Výsledky vyhledávání - "physiology [Protein Transport]"

Protein transport from pre- and postsynapse to the nucleus: Mechanisms and functional implications

Autor: Maria Andres-Alonso, Katarzyna M. Grochowska, Eckart D. Gundelfinger, Anna Karpova, Michael R. Kreutz

Publikováno v: Molecular and cellular neuroscience 125, 103854 (2023). doi:10.1016/j.mcn.2023.103854

The extreme length of neuronal processes poses a challenge for synapse-to-nucleus communication. In response to this challenge several different mechanisms have evolved in neurons to couple synaptic activity to the regulation of gene expression. One

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::708faf9276945b4ccd6be28ce138ca5a

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The Golgi-Associated PDZ Domain Protein Gopc/PIST Is Required for Synaptic Targeting of mGluR5

Autor: Alexander Dityatev, Inseon Song, Malte Klüssendorf, Fabio Morellini, Lynn Schau, Hans-Jürgen Kreienkamp, Judith Koliwer

Publikováno v: Molecular Neurobiology
Molecular neurobiology 58, 5618-5634 (2021). doi:10.1007/s12035-021-02504-9

In neuronal cells, many membrane receptors interact via their intracellular, C-terminal tails with PSD-95/discs large/ZO-1 (PDZ) domain proteins. Some PDZ proteins act as scaffold proteins. In addition, there are a few PDZ proteins such as Gopc which

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4efd6a224e5ae0af900c012afaa95cb6
http://europepmc.org/articles/PMC8599212

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JhI-21 plays a role in Drosophila insulin-like peptide release from larval IPCs via leucine transport

Autor: Ziegler, Anna B., Manière, Gérard, Grosjean, Yael

Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Scientific reports 8(1), 1908 (2018). doi:10.1038/s41598-018-20394-1
Scientific Reports
Scientific Reports, Nature Publishing Group, 2018, 8 (1), ⟨10.1038/s41598-018-20394-1⟩
Scientific Reports, 2018, 8 (1), pp.1908. ⟨10.1038/s41598-018-20394-1⟩

International audience; Insulin is present all across the animal kingdom. Its proper release after feeding is of extraordinary importance for nutrient uptake, regulation of metabolism, and growth. We used Drosophila melanogaster to shed light on the

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http://link.springer.com/article/10.1038/s41598-018-20394-1

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Increased TIMP-3 expression alters the cellular secretome through dual inhibition of the metalloprotease ADAM10 and ligand-binding of the LRP-1 receptor

Autor: Linda Troeberg, Stefan F. Lichtenthaler, Martina Pigoni, Tobias Schätzl, Veronica M. Pravata, Simone D. Scilabra, Stephan A. Müller

Publikováno v: Scientific reports 8(1), 14697 (2018). doi:10.1038/s41598-018-32910-4
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)

The tissue inhibitor of metalloproteinases-3 (TIMP-3) is a major regulator of extracellular matrix turnover and protein shedding by inhibiting different classes of metalloproteinases, including disintegrin metalloproteinases (ADAMs). Tissue bioavaila

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https://ueaeprints.uea.ac.uk/id/eprint/69451/

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Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects

Autor: Matthew E. Kennedy, Peer-Hendrik Kuhn, Stefan F. Lichtenthaler, Philip C. Wong, Robert Vassar, Lawrence Rajendran, Christian Haass

Publikováno v: Journal of neurochemistry 130(1), 4-28 (2014). doi:10.1111/jnc.12715
Journal of Neurochemistry

The β-site APP cleaving enzymes 1 and 2 (BACE1 and BACE2) were initially identified as transmembrane aspartyl proteases cleaving the amyloid precursor protein (APP). BACE1 is a major drug target for Alzheimer's disease because BACE1-mediated cleavag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dd3bb70aae49c27c50e99eccfa8922a
https://doi.org/10.1111/jnc.12715

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Post-translational Membrane Insertion of Tail-anchored Transmembrane EF-hand Ca2+ Sensor Calneurons Requires the TRC40/Asna1 Protein Chaperone

Autor: Vijeta Raghuram, Johannes Hradsky, Marina Mikhaylova, Peter J. McCormick, Michael R. Kreutz, Parameshwar Pasham Reddy, Gemma Navarro, Yogendra Sharma, Mike Hupe, Vicent Casadó

Publikováno v: The journal of biological chemistry 286(42), 36762-36776 (2011). doi:10.1074/jbc.M111.280339

Calneuron-1 and -2 are neuronal EF-hand-type calcium sensor proteins that are prominently targeted to trans-Golgi network membranes and impose a calcium threshold at the Golgi for phosphatidylinositol 4-OH kinase IIIβ activation and the regulated lo

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https://doi.org/10.1074/jbc.m111.280339

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TDP-43 and FUS: a nuclear affair

Autor: Christian Haass, Dorothee Dormann

Publikováno v: Trends in neurosciences 34(7), 339-348 (2011). doi:10.1016/j.tins.2011.05.002

Misfolded TAR DNA binding protein 43 (TDP-43) and Fused-In-Sarcoma (FUS) protein have recently been identified as pathological hallmarks of the neurodegenerative disorders amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTL

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eded261c91757806c4528bcf4f196d1f
https://doi.org/10.1016/j.tins.2011.05.002

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Amyloid-Beta Induced Changes in Vesicular Transport of BDNF in Hippocampal Neurons

Autor: Beat Lutz, Tanja Brigadski, Raik Rönicke, Bianca Seifert, Julia Leschik, Volkmar Lessmann, Klaus G. Reymann, Robert Eckenstaler

Publikováno v: Neural Plasticity
Neural Plasticity, Vol 2016 (2016)
Neural plasticity 2016, 1-15 (2016). doi:10.1155/2016/4145708

The neurotrophin brain derived neurotrophic factor (BDNF) is an important growth factor in the CNS. Deficits in transport of this secretory protein could underlie neurodegenerative diseases. Investigation of disease-related changes in BDNF transport

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08466d6312713baebc71daa7f6d2aa42
https://pubmed.ncbi.nlm.nih.gov/26881108

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Cytoplasmic domain of δ subunit is important for the extra-synaptic targeting of GABAA receptor subtypes

Autor: Ayla Arslan, William Wisden, Jakob von Engelhardt

Publikováno v: Journal of integrative neuroscience 13(04), 617-631 (2014). doi:10.1142/S0219635214500228

GABA(A) receptors (GABA(A)Rs) are hetero-pentameric chloride channels and the primary sites for fast synaptic inhibition. We have expressed recombinant γ2 and δ subunits of GABA(A)Rs in cultured hippocampal neurons to analyze the membrane targeting

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https://pub.dzne.de/record/137670

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Novel diffusion barrier for axonal retention of Tau in neurons and its failure in neurodegeneration

Autor: Li, X., Kumar, Y., Zempel, H., Mandelkow, E., Biernat, J.

Publikováno v: The EMBO journal 30(23), 4825-4837 (2011). doi:10.1038/emboj.2011.376
Embo Journal

Missorting of Tau from axons to the somatodendritic compartment of neurons is a hallmark of Alzheimer's disease, but the mechanisms underlying normal sorting and pathological failure are poorly understood. Here, we used several Tau constructs labelle

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https://pub.dzne.de/record/136362

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