Zobrazeno 1 - 10
of 990
pro vyhledávání: '"physiologically–based pharmacokinetic model"'
Publikováno v:
Shanghai Jiaotong Daxue xuebao. Yixue ban, Vol 44, Iss 11, Pp 1414-1421 (2024)
Objective·To develop physiologically based pharmacokinetic (PBPK) models specifically designed for the Chinese population by utilizing the combination of clozapine and fluvoxamine as a case, and predict the drug-drug interaction (DDI) associated wit
Externí odkaz:
https://doaj.org/article/bcdc794bf43f4f2ca547c7d07e3423db
Autor:
Lin Zijin, Liu Xiaodong
Publikováno v:
Guoji Yanke Zazhi, Vol 24, Iss 9, Pp 1408-1415 (2024)
Vision is closely tied to quality of life. Traditional drug delivery routes for clinical therapy of key ocular diseases, such as glaucoma, are topical and systemic administrations, which are less invasive but often face some physiological barriers su
Externí odkaz:
https://doaj.org/article/6e63fe7514564999804d4b1e97a36d9b
Publikováno v:
Frontiers in Veterinary Science, Vol 11 (2024)
Externí odkaz:
https://doaj.org/article/4e844b850dce43b7add98d9e1898ffc9
Publikováno v:
Frontiers in Veterinary Science, Vol 11 (2024)
Physiologically Based Pharmacokinetic (PBPK) models can provide forecasts of the drug residues within the organism. Ractopamine (RAC) is a typical β-agonist. In this study, we developed a PBPK model for RAC in goats. The goal was to predict the dist
Externí odkaz:
https://doaj.org/article/f7a730e9aed144e6900cf85902f677fd
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
BackgroundParkinson’s disease psychosis (PDP) is a common and distressing complication of Parkinson’s disease (PD), characterized by hallucinations and delusions. This research aimed to assess the pharmacokinetics and safety of NH130, a selective
Externí odkaz:
https://doaj.org/article/27cf86ff44954fdeb3d0f5edf77681e3
Autor:
Alexey S. Kolbin, Kseniya S. Radaeva
Publikováno v:
Вопросы современной педиатрии, Vol 22, Iss 4, Pp 289-297 (2023)
Drug dosing remains one of the topical issues of modern pediatrics. Insufficient number of clinical studies, vulnerable patient populations (preterm newborns, patients with renal and/or hepatic insufficiency, obesity), and high risk of polypragmasy c
Externí odkaz:
https://doaj.org/article/345c5c6042d9426892356a8a888cd279
Autor:
Mahnoor Pasha, Ammara Zamir, Muhammad Fawad Rasool, Hamid Saeed, Tanveer Ahmad, Nawaf Shalih Alqahtani, Lamya Saif Alqahtani, Faleh Alqahtani
Publikováno v:
Pharmaceuticals, Vol 17, Iss 7, p 924 (2024)
Physiologically based pharmacokinetic (PBPK) modeling is of great importance in the field of medicine. This study aims to construct a PBPK model, which can provide reliable drug pharmacokinetic (PK) predictions in both healthy and chronic kidney dise
Externí odkaz:
https://doaj.org/article/147a217e22424ea594c618ccd4f2c699
Autor:
Yun-Ting Zhang, Huihui Bao, Lei Zhang, Sheng Wen, Weihong Tan, Mohammed Zeeshan, Ming-Kun Sun, Chu Chu, Zhao-Huan Gui, Li-Zi Lin, Ru-Qing Liu, Xiao-Wen Zeng, Yunjiang Yu, Guang-Hui Dong
Publikováno v:
Hygiene and Environmental Health Advances, Vol 7, Iss , Pp 100066- (2023)
Background: Health risk assessment based on epidemiological data for perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) are evidenced. Whereas information about health-based guidance values (HBGVs) and health risk for Chinese populati
Externí odkaz:
https://doaj.org/article/25b2744b23fa4bccac819c79e406ef6b
Publikováno v:
Pharmaceuticals, Vol 17, Iss 3, p 369 (2024)
The objectives of this study were to support dose selection of a novel FXR agonist XZP-5610 in first-in-human (FIH) trials and to predict its liver concentrations in Chinese healthy adults. Key parameters for extrapolation were measured using in vitr
Externí odkaz:
https://doaj.org/article/d88d612b660a4940867355db6b26b600
Publikováno v:
Pharmaceutics, Vol 16, Iss 2, p 234 (2024)
Hepatic carboxylesterase 1 (CES1) metabolizes numerous prodrugs into active ingredients or direct-acting drugs into inactive metabolites. We aimed to develop a semi-physiologically based pharmacokinetic (semi-PBPK) model to simultaneously predict the
Externí odkaz:
https://doaj.org/article/3098fdbacc1a444d972ba9d31911a1b4