Výsledky vyhledávání - "physiology [Mitochondria]"

Imaging of neuronal mitochondria in situ

Autor: Gabriela Plucińska, Thomas Misgeld

Publikováno v: Current opinion in neurobiology 39, 152-163 (2016). doi:10.1016/j.conb.2016.06.006

Neuronal mitochondria are receiving a rapidly increasing level of attention. This is to a significant part due to the ability to visualize neuronal mitochondria in novel ways, especially in vivo. Such an approach allows studying neuronal mitochondria

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68751d4e066deaaf6ad1dba2e3a0daf0
https://doi.org/10.1016/j.conb.2016.06.006

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6-Hydroxydopamine impairs mitochondrial function in the rat model of Parkinson’s disease: respirometric, histological, and behavioral analyses

Autor: Frank Striggow, Grazyna Debska-Vielhaber, Jürgen Voges, Frank N. Gellerich, Patricia Panther, Andreas Kupsch, Stefan Vielhaber, Hans-Jochen Heinze, Herbert Schwegler, Werner Schmidt, Zemfira Gizatullina

Publikováno v: Journal of neural transmission 121(10), 1245-1257 (2014). doi:10.1007/s00702-014-1185-3

Mitochondrial defects have been shown to be associated with the pathogenesis of Parkinson's disease (PD). Yet, experience in PD research linking mitochondrial dysfunction, e.g., deregulation of oxidative phosphorylation, with neuronal degeneration an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f4d1b2a6a297acea61985b3f5fc84e4
https://doi.org/10.1007/s00702-014-1185-3

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Imaging Subcellular Structures in the Living Zebrafish Embryo

Autor: Rachel Thong, Dominik Paquet, Gabriela Plucińska, Peter Engerer, Laura Trovò, Leanne Godinho

Publikováno v: JoVE journal Developmental Biology(110), 53456 (2016). doi:10.3791/53456

In vivo imaging provides unprecedented access to the dynamic behavior of cellular and subcellular structures in their natural context. Performing such imaging experiments in higher vertebrates such as mammals generally requires surgical access to the

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https://pubmed.ncbi.nlm.nih.gov/27078038

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The ubiquitin-conjugating enzymes UBE2N, UBE2L3 and UBE2D2/3 are essential for Parkin-dependent mitophagy

Autor: Geisler, Sven, Vollmer, Stefanie, Golombek, Sonia, Kahle, Philipp J

Publikováno v: Journal of cell science 127(15), 3280-3293 (2014). doi:10.1242/jcs.146035

Depolarized mitochondria are degraded by mitophagy in a process that depends on the Parkinson's disease gene products PINK1 and Parkin. This is accompanied by ubiquitylation of several mitochondrial substrates. The roles of E2 ubiquitin-conjugating e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::966a0427a0c799f754fe29e70d446109
https://pubmed.ncbi.nlm.nih.gov/24906799

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Enhancing nucleotide metabolism protects against mitochondrial dysfunction and neurodegeneration in a PINK1 model of Parkinson’s disease

Autor: Giovanna R. Mallucci, Sonia Gandhi, David Dinsdale, Plamena R. Angelova, Andrey Y. Abramov, Anne E. Willis, Roberta Tufi, Helene Plun-Favreau, Inês Pimenta de Castro, L. Miguel Martins, Samantha H. Y. Loh, Emma Deas, Susann Lehmann, Pierluigi Nicotera

Publikováno v: Nature cell biology 16(2), 157-166 (2014). doi:10.1038/ncb2901

Mutations in PINK1 cause early-onset Parkinson's disease (PD). Studies in Drosophila melanogaster have highlighted mitochondrial dysfunction on loss of Pink1 as a central mechanism of PD pathogenesis. Here we show that global analysis of transcriptio

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https://europepmc.org/articles/PMC4199097/

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In vivo imaging of mitochondria in intact zebrafish larvae

Autor: Dominik, Paquet, Gabriela, Plucińska, Thomas, Misgeld

Publikováno v: Methods in enzymology 547, 151-164 (2014). doi:10.1016/B978-0-12-801415-8.00009-6
Mitochondrial Function / Paquet, Dominik ; : Elsevier, 2014, ; ISSN: 00766879 ; ISBN: 9780128014158 ; doi:10.1016/B978-0-12-801415-8.00009-6

Visualizing neuronal mitochondria in a living, intact mammalian organism is a challenge that can be overcome in zebrafish larvae, which are highly accessible for optical imaging and genetic manipulation. Here, we detail an approach to visualize neuro

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https://pub.dzne.de/record/138716

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CNS axons globally increase axonal transport after peripheral conditioning

Autor: Mónica Mendes Sousa, Inês S. Rodrigo, Sergio Roberto de Andrade Leite, Thomas Misgeld, Carla Teixeira, Fernando M. Mar, Marlene M. Morgado, Anabel R. Simões, Telma Emanuela Santos

Publikováno v: The journal of neuroscience 34(17), 5965-5970 (2014). doi:10.1523/JNEUROSCI.4680-13.2014

Despite the inability of CNS axons to regenerate, an increased regenerative capacity can be elicited following conditioning lesion to the peripheral branch of dorsal root ganglia neurons (DRGs). Byin vivoradiolabeling of rat DRGs, coupled to mass spe

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https://pub.dzne.de/record/137365

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Multiparametric optical analysis of mitochondrial redox signals during neuronal physiology and pathology in vivo

Autor: Tobias P. Dick, Ronald Naumann, Oliver Griesbeck, Petar Marinković, Franz M. J. Pfister, Peter M.J. Bradley, Barbara Plomer, Martin Kerschensteiner, Anja Schmalz, Daret K. St. Clair, Markus Schwarzländer, Leanne Godinho, Philip R. Williams, Thomas Misgeld, Michael O. Breckwoldt, Monika S. Brill, Florence M. Bareyre

Publikováno v: Nature Medicine
Nature medicine 20(5), 555-560 (2014). doi:10.1038/nm.3520

Mitochondrial redox signals have a central role in neuronal physiology and disease. Here we describe a new optical approach to measure fast redox signals with single-organelle resolution in living mice that express genetically encoded redox biosensor

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https://pubmed.ncbi.nlm.nih.gov/24747747

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Tricarboxylic acid cycle-sustained oxidative phosphorylation in isolated myelin vesicles

Autor: Martina Bartolucci, Alessandro Morelli, Silvia Ravera, Paola Ramoino, Maria Grazia Aluigi, Daniela Calzia, Isabella Panfoli

The Central Nervous System (CNS) function was shown to be fueled exclusively by oxidative phosphorylation (OXPHOS). This is in line with the sensitivity of brain to hypoxia, but less with the scarcity of the mitochondria in CNS. Consistently with the

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https://hdl.handle.net/11567/748591

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Mitofusin 2 mutations affect mitochondrial function by mitochondrial DNA depletion

Autor: Irina Minin, Reinhard Dengler, Viktoriya Peeva, Grazyna Debska-Vielhaber, Gábor Zsurka, Wolfram S. Kunz, Katja Kollewe, Cornelia Kornblum, Susanne Schoeler, Werner Zuschratter, Alexei P. Kudin, Stefan Vielhaber, Stefanie Schreiber

Publikováno v: Acta neuropathologica 125(2), 245-256 (2012). doi:10.1007/s00401-012-1036-y

Charcot-Marie-Tooth neuropathy type 2A (CMT2A) is associated with heterozygous mutations in the mitochondrial protein mitofusin 2 (Mfn2) that is intimately involved with the outer mitochondrial membrane fusion machinery. The precise consequences of t

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