Zobrazeno 1 - 10
of 29
pro vyhledávání: '"physiology [Microglia]"'
Autor:
Nebeling, Felix Christopher, Poll, Stefanie, Justus, Lena Christine, Steffen, Julia, Keppler, Kevin, Mittag, Manuel, Fuhrmann, Martin
Publikováno v:
eLife 12, e83176 (2023). doi:10.7554/eLife.83176
Microglia, the resident immune cells of the brain, play a complex role in health and disease. They actively survey the brain parenchyma by physically interacting with other cells and structurally shaping the brain. Yet, the mechanisms underlying micr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ae378542f1328423466e5a760e08623
https://doi.org/10.7554/elife.83176
https://doi.org/10.7554/elife.83176
Publikováno v:
Trends in molecular medicine 27(1), 47-59 (2021). doi:10.1016/j.molmed.2020.09.001
Microglia have long been considered a homogenous cell population that uniformly responds to extrinsic factors. Here, we describe how the recent development of single-cell technologies has revealed the heterogeneity of both human and mouse microglia a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94a22c990527363f3ff877fc2279fc5b
https://doi.org/10.1016/j.molmed.2020.09.001
https://doi.org/10.1016/j.molmed.2020.09.001
Autor:
Anika Reifschneider, Sophie Robinson, Bettina van Lengerich, Johannes Gnörich, Todd Logan, Steffanie Heindl, Miriam A Vogt, Endy Weidinger, Lina Riedl, Karin Wind, Artem Zatcepin, Ida Pesämaa, Sophie Haberl, Brigitte Nuscher, Gernot Kleinberger, Julien Klimmt, Julia K Götzl, Arthur Liesz, Katharina Bürger, Matthias Brendel, Johannes Levin, Janine Diehl‐Schmid, Jung Suh, Gilbert Di Paolo, Joseph W Lewcock, Kathryn M Monroe, Dominik Paquet, Anja Capell, Christian Haass
Publikováno v:
The EMBO journal 41(4), e109108 (2022). doi:10.15252/embj.2021109108
Haploinsufficiency of the progranulin (PGRN)-encoding gene (GRN) causes frontotemporal lobar degeneration (GRN-FTLD) and results in microglial hyperactivation, TREM2 activation, lysosomal dysfunction, and TDP-43 deposition. To understand the contribu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::561d67316e9f278a34f08b959e8dd608
https://pub.dzne.de/record/163471
https://pub.dzne.de/record/163471
Autor:
Emma L. van der Ende, Corey T. McMillan, John C. van Swieten, Christian Haass, Rik Vandenberghe, Murray Grossman, Isabelle Le Ber, Marc Suárez-Calvet, Estrella Morenas-Rodríguez, Robert Laforce, David J. Irwin, Alberto Lleó, Raquel Sánchez-Valle, Harro Seelaar, Yolande A.L. Pijnenburg, Caroline Graff
Publikováno v:
Neurobiology of Aging
Neurobiology of Aging, Elsevier, 2021, ⟨10.1016/j.neurobiolaging.2021.02.024⟩
Neurobiology of Aging, 2021, ⟨10.1016/j.neurobiolaging.2021.02.024⟩
van der Ende, E L, Morenas-Rodriguez, E, McMillan, C, Grossman, M, Irwin, D, Sanchez-Valle, R, Graff, C, Vandenberghe, R, Pijnenburg, Y A L, Laforce, R, Ber, I L, Lleo, A, Haass, C, Suarez-Calvet, M, van Swieten, J C & Seelaar, H 2021, ' CSF sTREM2 is elevated in a subset in GRN-related frontotemporal dementia ', Neurobiology of Aging, vol. 103, pp. 158.e1-158.e5 . https://doi.org/10.1016/j.neurobiolaging.2021.02.024
Neurobiology of aging 103, 158.e1-158.e5 (2021). doi:10.1016/j.neurobiolaging.2021.02.024
Neurobiology of Aging, 103, 158.e1-158.e5. Elsevier Inc.
NEUROBIOLOGY OF AGING
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
Instituto de Salud Carlos III (ISCIII)
Neurobiology of Aging, Elsevier, 2021, ⟨10.1016/j.neurobiolaging.2021.02.024⟩
Neurobiology of Aging, 2021, ⟨10.1016/j.neurobiolaging.2021.02.024⟩
van der Ende, E L, Morenas-Rodriguez, E, McMillan, C, Grossman, M, Irwin, D, Sanchez-Valle, R, Graff, C, Vandenberghe, R, Pijnenburg, Y A L, Laforce, R, Ber, I L, Lleo, A, Haass, C, Suarez-Calvet, M, van Swieten, J C & Seelaar, H 2021, ' CSF sTREM2 is elevated in a subset in GRN-related frontotemporal dementia ', Neurobiology of Aging, vol. 103, pp. 158.e1-158.e5 . https://doi.org/10.1016/j.neurobiolaging.2021.02.024
Neurobiology of aging 103, 158.e1-158.e5 (2021). doi:10.1016/j.neurobiolaging.2021.02.024
Neurobiology of Aging, 103, 158.e1-158.e5. Elsevier Inc.
