Zobrazeno 1 - 10
of 6 240
pro vyhledávání: '"physiologically based pharmacokinetic"'
Autor:
Nada Abla, Anne Claire Marrast, Elodie Jambert, Naomi Richardson, Stephan Duparc, Lisa Almond, Karen Rowland Yeo, Xian Pan, Joel Tarning, Ping Zhao, Janice Culpepper, Catriona Waitt, Charlotte Koldeweij, Susan Cole, Andrew S. Butler, Sonia Khier, Jörg J. Möhrle, Myriam El Gaaloul
Publikováno v:
Malaria Journal, Vol 23, Iss 1, Pp 1-12 (2024)
Abstract Plasmodium vivax malaria remains a global health challenge, with approximately 6.9 million estimated cases in 2022. The parasite has a dormant liver stage, the hypnozoite, which reactivates to cause repeated relapses over weeks, months, or y
Externí odkaz:
https://doaj.org/article/45b60ab3d99845c694b1be738e16f7c1
Autor:
Lin Zijin, Liu Xiaodong
Publikováno v:
Guoji Yanke Zazhi, Vol 24, Iss 9, Pp 1408-1415 (2024)
Vision is closely tied to quality of life. Traditional drug delivery routes for clinical therapy of key ocular diseases, such as glaucoma, are topical and systemic administrations, which are less invasive but often face some physiological barriers su
Externí odkaz:
https://doaj.org/article/6e63fe7514564999804d4b1e97a36d9b
Publikováno v:
Frontiers in Veterinary Science, Vol 11 (2024)
Externí odkaz:
https://doaj.org/article/4e844b850dce43b7add98d9e1898ffc9
Autor:
Takumi Maruyama, Hidefumi Kasai, Yutaka Fukaya, Mitsuru Shiokawa, Toshimi Kimura, Yukihiro Hamada
Publikováno v:
Frontiers in Microbiology, Vol 15 (2024)
Letermovir (LET) is a novel antiviral agent recently approved for cytomegalovirus (CMV) prophylaxis of renal transplant patients in Japan. However, its interactions with tacrolimus (TAC), an important immunosuppressant, remain ambiguous, warranting c
Externí odkaz:
https://doaj.org/article/8f157bb039a14f76bfc16141420e7b59
Autor:
Mengyuan Wu, Kun Feng, Xiao Wu, Chang Liu, Shixing Zhu, Frederico S. Martins, Mingming Yu, Zhihua Lv, Meixing Yan, Sherwin K. B. Sy
Publikováno v:
Frontiers in Microbiology, Vol 15 (2024)
BackgroundThe combination antimicrobial therapy consisting of amikacin, polymyxin-B, and sulbactam demonstrated in vitro synergy against multi-drug resistant Acinetobacter baumannii.ObjectivesThe objectives were to predict drug disposition and extrap
Externí odkaz:
https://doaj.org/article/a444d15486d747eea075316b80276b61
Publikováno v:
Frontiers in Veterinary Science, Vol 11 (2024)
Physiologically Based Pharmacokinetic (PBPK) models can provide forecasts of the drug residues within the organism. Ractopamine (RAC) is a typical β-agonist. In this study, we developed a PBPK model for RAC in goats. The goal was to predict the dist
Externí odkaz:
https://doaj.org/article/f7a730e9aed144e6900cf85902f677fd
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
IntroductionAnimal models play a vital role in pharmaceutical research and development by supporting the planning and design of later clinical studies. To improve confidence and reliability of first in human dose estimates it is essential to assess t
Externí odkaz:
https://doaj.org/article/584054ca9bd24dc6b481a8570bbae847
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
BackgroundParkinson’s disease psychosis (PDP) is a common and distressing complication of Parkinson’s disease (PD), characterized by hallucinations and delusions. This research aimed to assess the pharmacokinetics and safety of NH130, a selective
Externí odkaz:
https://doaj.org/article/27cf86ff44954fdeb3d0f5edf77681e3
Autor:
Furun Wang, Liuhan Dong, Juanwen Hu, Shijie Yang, Lingchao Wang, Zhiwei Zhang, Wenpeng Zhang, Xiaomei Zhuang
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Tetrandrine (TET) has been traditionally used in China as a medication to treat silicosis and has recently demonstrated anti-SARS-CoV-2 potential in vitro. By recognizing the disparity between in vitro findings and in vivo performance, we aimed to es
Externí odkaz:
https://doaj.org/article/c59bab6b641c4d9e84c5550f8d83fd36
Autor:
Joyce E. M. van der Heijden, Marika de Hoop-Sommen, Noa Hoevenaars, Jolien J. M. Freriksen, Koen Joosten, Rick Greupink, Saskia N. de Wildt
Publikováno v:
Frontiers in Pediatrics, Vol 12 (2024)
IntroductionCritically ill patients show large variability in drug disposition due to e.g., age, size, disease and treatment modalities. Physiologically-based pharmacokinetic (PBPK) models can be used to design individualized dosing regimens taking t
Externí odkaz:
https://doaj.org/article/171193c1949d4eec9eea2f643a4373e1