Výsledky vyhledávání - "physiology [Nerve Tissue Proteins]"

Calcium-Independent Exo-endocytosis Coupling at Small Central Synapses

Autor: Dietmar Schmitz, Christian Rosenmund, Melissa A. Herman, Marta Orlando

Publikováno v: Cell Reports, Vol 29, Iss 12, Pp 3767-3774.e3 (2019)
Cell reports 29(12), 3767-3774.e3 (2019). doi:10.1016/j.celrep.2019.11.060

Summary: At presynaptic terminals, neurotransmitters are released by synaptic vesicle exocytosis at the active zone. In order to maintain efficient neurotransmission and proper synaptic structure, sites of vesicle fusion must be cleared rapidly by en

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd3c34b5845e28d806fbd1f5fe5c25f9
http://www.sciencedirect.com/science/article/pii/S2211124719315517

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Activation of the medial preoptic area (MPOA) ameliorates loss of maternal behavior in a Shank2 mouse model for autism

Autor: Kevin Thome, Carolina Urrutia-Ruiz, Stefanie Grabrucker, Carlo Sala, Günter Ehret, Johanna Schweizer, Andreas M. Grabrucker, Tobias M. Boeckers, Michael Schön, Rong Zhang, Juergen Bockmann, Bastian Hengerer, Jessica Pagano, Chiara Verpelli

Publikováno v: The EMBO journal 40(5), e104267 (2021). doi:10.15252/embj.2019104267
The EMBO Journal

Impairments in social relationships and awareness are features observed in autism spectrum disorders (ASDs). However, the underlying mechanisms remain poorly understood. Shank2 is a high��confidence ASD candidate gene and localizes primarily t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a338e9ab894eff16eec4c405d9ab335c

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CRMP2 mediates Sema3F-dependent axon pruning and dendritic spine remodeling

Autor: Martin Balastik, Eran Perlson, Romana Weissova, Roy Maimon, Thomas Misgeld, Tomas Petrasek, Marie Kleisnerova, Radislav Sedlacek, Jakub Ziak, Barbora Pukajova, Monika S. Brill, Mengzhe Wang, Xunlei Zhou, Ales Stuchlik, Gonzalo Alvarez-Bolado, Petr Kasparek, Kateřina Jeřábková, Martina Janikova

Publikováno v: EMBO reports 21(3), e48512 (2020). doi:10.15252/embr.201948512
EMBO Rep

Regulation of axon guidance and pruning of inappropriate synapses by class 3 semaphorins is key to development of neural circuits. Collapsin response mediator protein 2 (CRMP2) has been shown to regulate axon guidance by mediating Semaphorin 3A (Sema

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a56216d97953369ea91f656705aad9e2
https://doi.org/10.1101/719617

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Genome-wide analyses as part of the international FTLD-TDP whole-genome sequencing consortium reveals novel disease risk factors and increases support for immune dysfunction in FTLD

Autor: Nigel J. Cairns, Merel O. Mol, Gregory D. Jenkins, Leonard Petrucelli, Nilufer Ertekin-Taner, Stuart Pickering-Brown, Carlos Cruchaga, Edward B. Lee, Jonathan D. Glass, John C. van Swieten, Jonathan D. Rohrer, Keith A. Josephs, Patrizia Rizzu, Johannes Prudlo, Edward D. Huey, Cristina T. Vicente, Shulan Tian, Claire Troakes, Ging-Yuek Robin Hsiung, Julie S. Snowden, Lawrence S. Honig, Jean Paul G. Vonsattel, Yan W. Asmann, Matthis Synofzik, Sigrun Roeber, Jeroen van Rooij, Ralph B. Perkerson, Eric M. Reiman, Charles L. White, Ethan G. Geier, Billie J. Matchett, Robert A. Rissman, Julia Keith, David J. Irwin, Manuela Neumann, Dieter Edbauer, M.-Marsel Mesulam, Jochen Herms, Vivianna M. Van Deerlin, Jordan Grafman, Melissa E. Murray, Oscar L. Lopez, Bernardino Ghetti, Rosa Rademakers, Bradley F. Boeve, Ekaterina Rogaeva, Sara Rollinson, Marla Gearing, Geoffrey L. Ahern, Zachary C. Fogarty, Peter Heutink, Yingxue Ren, Javier Simón-Sánchez, David G. Mann, Bryan K. Woodruff, Ryan J. Uitti, Martin R. Farlow, Lea T. Grinberg, Murray Grossman, Julia Kofler, Ian R. A. Mackenzie, Jennifer S. Yokoyama, Lorne Zinman, Matt Baker, John Q. Trojanowski, Zbigniew K. Wszolek, Cyril Pottier, Changiz Geula, Thomas Arzberger, Dennis W. Dickson, Joanna M. Biernacka, William W. Seeley, Caroline Graff, Olivier Piguet, John B.J. Kwok, Joseph E. Parisi, Safa Al-Sarraj, Harro Seelaar, Elizabeth Christopher, Ronald C. Petersen, Linn Öijerstedt, Anna Karydas, Salvatore Spina, Carlo Wilke, Marka van Blitterswijk, Simon Mead, Janine Diehl-Schmid, Bret M. Evers, David S. Knopman, Kevin F. Bieniek, John R. Hodges, Anthony Batzler, Mariely DeJesus-Hernandez, Elizabeth Finger, Thomas G. Beach, EunRan Suh, Maria Carmela Tartaglia, Sandra Weintraub, Shannon K. McDonnell, Bruce L. Miller, Glenda M. Halliday, Andy King, Eileen H. Bigio, Neill R. Graff-Radford, Richard J. Caselli

