Výsledky vyhledávání - "physiology [Induced Pluripotent Stem Cells]"

Interferon-γ signaling synergizes with LRRK2 in neurons and microglia derived from human induced pluripotent stem cells

Autor: Marvin Oldrati, Daria Messelodi, Ivana Nikić-Spiegel, Maria-Jose Perez, Cong Yu, Aleksandra Arsić, Thomas Gasser, David C. Schöndorf, Vasiliki Panagiotakopoulou, Dina Ivanyuk, Meike Jakobi, Ruggiero Pio Cassatella, Silvia De Cicco, Michela Deleidi, Wadood Haq, Nicole Schneiderhan-Marra

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Nature Communications
Nature Communications 11(1), 5163 (2020). doi:10.1038/s41467-020-18755-4

Parkinson’s disease-associated kinase LRRK2 has been linked to IFN type II (IFN-γ) response in infections and to dopaminergic neuronal loss. However, whether and how LRRK2 synergizes with IFN-γ remains unclear. In this study, we employed dopamine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36ac34786697a3cff0d6b047aa772ef7
http://link.springer.com/article/10.1038/s41467-020-18755-4

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Functional and Molecular Properties of DYT-SGCE Myoclonus-Dystonia Patient-Derived Striatal Medium Spiny Neurons

Autor: Lisa Henkel, Karen Grütz, Anne Grünewald, Anna Kutschenko, Johanne Heine, Selma Staege, Andreas Hermann, Philip Seibler, Hannes Glaß, Norman Kalmbach, Florian Wegner, Thomas Gschwendtberger

Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 7
International Journal of Molecular Sciences, Vol 22, Iss 3565, p 3565 (2021)
International journal of molecular sciences 22(7), 3565 (2021). doi:10.3390/ijms22073565

Myoclonus-dystonia (DYT-SGCE, formerly DYT11) is characterized by alcohol-sensitive, myoclonic-like appearance of fast dystonic movements. It is caused by mutations in the SGCE gene encoding ε-sarcoglycan leading to a dysfunction of this transmembra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5efd60b20c5aaaf2112bf11ccfefbe65

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Developmental GABA polarity switch and neuronal plasticity in Bioengineered Neuronal Organoids

Autor: Zafeiriou, Maria-Patapia, Bao, Guobin, Hudson, James, Halder, Rashi, Blenkle, Alica, Schreiber, Marie-Kristin, Fischer, Andre, Schild, Detlev, Zimmermann, Wolfram-Hubertus

Publikováno v: Nature Communications
Nature Communications 11(1), 3791 (2020). doi:10.1038/s41467-020-17521-w
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)

Brain organoids are promising tools for disease modeling and drug development. For proper neuronal network formation excitatory and inhibitory neurons as well as glia need to co-develop. Here, we report the directed self-organization of human induced

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::ac7a12aa9624eccadf976c91dff699e9
http://europepmc.org/articles/PMC7391775

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High content organelle trafficking enables disease state profiling as powerful tool for disease modelling

Autor: Ronny Sczech, Nicole Kreiter, Julia Japtok, Andreas Hermann, Hannes Glaß, Arun Pal, Marcel Naumann

Publikováno v: Scientific data 5(1), 180241 (2018). doi:10.1038/sdata.2018.241
Scientific Data

Neurodegenerative diseases pose a complex field with various neuronal subtypes and distinct differentially affected intra-neuronal compartments. Modelling of neurodegeneration requires faithful in vitro separation of axons and dendrites, their distal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e666a102b8007dd8ec287c9a0db815a
https://doi.org/10.1038/sdata.2018.241

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Stepwise acquirement of hallmark neuropathology in FUS-ALS iPSC models depends on mutation type and neuronal aging

Autor: Albert C. Ludolph, Tobias M. Boeckers, Stefan Liebau, Moritz Klingenstein, Julia Japtok, Stefan Putz, Xenia Lojewski, Marcel Naumann, Alexander Storch, Jared Sterneckert, Peter Reinhardt, Andreas Hermann, Maria Demestre

Publikováno v: Neurobiology of Disease, Vol 82, Iss, Pp 420-429 (2015)
Neurobiology of disease 82, 420-429 (2015). doi:10.1016/j.nbd.2015.07.017

Autosomal-dominant mutations within the gene FUS (fused in sarcoma) are responsible for 5% of familial cases of amyotrophic lateral sclerosis (ALS). The FUS protein is physiologically mainly located in the nucleus, while cytoplasmic FUS aggregates ar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6df30cb25e4b5550e91a70d2f177333f
http://www.sciencedirect.com/science/article/pii/S0969996115300218

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Glycation potentiates α-synuclein-associated neurodegeneration in synucleinopathies

Publikováno v: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Agência para a Sociedade do Conhecimento (UMIC)-FCT-Sociedade da Informação
instacron:RCAAP
Brain
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
Brain 140(5), 1399-1419 (2017). doi:10.1093/brain/awx056

© The Author (2017). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved.
α-Synuclein misfolding and aggregation is a hallmark in Parkinson's disease and in several other neurodegenerative diseases kn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d50ba62720be24e704cb583505996af7

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Differentiation Efficiency of Induced Pluripotent Stem Cells Depends on the Number of Reprogramming Factors

Autor: Hans R. Schöler, Alexander Storch, Matthias Löhle, Hannes Glaß, Sigrid C. Schwarz, Jeong Beom Kim, Ursula Ravens, Andrea Kempe, Andreas Hermann, Claire Poulet, Johannes Schwarz

Publikováno v: Stem cells 30(3), 570-579 (2012). doi:10.1002/stem.1016

Reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) by retroviral overexpression of the transcription factors Oct4, Sox2, Klf4, and c-Myc holds great promise for the development of personalized cell replacement therapies. In an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d9175275598a99f03c41a610ea5cde3
https://doi.org/10.1002/stem.1016

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Synaptic inputs from stroke-injured brain to grafted human stem cell-derived neurons activated by sensory stimuli

Autor: Marita Grønning-Hansen, Ekaterina Smozhanik, Galina Skibo, Malin Parmar, Jemal Tatarishvili, Jens Schouenborg, Daniel Tornero, Olle Lindvall, Zaal Kokaia, Oliver Brüstle, Ruimin Ge, O. M. Tsupykov, Somsak Wattananit, Marcus Granmo, Shane Grealish, Cecilia Laterza, Cristina Rodríguez, Jonas Thelin

Publikováno v: Brain 140(3), aww347 (2017). doi:10.1093/brain/aww347

Transplanted neurons derived from stem cells have been proposed to improve function in animal models of human disease by various mechanisms such as neuronal replacement. However, whether the grafted neurons receive functional synaptic inputs from the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d4bad2ffae5d78ced024c88848f112f
https://doi.org/10.1093/brain/aww347

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Induced neural stem cells (iNSCs) in neurodegenerative diseases

Autor: Alexander Storch, Andreas Hermann

Publikováno v: Journal of neural transmission 120(S1), 19-25 (2013). doi:10.1007/s00702-013-1042-9

Recent advances in somatic cell reprogramming is one of the most important developments in neuroscience in the last decades since it offers for the first time the opportunity to work with disease/patient-specific neurons or other neural cell types. I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fb841c66e4587b667dbdf219d12dafc
https://pubmed.ncbi.nlm.nih.gov/23720190

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