingenspor, M, Lengger, C, Maier, H, Neff, F, Ollert, M, Stöger, T, Yildirim, A Ö, Strom, T M, Zimmer, A, Wolf, E, Wurst, W, Klopstock, T, Beckers, J, Gailus-Durner, V & Hrabé de Angelis, M 2016, ' The First Scube3 Mutant Mouse Line with Pleiotropic Phenotypic Alterations ', G3: Genes, Genomes, Genetics, vol. 6, no. 12, pp. 4035-4046 . https://doi.org/10.1534/g3.116.033670
G3: Genes|Genomes|Genetics
G3: Genes, Genomes, Genetics, Vol 6, Iss 12, Pp 4035-4046 (2016)
G3: Genes, genomes, genetics 6(12), 4035-4046 (2016). doi:10.1534/g3.116.033670

The vertebrate Scube (Signal peptide, CUB, and EGF-like domain-containing protein) family consists of three independent members, Scube1-3, which encode secreted cell surface-associated membrane glycoproteins. Limited information about the general fun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::fcbc6c5420c8b2bf4f6860cb6ae8052f
https://findresearcher.sdu.dk:8443/ws/files/123549347/The_First_Scube3_Mutant_Mouse_Line_with_Pleiotropic_Phenotypic_Alterations.pdf

Mechanisms of renal NaCl retention in proteinuric disease

Autor: Ole Skøtt, Boye L. Jensen, René Frydensbjerg Andersen, Per Svenningsen, Ulla G. Friis, J. B. Versland, Rikke Zachar, Jan Stener Jørgensen, B. Møller Frederiksen, Kristian B Buhl, Claus Bistrup, Henrik Andersen

Publikováno v: Svenningsen, P, Friis, U G, Versland, J B, Buhl, K B, Frederiksen-Møller, B, Andersen, H, Zachar, R M, Bistrup, C, Skøtt, O, Jørgensen, J S, Andersen, R F & Jensen, B L 2013, ' Mechanisms of renal NaCl retention in proteinuric disease ', Acta Physiologica
, vol. 207, no. 3, pp. 536-545 . https://doi.org/10.1111/apha.12047

In diseases with proteinuria, for example nephrotic syndrome and pre-eclampsia, there often are suppression of plasma renin-angiotensin-aldosterone system components, expansion of extracellular volume and avid renal sodium retention. Mechanisms of so

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e426199f249914df7bd0a7082c67ce0
https://pubmed.ncbi.nlm.nih.gov/23216619