Výsledky vyhledávání - "physiology [Axonal Transport]"

High content organelle trafficking enables disease state profiling as powerful tool for disease modelling

Autor: Ronny Sczech, Nicole Kreiter, Julia Japtok, Andreas Hermann, Hannes Glaß, Arun Pal, Marcel Naumann

Publikováno v: Scientific data 5(1), 180241 (2018). doi:10.1038/sdata.2018.241
Scientific Data

Neurodegenerative diseases pose a complex field with various neuronal subtypes and distinct differentially affected intra-neuronal compartments. Modelling of neurodegeneration requires faithful in vitro separation of axons and dendrites, their distal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e666a102b8007dd8ec287c9a0db815a
https://doi.org/10.1038/sdata.2018.241

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Internalization and retrograde axonal trafficking of tetanus toxin in motor neurons and trans-synaptic propagation at central synapses exceed those of its C-terminal-binding fragments

Autor: Ovsepian, Saak V, Ovespian, Saak V, Bodeker, MacDara, O'Leary, Valerie B, Lawrence, Gary W, Oliver Dolly, J.

Publikováno v: Brain structure & function 220(3), 1825-1838 (2015). doi:10.1007/s00429-015-1004-0

The prominent tropism of tetanus toxin (TeTx) towards peripheral nerves with retrograde transport and transfer to central neurons render it an invaluable probe for exploring fundamental neuronal processes such as endocytosis, retrograde trafficking a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38b43cca9a3498b5543e5f0dded563bb
https://pub.dzne.de/record/137904

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CNS axons globally increase axonal transport after peripheral conditioning

Autor: Mónica Mendes Sousa, Inês S. Rodrigo, Sergio Roberto de Andrade Leite, Thomas Misgeld, Carla Teixeira, Fernando M. Mar, Marlene M. Morgado, Anabel R. Simões, Telma Emanuela Santos

Publikováno v: The journal of neuroscience 34(17), 5965-5970 (2014). doi:10.1523/JNEUROSCI.4680-13.2014

Despite the inability of CNS axons to regenerate, an increased regenerative capacity can be elicited following conditioning lesion to the peripheral branch of dorsal root ganglia neurons (DRGs). Byin vivoradiolabeling of rat DRGs, coupled to mass spe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7e4a3fcb53452f6177d61ed9b3b5cbf
https://pub.dzne.de/record/137365

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Spastic paraplegia mutation N256S in the neuronal microtubule motor KIF5A disrupts axonal transport in a Drosophila HSP model

Autor: Petra Füger, Kathrin N. Karle, Doychin T. Stanchev, Carola D. Schneider, Matthias Flötenmeyer, Jeannine V. Kern, Vrinda Sreekumar, Katharina J. Daub, Vera K. Siegert, Rebecca Schüle, Tobias M. Rasse, Ludger Schöls, Heinz Schwarz

Publikováno v: PLoS Genetics
PLoS Genetics, Vol 8, Iss 11, p e1003066 (2012)
PLoS Genetics 8(11), e1003066 (2012). doi:10.1371/journal.pgen.1003066

Hereditary spastic paraplegias (HSPs) comprise a group of genetically heterogeneous neurodegenerative disorders characterized by spastic weakness of the lower extremities. We have generated a Drosophila model for HSP type 10 (SPG10), caused by mutati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e98242ad78e8afd6297ab0e2066f6ad
https://pubmed.ncbi.nlm.nih.gov/23209432

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Novel diffusion barrier for axonal retention of Tau in neurons and its failure in neurodegeneration

Autor: Li, X., Kumar, Y., Zempel, H., Mandelkow, E., Biernat, J.

Publikováno v: The EMBO journal 30(23), 4825-4837 (2011). doi:10.1038/emboj.2011.376
Embo Journal

Missorting of Tau from axons to the somatodendritic compartment of neurons is a hallmark of Alzheimer's disease, but the mechanisms underlying normal sorting and pathological failure are poorly understood. Here, we used several Tau constructs labelle

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::deceb107b2b31e094a017fa7d727e5a0
https://pub.dzne.de/record/136362

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Pervasive Axonal Transport Deficits in Multiple Sclerosis Models

Autor: Florence M. Bareyre, Ronald Naumann, Catherine D. Sorbara, Thomas Misgeld, Ivana Nikić, Anne Ladwig, Doron Merkler, Derron L. Bishop, Martin Kerschensteiner, Leanne Godinho, Petar Marinković, Tatjana Kleele, Naomi Elizabeth Wagner

Publikováno v: Europe PubMed Central
Neuron, Vol. 84, No 6 (2014) pp. 1183-1190
Neuron 84(6), 1183-1190 (2014). doi:10.1016/j.neuron.2014.11.006
Neuron

SummaryImpaired axonal transport can contribute to axon degeneration and has been described in many neurodegenerative diseases. Multiple sclerosis (MS) is a common neuroinflammatory disease, which is characterized by progressive axon degeneration—w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf425848fcb4abcfda10f92b12231c17

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