Výsledky vyhledávání - "physiology [Metalloendopeptidases]"

Meprin β cleaves TREM2 and controls its phagocytic activity on macrophages

Autor: Gernot Kleinberger, Christian Haass, Fred Armbrust, Janna Schneppenheim, Dennis Kristopher Berner, Andreas Tholey, Ralph Lucius, Philipp Arnold, Kai Schlepckow, Tomas Koudelka, Franka Scharfenberg, Christoph Becker-Pauly, Luisa Wessolowski

Publikováno v: The FASEB journal 34(5), 6675-6687 (2020). doi:10.1096/fj.201902183R

The triggering receptor expressed on myeloid cells 2 (TREM2) is a multifunctional surface protein that affects survival, migration, and phagocytic capacity of myeloid cells. Soluble TREM2 levels were found to be increased in early stages of sporadic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2efd92d4a78dc7c9c7d36606c5819495
https://pubmed.ncbi.nlm.nih.gov/32237095

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Nardilysin prevents amyloid plaque formation by enhancing α-secretase activity in an Alzheimer's disease mouse model

Autor: Wataru Araki, Toru Kita, Ryosuke Takahashi, Sayaka Saijo, Kiyoto Nishi, Takeshi Kimura, Eiichiro Nishi, Stefan F. Lichtenthaler, Hidekazu Tomimoto, Yoshinori Hiraoka, Tatsuhiko Matsuoka, Mikiko Ohno

Publikováno v: Neurobiology of aging 35(1), 213-222 (2014). doi:10.1016/j.neurobiolaging.2013.07.014

Amyloid beta (Aβ) peptide, the main component of senile plaques in patients with Alzheimer's disease (AD), is derived from proteolytic cleavage of amyloid precursor protein (APP) by β- and γ-secretases. Alpha-cleavage of APP by α-secretase has a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f459f6363421f016701b81396ad78adc
https://pubmed.ncbi.nlm.nih.gov/24099785

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P-selectin glycoprotein ligand 1 is a ligand for L-selectin on neutrophils, monocytes, and CD34+ hematopoietic progenitor cells

Autor: Olivier Spertini, L. Giuffrè, A.-S. Cordey, Marc Schapira, N. Monai

Publikováno v: Journal of Cell Biology, vol. 135, no. 2, pp. 523-531
The Journal of Cell Biology

Selectins play a critical role in initiating leukocyte binding to vascular endothelium. In addition, in vitro experiments have shown that neutrophils use L-selectin to roll on adherent neutrophils, suggesting that they express a nonvascular L-selecti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e45c6e60fda86b835479faa001b0aec
https://serval.unil.ch/notice/serval:BIB_23A7D5F56FB1

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