α-synuclein interacts with PrPC to induce cognitive impairment through mGluR5 and NMDAR2B

Autor: Joana E. Coelho, Tiago F. Outeiro, Mariana Temido-Ferreira, Inga Zerr, Jeong-Seop Rhee, Matthias Schmitz, Éva M. Szegö, Sandra H. Vaz, Diana G. Ferreira, Vânia L. Batalha, Hugo Vicente Miranda, Luísa V. Lopes, Inês Marques-Morgado

Publikováno v: Nature reviews / Neuroscience 20(11), 1569-1579 (2017). doi:10.1038/nn.4648
Nature Neuroscience

© 2017 Nature America, Inc., part of Springer Nature. All rights reserved.
Synucleinopathies, such as Parkinson's disease and dementia with Lewy bodies, are neurodegenerative disorders that are characterized by the accumulation of α-synuclein

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::100a137a74503d7ee4176a5166446ddb
https://doi.org/10.1038/nn.4648

Involvement of Mossy Cells in Sharp Wave-Ripple Activity In Vitro

Autor: Dietmar Schmitz, Aarti Swaminathan, Ines Wichert, Nikolaus Maier

Publikováno v: Cell reports 23(9), 2541-2549 (2018). doi:10.1016/j.celrep.2018.04.095
Cell Reports, Vol 23, Iss 9, Pp 2541-2549 (2018)

The role of mossy cells (MCs) of the hippocampal dentate area has long remained mysterious. Recent research has begun to unveil their significance in spatial computation of the hippocampus. Here, we used an in vitro model of sharp wave-ripple complex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e94712f2b260cb20dc3e427692a203f
https://pubmed.ncbi.nlm.nih.gov/29847786

Coexpressed Auxiliary Subunits Exhibit Distinct Modulatory Profiles on AMPA Receptor Function

Autor: Alexandru Rusu, Ling Zhang, Jakob von Engelhardt, Paul Farrow, Anton Schulmann, Konstantin Khodosevich, Eric Jacobi, Rolf Sprengel, Hannah Monyer

Publikováno v: Neuron 83(3), 601-615 (2014). doi:10.1016/j.neuron.2014.07.004
Neuron

Summary Gating properties and surface trafficking of AMPA receptors (AMPARs) are modulated by auxiliary subunits. Here we studied the function of coexpressed auxiliary subunits belonging to two different classes. We focused on TARP γ-8 and CKAMP44 i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e5e830fde15fc966272f663b9f31f4c

Ambient Glutamate Promotes Paroxysmal Hyperactivity in Cortical Pyramidal Neurons at Amyloid Plaques via Presynaptic mGluR1 Receptors

Autor: Eva Ferreira Rodrigues, Jochen Herms, Saak V. Ovsepian, Susana Valero Freitag, Lidia Blazquez-Llorca

Publikováno v: Cerebral cortex 27(10), cercor;bhw267v1 (2016). doi:10.1093/cercor/bhw267

Synaptic dysfunctions and altered neuronal activity play major role in the pathophysiology of Alzheimer's disease (AD), with underlying mechanisms largely unknown. We report that in the prefrontal cortex of amyloid precursor protein-presenilin 1 and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77d8eeca1ae4445f2fda0b5f8b24d5e7
https://doi.org/10.1093/cercor/bhw267

Cav2-Type Calcium Channels Encoded bycacRegulate AP-Independent Neurotransmitter Release at Cholinergic Synapses in AdultDrosophilaBrain

Autor: Xicui Sun, Huaiyu Gu, Jorge Iniguez, Jorge M. Campusano, Hailing Su, Andy An Hoang, Shaojuan Amy Jiang, Monica Lavian, Diane K. O'Dowd

Publikováno v: Gu, Huaiyu; Jiang, Shaojuan Amy; Campusano, Jorge M; Iniguez, Jorge; Su, Hailing; Hoang, Andy An; et al.(2009). Cav2-type calcium channels encoded by cac regulate AP-independent neurotransmitter release at cholinergic synapses in adult Drosophila brain.. Journal of neurophysiology, 101(1), 42-453. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/97t4v64t

Voltage-gated calcium channels containing α1 subunits encoded by Cav2 family genes are critical in regulating release of neurotransmitter at chemical synapses. In Drosophila, cac is the only Cav2-type gene. Cacophony (CAC) channels are localized in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ba7007745dfabf371fdad005548460d
https://doi.org/10.1152/jn.91103.2008