NEUROBIOLOGY OF AGING
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
Instituto de Salud Carlos III (ISCIII)
Altres ajuts: Deltaplan Dementie (The Netherlands Organisation for Health Research and Development and Alzheimer Nederland grant numbers 7330550813, 733050103); Dioraphte Foundation (grant number 1402 1300); the European Joint Programme - Neurodegene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d61b7a91880f67d3fd7ebd6297416e0
http://hdl.handle.net/20.500.12278/35851
http://hdl.handle.net/20.500.12278/35851
Autor:
Lena Spieth, Roman Sankowski, David Ewers, Martin Meschkat, Stefan A. Berghoff, Mikael Simons, Jan Winchenbach, Ting Sun, Julia M. Edgar, Gesine Saher, Torben Ruhwedel, Ludovico Cantuti-Castelvetri, Christine Stadelmann-Nessler, Franziska van der Meer, Francesca Odoardi, Wiebke Möbius, Tim Düking, Klaus-Armin Nave, Michael W. Sereda, Patricia Scholz, Constanze Depp, Lennart Schlaphoff, Marco Prinz, Jonathan Neuber, Andrew Octavian Sasmita, Inge Huitinga, Till Ischebeck, Leon Hosang
Publikováno v:
Nature Neuroscience, 24, 47-60. Nature Publishing Group
Nature neuroscience.
Nature neuroscience 24(1), 47-60 (2021). doi:10.1038/s41593-020-00757-6
Nature neuroscience
Nature neuroscience.
Nature neuroscience 24(1), 47-60 (2021). doi:10.1038/s41593-020-00757-6
Nature neuroscience
The repair of inflamed, demyelinated lesions as in multiple sclerosis (MS) necessitates the clearance of cholesterol-rich myelin debris by microglia/macrophages and the switch from a pro-inflammatory to an anti-inflammatory lesion environment. Subseq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3611e48234b6ab2743ff34a0d63b70e8
https://pure.knaw.nl/portal/en/publications/99839925-2317-482f-84d3-35ccaca51264
https://pure.knaw.nl/portal/en/publications/99839925-2317-482f-84d3-35ccaca51264
Autor:
Tobias Goldmann, Fabio M.V. Rossi, Chotima Böttcher, Peipei Zhang, Jana Koch, Stefaniya Boneva, Ingo Hilgendorf, Ori Staszewski, Takahiro Masuda, Lukas Amann, Peter Wieghofer, Nora Hagemeyer, Josef Priller, Marco Prinz, Roman Sankowski, Clemens Lange, Annika Hausmann, Anja Schlecht, Markus Gruber
Publikováno v:
The EMBO journal 40(6), e105123 (2021). doi:10.15252/embj.2020105123
The EMBO Journal
The EMBO Journal
Similar to the brain, the eye is considered an immune‐privileged organ where tissue‐resident macrophages provide the major immune cell constituents. However, little is known about spatially restricted macrophage subsets within different eye compa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74ee3b794f53aa607cbde5c2fe0c798b
https://pub.dzne.de/record/164200
https://pub.dzne.de/record/164200
Publikováno v:
eLife 9, e58435 (2020). doi:10.7554/eLife.58435
eLife, Vol 9 (2020)
eLife
eLife, Vol 9 (2020)
eLife
Microglia continuously monitor synapses, but active synaptic remodeling by microglia in mature healthy brains is rarely directly observed. We performed targeted photoablation of single synapses in mature transgenic mice expressing fluorescent labels
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::0db85b5bc6d8c7df1f361c8a493f571f
https://pub.dzne.de/record/153454
https://pub.dzne.de/record/153454
Autor:
Christian Witzel, Roland E. Kälin, Frank L. Heppner, Kelly R. Miller, Stefanie Kälin, Marina Jendrach
Publikováno v:
The journal of clinical investigation 128(7), 2774-2786 (2018). doi:10.1172/JCI95305
Activation of non-neuronal microglia is thought to play a causal role in spinal processing of neuropathic pain. To specifically investigate microglia-mediated effects in a model of neuropathic pain and overcome the methodological limitations of previ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a6cb036cb8a86be6043445cd50b0d8b
https://doi.org/10.1172/jci95305
https://doi.org/10.1172/jci95305
Autor:
Jochen Herms, Nathalie L. Albert, Federico Probst, Maximilian Deussing, Barbara von Ungern-Sternberg, Tanja Blume, Carola Focke, Peter Bartenstein, Felix Overhoff, Simon Lindner, Finn Peters, Matthias Brendel, Christian Haass, Axel Rominger, Gernot Kleinberger, Anna Jaworska
Publikováno v:
Journal of nuclear medicine 58(12), 1984-1990 (2017). doi:10.2967/jnumed.117.195107
Contrary to findings in the human brain, 18F-FDG PET shows cerebral hypermetabolism of aged wild-type (WT) mice relative to younger animals, supposedly due to microglial activation. Therefore, we used dual-tracer small-animal PET to examine directly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d8f291b0d6d28eb7927914164fc10b8
https://doi.org/10.2967/jnumed.117.195107
https://doi.org/10.2967/jnumed.117.195107
Publikováno v:
Cell 179(2), 292-311 (2019). doi:10.1016/j.cell.2019.08.053
Microglia were first recognized as a distinct cell population in the CNS one century ago. For a long time, they were primarily considered to be phagocytes responsible for removing debris during CNS development and disease. More recently, advances in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56cd80219e17839add40396b0f519a8f
https://pubmed.ncbi.nlm.nih.gov/31585077
https://pubmed.ncbi.nlm.nih.gov/31585077