Increased Hippocampal Excitability and Altered Learning Dynamics Mediate Cognitive Mapping Deficits in Human Aging

Autor: Jose P Valdes-Herrera, Claus Tempelmann, Nadine Diersch, Thomas Wolbers

Publikováno v: The Journal of Neuroscience
The journal of neuroscience 41(14), 3204-3221 (2021). doi:10.1523/JNEUROSCI.0528-20.2021

Learning the spatial layout of a novel environment is associated with dynamic activity changes in the hippocampus and in medial parietal areas. With advancing age, the ability to learn spatial environments deteriorates substantially but the underlyin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::555044a61162aaefec2ffdf94ffbcd02
http://europepmc.org/articles/PMC8026345

Microglial activation in the right amygdala-entorhinal-hippocampal complex is associated with preserved spatial learning in App mice

Autor: Florian Eckenweber, Michael Willem, Simon Lindner, Karin Wind, Barbara von Ungern-Sternberg, Sabina Tahirovic, Tanja Blume, Christian Sacher, Peter Bartenstein, Axel Rominger, Michael Ewers, Gloria Biechele, Leonie Beyer, Jochen Herms, Matthias Brendel, Nicolai Franzmeier, Paul Cumming, Franz-Josef Gildehaus, Benedikt Zott

Publikováno v: NeuroImage, Vol 230, Iss, Pp 117707-(2021)
Biechele, Gloria; Wind, Karin; Blume, Tanja; Sacher, Christian; Beyer, Leonie; Eckenweber, Florian; Franzmeier, Nicolai; Ewers, Michael; Zott, Benedikt; Lindner, Simon; Gildehaus, Franz-Josef; von Ungern-Sternberg, Barbara; Tahirovic, Sabina; Willem, Michael; Bartenstein, Peter; Cumming, Paul; Rominger, Axel; Herms, Jochen; Brendel, Matthias (2021). Microglial Activation in the Right Amygdala-Entorhinal-Hippocampal Complex is Associated with Preserved Spatial Learning in AppNL-G-F mice. NeuroImage, 230, p. 117707. Elsevier 10.1016/j.neuroimage.2020.117707
NeuroImage 230, 117707-(2021). doi:10.1016/j.neuroimage.2020.117707

Background In Alzheimer`s disease (AD), regional heterogeneity of β-amyloid burden and microglial activation of individual patients is a well-known phenomenon. Recently, we described a high incidence of inter-individual regional heterogeneity in ter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f35eb65ad65c3291b7844a3892a198a0
https://mediatum.ub.tum.de/1650338

Spatial learning deficits in Parkinson's disease with and without mild cognitive impairment

Autor: Bernd Leplow, Rainer Koch, Sebastian Brown, Alexander Storch, Heinz Reichmann, Katharina Linse, Christine Schneider, Robby Schönfeld

Publikováno v: Parkinsonism & related disorders 36, 83-88 (2017). doi:10.1016/j.parkreldis.2016.12.020

Background Several MRI studies have demonstrated hippocampal atrophy in Parkinson's disease (PD), a structure considered a key element in spatial learning. Despite this, no study has been undertaken to investigate spatial navigation in PD using a vir

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00c4cf65afc620d3d4f85c4ade61571d
https://doi.org/10.1016/j.parkreldis.2016.12.020

Automated radial 8-arm maze: A voluntary and stress-free behavior test to assess spatial learning and memory in mice

Autor: Joel Kohler, Matthias Endres, York Winter, Claudia Spies, Julius V. Emmrich, Jie Mei, Stefanie Banneke

Publikováno v: Behavioural brain research 381, 112352 (2020). doi:10.1016/j.bbr.2019.112352

The radial arm maze (RAM) is a common behavioral test to assess spatial working and reference memory in mice. However, conventional RAM experiments require a substantial degree of manual handling and animals are usually subjected to prolonged periods

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31cdc14c10ac751c5b84af73f751b963
https://pubmed.ncbi.nlm.nih.gov/31722240