Zobrazeno 1 - 10
of 917
pro vyhledávání: '"physiologically based pharmacokinetic (PBPK)"'
Autor:
Furun Wang, Liuhan Dong, Juanwen Hu, Shijie Yang, Lingchao Wang, Zhiwei Zhang, Wenpeng Zhang, Xiaomei Zhuang
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Tetrandrine (TET) has been traditionally used in China as a medication to treat silicosis and has recently demonstrated anti-SARS-CoV-2 potential in vitro. By recognizing the disparity between in vitro findings and in vivo performance, we aimed to es
Externí odkaz:
https://doaj.org/article/c59bab6b641c4d9e84c5550f8d83fd36
Publikováno v:
Biomedicines, Vol 12, Iss 9, p 1974 (2024)
In this study, a physiologically based pharmacokinetic (PBPK) modeling framework was employed to explore infliximab exposure following intravenous (5 mg/kg) and subcutaneous administration (encompassing the approved 120 mg flat-fixed dose as a switch
Externí odkaz:
https://doaj.org/article/3ecb3f87b70f44dfab33b11f69b20dbf
Autor:
Marjory Moreau, Liam Simms, Melvin E. Andersen, Edgar Trelles Sticken, Roman Wieczorek, Sarah Jean Pour, Fiona Chapman, Karin Roewer, Sandra Otte, Jeffrey Fisher, Matthew Stevenson
Publikováno v:
Frontiers in Toxicology, Vol 6 (2024)
With the use of in vitro new approach methodologies (NAMs) for the assessment of non-combustible next-generation nicotine delivery products, new extrapolation methods will also be required to interpret and contextualize the physiological relevance of
Externí odkaz:
https://doaj.org/article/06e7c45c8815464bb61eca7e8d431b5c
Autor:
Chi-Yun Chen, Zhoumeng Lin
Publikováno v:
Environment International, Vol 186, Iss , Pp 108617- (2024)
Microplastics (MPs) and nanoplastics (NPs) pollution has emerged as a significant and widespread environmental issue. Humans are inevitably exposed to MPs and NPs via ingestion, inhalation, and dermal contacts from various sources. However, mechanist
Externí odkaz:
https://doaj.org/article/f7b491913b974d6e9cd44b4c7c031033
Autor:
Xuefen Yin, Brian Cicali, Leyanis Rodriguez-Vera, Viera Lukacova, Rodrigo Cristofoletti, Stephan Schmidt
Publikováno v:
Pharmaceutics, Vol 16, Iss 6, p 737 (2024)
Carbamazepine (CBZ) is commonly prescribed for epilepsy and frequently used in polypharmacy. However, concerns arise regarding its ability to induce the metabolism of other drugs, including itself, potentially leading to the undertreatment of co-admi
Externí odkaz:
https://doaj.org/article/aa09ac29b3c6427e9fd2dfccb09dc310
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Tirzepatide is an emerging hypoglycemic agent that has been increasing used in adults, yet its pharmacokinetic (PK) behavior and dosing regimen in pediatric population remain unclear. This study aimed to employ the physiologically based pharmacokinet
Externí odkaz:
https://doaj.org/article/013ec681a4734a3c8ebd813398a34070
Publikováno v:
Pharmacology Research & Perspectives, Vol 11, Iss 4, Pp n/a-n/a (2023)
Abstract We aimed to use physiologically based pharmacokinetic (PBPK) modeling and simulation to predict imatinib steady‐state plasma exposure in patients with chronic myeloid leukemia (CML) to investigate variability in outcomes. A validated imati
Externí odkaz:
https://doaj.org/article/639c704b3e3a43ecaec0d443cd48baa2
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/5eaf078e5e1c47b6b7edddf00ba8fa01
Autor:
Xinxin Yang, Manuela Grimstein, Michelle Pressly, Elimika Pfuma Fletcher, Stacy Shord, Ruby Leong
Publikováno v:
Pharmaceutics, Vol 15, Iss 12, p 2727 (2023)
Background: The treatment of cancer during pregnancy remains challenging with knowledge gaps in drug dosage, safety, and efficacy due to the under-representation of this population in clinical trials. Our aim was to investigate physiological changes
Externí odkaz:
https://doaj.org/article/c089f42c072c40c3a6e8aab323e228ae
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