Zobrazeno 1 - 10
of 403
pro vyhledávání: '"physiologically based pharmacokinetic (PBPK) modeling"'
Publikováno v:
Biomedicines, Vol 12, Iss 9, p 1974 (2024)
In this study, a physiologically based pharmacokinetic (PBPK) modeling framework was employed to explore infliximab exposure following intravenous (5 mg/kg) and subcutaneous administration (encompassing the approved 120 mg flat-fixed dose as a switch
Externí odkaz:
https://doaj.org/article/3ecb3f87b70f44dfab33b11f69b20dbf
Autor:
Xuefen Yin, Brian Cicali, Leyanis Rodriguez-Vera, Viera Lukacova, Rodrigo Cristofoletti, Stephan Schmidt
Publikováno v:
Pharmaceutics, Vol 16, Iss 6, p 737 (2024)
Carbamazepine (CBZ) is commonly prescribed for epilepsy and frequently used in polypharmacy. However, concerns arise regarding its ability to induce the metabolism of other drugs, including itself, potentially leading to the undertreatment of co-admi
Externí odkaz:
https://doaj.org/article/aa09ac29b3c6427e9fd2dfccb09dc310
Akademický článek
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Akademický článek
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Autor:
Wei-Chun Chou, Yi-Hsien Cheng, Jim E. Riviere, Nancy A. Monteiro-Riviere, Wolfgang G. Kreyling, Zhoumeng Lin
Publikováno v:
Particle and Fibre Toxicology, Vol 19, Iss 1, Pp 1-19 (2022)
Abstract Background Physiologically based pharmacokinetic (PBPK) modeling is an important tool in predicting target organ dosimetry and risk assessment of nanoparticles (NPs). The methodology of building a multi-route PBPK model for NPs has not been
Externí odkaz:
https://doaj.org/article/aa10cf438b8d48268b72ca7a3f8e47b2
Autor:
Cindy Hoi Ting Yeung, Sherilyn K. D. Houle, Philip O. Anderson, Brookie M. Best, Samuel Dubinsky, Andrea N. Edginton
Publikováno v:
Frontiers in Pediatrics, Vol 11 (2023)
IntroductionBreastfeeding has major benefits to the maternal-infant dyad and yet healthcare providers have expressed uncertainty about advocating breastfeeding when mothers are taking medications. The tendency for some providers to be more cautious i
Externí odkaz:
https://doaj.org/article/55e66c1ed5064b06be3c08a7ac818841
Publikováno v:
Pharmaceutics, Vol 15, Iss 11, p 2624 (2023)
The purpose of this literature review is to comprehensively summarize changes in the expression of phase II drug-metabolizing enzymes and drug transporters in both the pregnant woman and the placenta. Using PubMed®, a systematic search was conducted
Externí odkaz:
https://doaj.org/article/a96c35c23eea4e178c7fec153ecf8106
Autor:
Chuanhai Li, Lidan Jiang, Donghui Zhang, Yuan Qi, Xinyi Wang, Yuan Jin, Xinya Liu, Yongfeng Lin, Jiao Luo, Lin Xu, Kunming Zhao, Dianke Yu
Publikováno v:
Environment International, Vol 173, Iss , Pp 107846- (2023)
Human health risk assessment of chemicals is essential but often relies on time-consuming and animal and labor-extensive procedures. Here, we develop a population-based, quantitative in vitro to in vivo extrapolation (QIVIVE) approach which depended
Externí odkaz:
https://doaj.org/article/e0521b04ef6548dea8f0991d41a79897
Akademický článek
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Autor:
Weize Huang, Felix Stader, Phyllis Chan, Colby S. Shemesh, Yuan Chen, Katherine L. Gill, Hannah M. Jones, Linzhong Li, Gianluca Rossato, Benjamin Wu, Jin Y. Jin, Pascal Chanu
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Background: Atezolizumab has been studied in multiple indications for both pediatric and adult patient populations. Generally, clinical studies enrolling pediatric patients may not collect sufficient pharmacokinetic data to characterize the drug expo
Externí odkaz:
https://doaj.org/article/3faa387e1cec491bb32e60f6076ebfaa