Seizure-mediated iron accumulation and dysregulated iron metabolism after status epilepticus and in temporal lobe epilepsy

Autor: James D. Mills, Eleonora Aronica, Wim Van Hecke, Till S. Zimmer, Stefanie Dedeurwaerdere, Johannes C. Baayen, Sander Idema, Nicole N. van der Wel, Anatoly Korotkov, Jonathan van Eyll, Peter C. van Rijen, Rainer Surges, Erwin A. van Vliet, Helmut W. Kessels, Jan A. Gorter, Diede W. M. Broekaart, Angelika Mühlebner, Martin Schidlowski, Theodor Rüber, Bastian David, Gabriele Ruffolo, Liesbeth François

Publikováno v: Acta Neuropathologica, 142(4), 729-759. Springer Verlag
Acta neuropathologica 142(4), 729-759 (2021). doi:10.1007/s00401-021-02348-6
Acta neuropathologica, 142(4), 729-759. Springer Verlag
Acta Neuropathologica

Neuronal dysfunction due to iron accumulation in conjunction with reactive oxygen species (ROS) could represent an important, yet underappreciated, component of the epileptogenic process. However, to date, alterations in iron metabolism in the epilep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b82eaadc30bc3f4a002607a77dba8b4
https://doi.org/10.1007/s00401-021-02348-6

Neuroprotection in acute stroke: targeting excitotoxicity, oxidative and nitrosative stress, and inflammation

Autor: Xabier Urra, Ángel Chamorro, Ulrich Dirnagl, Anna M. Planas

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
The lancet / Neurology 15(8), 869-881 (2016). doi:10.1016/S1474-4422(16)00114-9

Treatments for acute ischaemic stroke continue to evolve after the superior value of endovascular thrombectomy was confirmed over systemic thrombolysis. Unfortunately, numerous neuroprotective drugs have failed to show benefit in the treatment of acu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b70972b31ccda87c2df193ff7652ada5
https://doi.org/10.1016/s1474-4422(16)00114-9

DJ-1 is a redox sensitive adapter protein for high molecular weight complexes involved in regulation of catecholamine homeostasis

Autor: Dominik Piston, Lydia Alvarez-Erviti, Vikas Bansal, Daniela Gargano, Zhi Yao, Gyorgy Szabadkai, Mark Odell, M Rhyan Puno, Benny Björkblom, Jodi Maple-Grødem, Peter Breuer, Oliver Kaut, Jan Petter Larsen, Stefan Bonn, Simon Geir Møller, Ullrich Wüllner, Anthony H V Schapira, Matthew E Gegg

Publikováno v: Human molecular genetics 26(20), 4028-4041 (2017). doi:10.1093/hmg/ddx294
Human Molecular Genetics

DJ-1 is an oxidation sensitive protein encoded by the PARK7 gene. Mutations in PARK7 are a rare cause of familial recessive Parkinson's disease (PD), but growing evidence suggests involvement of DJ-1 in idiopathic PD. The key clinical features of PD,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::589ee14d3b19c486a0ae29a58189184b
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-140877

Tracking CNS and systemic sources of oxidative stress during the course of chronic neuroinflammation

Autor: Josephine Herz, Agata Mossakowski, Helena Radbruch, Josef Priller, Michael Boschmann, Markus Bock, Leonard Viohl, Jenny Gerhard, Karolin Pollok, Moritz Radbruch, Florence Pache, Carmen Infante-Duarte, Anja Mähler, Janina Behrens, Daniel Bremer, Randall L. Lindquist, Raluca Niesner, Anja E. Hauser, Markus Bardua, Martina Füchtemeier, Julian Pohlan, Judith Bellmann-Strobl, Ronja Mothes, Jan Leo Rinnenthal, Friedemann Paul, Jason M. Millward

Publikováno v: Acta neuropathologica 130(6), 799-814 (2015). doi:10.1007/s00401-015-1497-x
Acta Neuropathologica
Mossakowski, A A, Pohlan, J, Bremer, D, Lindquist, R, Millward, J M, Bock, M, Pollok, K, Mothes, R, Viohl, L, Radbruch, M, Gerhard, J, Bellmann-Strobl, J, Behrens, J, Infante-Duarte, C, Mähler, A, Boschmann, M, Rinnenthal, J L, Füchtemeier, M, Herz, J, Pache, F C, Bardua, M, Priller, J, Hauser, A E, Paul, F, Niesner, R & Radbruch, H 2015, ' Tracking CNS and systemic sources of oxidative stress during the course of chronic neuroinflammation ', Acta Neuropathologica, vol. 130, no. 6, pp. 799-814 . https://doi.org/10.1007/s00401-015-1497-x

The functional dynamics and cellular sources of oxidative stress are central to understanding MS pathogenesis but remain elusive, due to the lack of appropriate detection methods. Here we employ NAD(P)H fluorescence lifetime imaging to detect functio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2959d06d699d7087efdfe9b712adf23a
https://pub.dzne.de/record/138235

Lewy body pathology is associated with mitochondrial DNA damage in Parkinson's disease

Autor: Sarina K. Müller, Thomas Klopstock, Andreas Bender, Falk Schlaudraff, Birgit Liss, Tobias Högen, Christoph Laub, Matthias Elstner

Publikováno v: Neurobiology of aging 34(9), 2231-2233 (2013). doi:10.1016/j.neurobiolaging.2013.03.016

Mitochondrial dysfunction has been strongly implicated in the pathogenesis of Parkinson's disease (PD) and Alzheimer's disease (AD), but its relation to protein aggregation is unclear. PD is characterized by synuclein aggregation (i.e., Lewy body (LB

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f9740caf8a92f0207791f60a45977bc