HO-1 Limits the Efficacy of Vemurafenib/PLX4032 in BRAFV600E Mutated Melanoma Cells Adapted to Physiological Normoxia or Hypoxia

Autor: Anna Lisa Furfaro, Giulia Loi, Caterina Ivaldo, Mario Passalacqua, Gabriella Pietra, Giovanni Enrico Mann, Mariapaola Nitti

Publikováno v: Antioxidants, Vol 11, Iss 6, p 1171 (2022)

Induction of heme oxygenase 1 (HO-1) favors immune-escape in BRAFV600 melanoma cells treated with Vemurafenib/PLX4032 under standard cell culture conditions. However, the oxygen tension under standard culture conditions (~18 kPa O2) is significantly

Externí odkaz: https://doaj.org/article/1affae77ce5e44549d3f30919a187b1a

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Defining physiological normoxia for improved translation of cell physiology to animal models and humans

Autor: Giovanni E. Mann, Thomas P. Keeley

Publikováno v: Keeley, T P & Mann, G E 2019, ' Defining physiological normoxia for improved translation of cell physiology to animal models and humans ', Physiological Reviews, vol. 99, no. 1, pp. 161-234 . https://doi.org/10.1152/physrev.00041.2017

The extensive oxygen gradient between the air we breathe (Po2~21 kPa) and its ultimate distribution within mitochondria (as low as ~0.5–1 kPa) is testament to the efforts expended in limiting its inherent toxicity. It has long been recognized that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6783e962fd328a102f50267329917387
https://kclpure.kcl.ac.uk/ws/files/95246731/Accepted_Physiololgical_Reviews_Invited_Review_Keeley_Mann_102086_2_merged_1525452472.pdf

Reduced SERCA activity underlies dysregulation of Ca

Autor: Thomas P, Keeley, Richard C M, Siow, Ron, Jacob, Giovanni E, Mann

Publikováno v: The FASEB Journal

Unregulated increases in cellular Ca2+ homeostasis are a hallmark of pathophysiological conditions and a key trigger of cell death. Endothelial cells cultured under physiologic O2 conditions (5% O2) exhibit a reduced cytosolic Ca2+ response to stimul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3a5bb318b48d78ead2e964e56a9fe382
https://pubmed.ncbi.nlm.nih.gov/29273673