Výsledky vyhledávání - "physiology [Drosophila melanogaster]"

The anterior paired lateral neuron normalizes odour-evoked activity in the Drosophila mushroom body calyx

Autor: Luigi Prisco, Stephan Hubertus Deimel, Hanna Yeliseyeva, André Fiala, Gaia Tavosanis

Publikováno v: eLife 10, e74172 (2021). doi:10.7554/eLife.74172
eLife, Vol 10 (2021)

To identify and memorize discrete but similar environmental inputs, the brain needs to distinguish between subtle differences of activity patterns in defined neuronal populations. The Kenyon cells (KCs) of the Drosophila adult mushroom body (MB) resp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a81b48aa5afd22d50f926184db39728
https://doi.org/10.7554/elife.74172

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Circuit reorganization in the Drosophila mushroom body calyx accompanies memory consolidation

Autor: Philipp Ranft, Gaia Tavosanis, J. Scott Lauritzen, Lothar Baltruschat, André Fiala, Davi D. Bock, Luigi Prisco

Publikováno v: Cell Rep
Cell reports 34(11), 108871-(2021). doi:10.1016/j.celrep.2021.108871

The formation and consolidation of memories are complex phenomena involving synaptic plasticity, microcircuit reorganization, and the formation of multiple representations within distinct circuits. To gain insight into the structural aspects of memor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad68944dcbe50a4fd6f766fc98c5473e
https://europepmc.org/articles/PMC8515896/

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The NAD+ Precursor Nicotinamide Riboside Rescues Mitochondrial Defects and Neuronal Loss in iPSC and Fly Models of Parkinson’s Disease

Autor: Sigrun Nestel, Silvia De Cicco, Vasiliki Panagiotakopoulou, Cong Yu, David C. Schöndorf, Michela Deleidi, Lukas Kristoffer Schwarz, Ivana Giunta, Oliver Bandmann, Thomas Gasser, Bernd Heimrich, Pascale Baden, Jan Pruszak, Gabriele Di Napoli, Marcus Keatinge, Alexander J. Whitworth, Alvaro Sanchez-Martinez, Dina Ivanyuk

Publikováno v: Cell reports 23(10), 2976-2988 (2018). doi:10.1016/j.celrep.2018.05.009

While mitochondrial dysfunction is emerging as key in Parkinson's disease (PD), a central question remains whether mitochondria are actual disease drivers and whether boosting mitochondrial biogenesis and function ameliorates pathology. We address th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23332f701e589a7a2b4f378a16eaf621
https://doi.org/10.1016/j.celrep.2018.05.009

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GDAP2 mutations implicate susceptibility to cellular stress in a new form of cerebellar ataxia

Autor: Lisa van Ninhuijs, Jean Jacques Martin, Jonathan Baets, Annette Schenck, Erik-Jan Kamsteeg, Bart P.C. van de Warrenburg, Tine Deconinck, Rebecca Schüle, Stephan Züchner, Ilse Eidhof, Peter De Jonghe

Publikováno v: Brain
Brain, 141, 9, pp. 2592-2604
Brain, 141, 2592-2604
Brain 141(9), 2592-2604 (2018). doi:10.1093/brain/awy198

Eidhofet al. report a new subtype of autosomal recessive cerebellar ataxia caused by mutations inGDAP2, and show thatGdap2 knockdown inDrosophila recapitulates locomotor dysfunction and shortened lifespan. Susceptibility to cellular stress in theGdap

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dec1f10d731474e399aef06d6c71527
https://hdl.handle.net/10067/1547910151162165141

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The de-ubiquitylating enzyme DUBA is essential for spermatogenesis in Drosophila

Autor: Eli Arama, Timo Glatter, Meike Broemer, Juliane Melzer, Eva Aguado Roca, Lisa Koerver, Dominic Teichert

Publikováno v: Cell death and differentiation 23(12), 2019-2030 (2016). doi:10.1038/cdd.2016.79

De-ubiquitylating enzymes (DUBs) reverse protein ubiquitylation and thereby control essential cellular functions. Screening for a DUB that counteracts caspase ubiquitylation to regulate cell survival, we identified the Drosophila ovarian tumour-type

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::803440b53f89b9fce2f07f5337b468e0
https://pub.dzne.de/record/138902

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TDP-43-mediated neuron loss in vivo requires RNA-binding activity

Autor: David Herholz, Peter Karsten, Philipp J. Kahle, Kavita Kaur, Daniel J. Müller, Till Marquardt, Stephanie Weber, Aaron Voigt, Jörg B. Schulz, Fabienne C. Fiesel

Publikováno v: PLoS ONE, Vol 5, Iss 8, p e12247 (2010)
PLOS ONE 5(8), e12247 (2010). doi:10.1371/journal.pone.0012247
PLoS ONE

Alteration and/or mutations of the ribonucleoprotein TDP-43 have been firmly linked to human neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). The relative impacts of TDP-43 altera

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8d9831a55eb15adebbb1a2c30dac84f
http://europepmc.org/articles/PMC2923622?pdf=render

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Cellular bases of behavioral plasticity: establishing and modifying synaptic circuits in the Drosophila genetic system

Autor: Richard A. Baines, Kendal Broadie, Jeffrey Rohrbough, Diane K. O'Dowd

Publikováno v: Rohrbough, Jeffrey; O'Dowd, Diane K; Baines, Richard A; & Broadie, Kendal. (2003). Cellular bases of behavioral plasticity: establishing and modifying synaptic circuits in the Drosophila genetic system.. Journal of neurobiology, 54(1), 254-271. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/4rk4k0w6

Genetic malleability and amenability to behavioral assays make Drosophila an attractive model for dissecting the molecular mechanisms of complex behaviors, such as learning and memory. At a cellular level, Drosophila has contributed a wealth of infor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dd0253b404644e1671daec191f7069f
http://www.escholarship.org/uc/item/4rk4k0w6

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