Publikováno v: Acta Neuropathologica, 137(6), 879-899. Springer-Verlag
Acta Neuropathol
Acta neuropathologica 137(6), 879-899 (2019). doi:10.1007/s00401-019-01962-9
Acta neuropathologica

Frontotemporal lobar degeneration with neuronal inclusions of the TAR DNA-binding protein 43 (FTLD-TDP) represents the most common pathological subtype of FTLD. We established the international FTLD-TDP whole-genome sequencing consortium to thoroughl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1500c504ddc41a67b8cb5e111941d5d5
https://pure.eur.nl/en/publications/ec4efc7a-1a6b-4346-af9a-7b821d069c4d

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Defective Synapse Maturation and Enhanced Synaptic Plasticity in Shank2 Δex7-/- Mice

Autor: Arne Buschler, Sarah A. Shoichet, Chae-Seok Lim, Stephanie Wegener, Denise Manahan-Vaughan, Bong-Kiun Kaang, Sukjae Joshua Kang, A. Vanessa Stempel, Dietmar Schmitz

Publikováno v: eNeuro 5(3), ENEURO.0398-17.2018 (2018). doi:10.1523/ENEURO.0398-17.2018
eNeuro

Visual Abstract
Autism spectrum disorders (ASDs) are neurodevelopmental disorders with a strong genetic etiology. Since mutations in human SHANK genes have been found in patients with autism, genetic mouse models are used for a mechanistic under

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f2100f9d2faa3afd1ae792b20a199b1
https://pub.dzne.de/record/141133

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Ablation of the presynaptic organizer Bassoon in excitatory neurons retards dentate gyrus maturation and enhances learning performance

Autor: Eckart D. Gundelfinger, Wolfgang Tischmeyer, Sabrina Müller, Frank Angenstein, Eike Budinger, Anna Fejtova, Dirk Montag, Gürsel Çalışkan, Anil Annamneedi, Oliver Stork

Publikováno v: Brain structure & function 223(7), 3423-3445 (2018). doi:10.1007/s00429-018-1692-3
Brain Structure & Function
Brain structure & function, 223(7):3423-3445

Bassoon is a large scaffolding protein of the presynaptic active zone involved in the development of presynaptic terminals and in the regulation of neurotransmitter release at both excitatory and inhibitory brain synapses. Mice with constitutive abla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1783b1152bc05f81496da78ea2aee22c

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GDAP2 mutations implicate susceptibility to cellular stress in a new form of cerebellar ataxia

Autor: Lisa van Ninhuijs, Jean Jacques Martin, Jonathan Baets, Annette Schenck, Erik-Jan Kamsteeg, Bart P.C. van de Warrenburg, Tine Deconinck, Rebecca Schüle, Stephan Züchner, Ilse Eidhof, Peter De Jonghe

Publikováno v: Brain
Brain, 141, 9, pp. 2592-2604
Brain, 141, 2592-2604
Brain 141(9), 2592-2604 (2018). doi:10.1093/brain/awy198

Eidhofet al. report a new subtype of autosomal recessive cerebellar ataxia caused by mutations inGDAP2, and show thatGdap2 knockdown inDrosophila recapitulates locomotor dysfunction and shortened lifespan. Susceptibility to cellular stress in theGdap

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dec1f10d731474e399aef06d6c71527
https://hdl.handle.net/10067/1547910151162165141

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Microtubule Organization in the Axon: TRIM46 Determines the Orientation

Autor: Michele Curcio, Frank Bradke

Publikováno v: Neuron 88(6), 1072-1074 (2015). doi:10.1016/j.neuron.2015.12.006

The microtubule cytoskeleton is a major determinant in neuronal polarity. In this issue of Neuron, van Beuningen et al. (2015) now report that TRIM46 forms parallel microtubule bundles in the proximal axon and reveal that it is crucial for the establ

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RIM3γ and RIM4γ Are Key Regulators of Neuronal Arborization

Autor: Elena Alvarez-Baron, Thoralf Opitz, Tobias Mittelstaedt, Susanne Schoch, Katrin Michel, Heinz Beck, Dirk Dietrich, Albert J. Becker, Frank Schmitz

Publikováno v: The journal of neuroscience 33(2), 824-839 (2013). doi:10.1523/JNEUROSCI.2229-12.2013

The large isoforms of the Rab3 interacting molecule (RIM) family, RIM1α/β and RIM2α/β, have been shown to be centrally involved in mediating presynaptic active zone function. The RIM protein family contains two additional small isoforms, RIM3γ a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68c2c725a266f0baa61bd32903ff7acf
https://doi.org/10.1523/jneurosci.2229-12.2013

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Region and task-specific activation of Arc in primary motor cortex of rats following motor skill learning

Autor: S. Mann, Jonas A. Hosp, Michael E. Calhoun, Bettina M. Wegenast-Braun, A.R. Luft

Publikováno v: Neuroscience 250, 557-564 (2013). doi:10.1016/j.neuroscience.2013.06.060
Neuroscience

Motor learning requires protein synthesis within the primary motor cortex (M1). Here, we show that the immediate early gene Arc/Arg3.1 is specifically induced in M1 by learning a motor skill. Arc mRNA was quantified using a fluorescent in situ hybrid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3758e6bed48ef6228bf96a1c5a66f157
https://pub.dzne.de/record/137050

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