Zobrazeno 1 - 4
of 4
pro vyhledávání: '"physiology [Aspartic Acid Endopeptidases]"'
Autor:
Matthew E. Kennedy, Peer-Hendrik Kuhn, Stefan F. Lichtenthaler, Philip C. Wong, Robert Vassar, Lawrence Rajendran, Christian Haass
Publikováno v:
Journal of neurochemistry 130(1), 4-28 (2014). doi:10.1111/jnc.12715
Journal of Neurochemistry
Journal of Neurochemistry
The β-site APP cleaving enzymes 1 and 2 (BACE1 and BACE2) were initially identified as transmembrane aspartyl proteases cleaving the amyloid precursor protein (APP). BACE1 is a major drug target for Alzheimer's disease because BACE1-mediated cleavag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dd3bb70aae49c27c50e99eccfa8922a
https://doi.org/10.1111/jnc.12715
https://doi.org/10.1111/jnc.12715
Autor:
Sabina Tahirovic, Annika Wulf-Goldenberg, Christian Haass, Cyril Cheret, Paul Saftig, Florence R. Fricker, Alistair N. Garratt, Carmen Birchmeier, Hagen Wende, Michael Willem, Klaus-Armin Nave, David L.H. Bennett
Publikováno v:
The EMBO Journal
The EMBO journal 32(14), 2015-2028 (2013). doi:10.1038/emboj.2013.146
The EMBO journal 32(14), 2015-2028 (2013). doi:10.1038/emboj.2013.146
The protease β-secretase 1 (Bace1) was identified through its critical role in production of amyloid-β peptides (Aβ), the major component of amyloid plaques in Alzheimer's disease. Bace1 is considered a promising target for the treatment of this p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eacd5357a8fcb5c20b9ee2cb77c09aaf
https://hdl.handle.net/21.11116/0000-000D-3620-211858/00-001M-0000-0029-26BC-9
https://hdl.handle.net/21.11116/0000-000D-3620-211858/00-001M-0000-0029-26BC-9
Autor:
Viktorija Velanac, Tobias M. Fischer, Wilko Hinrichs, Veronica Brivio, Maike N. Gummert, Klaus-Armin Nave, Amelia Trimarco, Wiebke Möbius, Tilmann Unterbarnscheidt, Carla Taveggia, Moritz J. Rossner, Markus H. Schwab, Christian Haass, Michael Willem
Publikováno v:
Glia
Glia; Vol 60
Glia 60(2), 203-217 (2011). doi:10.1002/glia.21255
Glia; Vol 60
Glia 60(2), 203-217 (2011). doi:10.1002/glia.21255
Myelin sheath thickness is precisely adjusted to axon caliber, and in the peripheral nervous system, neuregulin 1 (NRG1) type III is a key regulator of this process. It has been proposed that the protease BACE1 activates NRG1 dependent myelination. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c826df07eb95041e13d2438451d9846e
https://hdl.handle.net/11858/00-001M-0000-002A-4BB0-C11858/00-001M-0000-002A-4BAE-3
https://hdl.handle.net/11858/00-001M-0000-002A-4BB0-C11858/00-001M-0000-002A-4BAE-3
Publikováno v:
Journal of neurochemistry 117(5), 779-796 (2011). doi:10.1111/j.1471-4159.2011.07248.x
Regulated intramembrane proteolysis (RIP) controls the communication between cells and the extracellular environment. RIP is essential in the nervous system, but also in other tissues. In the RIP process, a membrane protein typically undergoes two co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::d55ca21c059b9a288e1fee22e01211e0
https://pub.dzne.de/record/136223
https://pub.dzne.de/record/136223