Zobrazeno 1 - 10
of 16
pro vyhledávání: '"physiology [Exploratory Behavior]"'
Autor:
Luise Ernst, D. M. Vogt Weisenhorn, Lisa Glasl, Annemarie Zimprich, Florian Giesert, G. Piccoli, Sabine M. Hölter, Julia Zerle, Wolfgang Wurst, C. Stautner
Publikováno v:
Neurobiology of Disease, Vol 105, Iss, Pp 179-193 (2017)
Neurobiology of disease 105, 179-193 (2017). doi:10.1016/j.nbd.2017.05.013
Neurobiology of disease 105, 179-193 (2017). doi:10.1016/j.nbd.2017.05.013
The aim of the present study was to further explore the in vivo function of the Leucine-rich repeat kinase 2 (LRRK2)-gene, which is mutated in certain familial forms of Parkinson's disease (PD). We generated a mouse model harboring the disease-associ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5d68f95eb6c4cce08851f130b9bb243
http://www.sciencedirect.com/science/article/pii/S0969996117301237
http://www.sciencedirect.com/science/article/pii/S0969996117301237
Publikováno v:
Neurobiology of learning and memory 130, 34-43 (2016). doi:10.1016/j.nlm.2016.01.007
Frontotemporal lobar degeneration (FTLD) is a neurodegenerative disorder, a major subset of which is characterized by the accumulation of abnormal forms of the protein tau, leading to impairments in motor functions as well as language and behavioral
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::639930ef5a30c321c356f4ce3d3f71f2
https://doi.org/10.1016/j.nlm.2016.01.007
https://doi.org/10.1016/j.nlm.2016.01.007
Publikováno v:
Behavioural processes 157, 711-716 (2018). doi:10.1016/j.beproc.2017.11.009
Despite its wide application in studies on memory and disease-related cognitive impairment, the use of the novel object recognition (NOR) test in research on aging has been limited and produced conflicting results. The purpose of this study was to ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89e3875094d0375d7d72cb06d567af67
Publikováno v:
eLife, Vol 6 (2017)
Recercat. Dipósit de la Recerca de Catalunya
instname
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
eLife
Recercat. Dipósit de la Recerca de Catalunya
instname
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
eLife
Animals explore their environment to encounter suitable food resources. Despite its vital importance, this behavior puts individuals at risk by consuming limited internal energy during locomotion. We have developed a novel assay to investigate how fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bfc95ac9c86dd83e1a7866001261c79
https://escholarship.org/uc/item/4v07h5zr
https://escholarship.org/uc/item/4v07h5zr
Publikováno v:
Behavioural brain research 332, 316-326 (2017). doi:10.1016/j.bbr.2017.06.013
Schizophrenia is a chronic and devastating disease with an overall lifetime risk of 1%. While positive symptoms of schizophrenia such as hallucinations and delusions are reduced by antipsychotic medication based on the inhibition of type 2 dopaminerg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d08b39ab5a8168a38ad1f1dcf50b120
https://pubmed.ncbi.nlm.nih.gov/28634108
https://pubmed.ncbi.nlm.nih.gov/28634108
Autor:
Hans-Christian Pape, Michael T. Heneka, Thea Hammerschmidt, Markus P. Kummer, Ana Martinez, David Weinshenker, Dick Terwel, Monika Stoll, Jason P. Schroeder, Joachim L. Schultze, Ali Gorji, Karen S. Rommelfanger
Publikováno v:
Biological psychiatry 73(5), 454-463 (2013). doi:10.1016/j.biopsych.2012.06.013
Biological Psychiatry
Biological Psychiatry
Background Degeneration of the locus coeruleus (LC), the major noradrenergic nucleus in the brain, occurs early and is ubiquitous in Alzheimer's disease (AD). Experimental lesions to the LC exacerbate AD-like neuropathology and cognitive deficits in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1706cbc64b37044bd4395b595f540e2a
https://doi.org/10.1016/j.biopsych.2012.06.013
https://doi.org/10.1016/j.biopsych.2012.06.013
Autor:
Li, Shijia, Demenescu, Liliana Ramona, Sweeney-Reed, Catherine M, Krause, Anna Linda, Metzger, Coraline D, Walter, Martin
Publikováno v:
Frontiers in Psychology
Hum Brain Mapp
Human brain mapping 38(8), 4064-4077 (2017). doi:10.1002/hbm.23648
Hum Brain Mapp
Human brain mapping 38(8), 4064-4077 (2017). doi:10.1002/hbm.23648
A salience network (SN) anchored in the anterior insula (AI) and dorsal anterior cingulate cortex (dACC) plays a key role in switching between brain networks during salience detection and attention regulation. Previous fMRI studies have associated ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::da3b63bfa73cb5269ffc50a77815418f
https://pubmed.ncbi.nlm.nih.gov/29535669
https://pubmed.ncbi.nlm.nih.gov/29535669
Autor:
Sabine M, Hölter, Jan, Einicke, Bettina, Sperling, Annemarie, Zimprich, Lillian, Garrett, Helmut, Fuchs, Valerie, Gailus-Durner, Martin, Hrabé de Angelis, Wolfgang, Wurst
Publikováno v:
Current protocols in mouse biology 5(4), 291-309 (2015). doi:10.1002/9780470942390.mo150010
Phenotyping of inbred mouse strains and genetically modified mouse models for characteristics related to neuropsychiatric diseases includes assessing their anxiety-related behavior. A variety of tests have been developed to measure anxiety in laborat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::4700d1326622ab37847aae359595ebf0
https://pub.dzne.de/record/141150
https://pub.dzne.de/record/141150
Publikováno v:
Physiology & behavior 135, 25-33 (2014). doi:10.1016/j.physbeh.2014.05.041
Transgenic animal models of Alzheimer's disease (AD) are widely used to investigate mechanisms of pathophysiology and cognitive dysfunctions. A model with a very early development of parenchymal plaque load at the age of 2months is the 5xFAD mouse (T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bdf7bf6640b64d70b05048b7187291b
https://pubmed.ncbi.nlm.nih.gov/24907698
https://pubmed.ncbi.nlm.nih.gov/24907698
Autor:
Julia Calzada-Wack, Eckhard Wolf, Ilona Mossbrugger, Leticia Quintanilla-Fend, Steven J. Romney, Sabine M. Hölter, Elizabeth A. Leibold, Martin Hrabě de Angelis, Thomas Klopstock, Ildiko Racz, Andreas Zimmer, Lillian Garrett, Lore Becker, Helmut Fuchs, Valerie Gailus-Durner, Kimberly B. Zumbrennen-Bullough, Birgit Rathkolb, Wolfgang Wurst
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e98072 (2014)
PLOS ONE 9(6), e98072 (2014). doi:10.1371/journal.pone.0098072
PLoS ONE
PLoS ONE 9:e98072 (2014)
PLOS ONE
PLOS ONE 9(6), e98072 (2014). doi:10.1371/journal.pone.0098072
PLoS ONE
PLoS ONE 9:e98072 (2014)
PLOS ONE
Iron Regulatory Protein 2 (Irp2, Ireb2) is a central regulator of cellular iron homeostasis in vertebrates. Two global knockout mouse models have been generated to explore the role of Irp2 in regulating iron metabolism. While both mouse models show t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::935c2cc30d947d2695fc9d9ce9dc56ca
http://europepmc.org/articles/PMC4045679?pdf=render
http://europepmc.org/articles/PMC4045679?pdf=render