Differences in Toxic Response Induced by Three Variants of the Diarrheic Shellfish Poisoning Phycotoxins in Human Intestinal Epithelial Caco-2 Cells

Autor: Antoine Huguet, Hélène Quenault, Valérie Fessard, Fanny Rousselet, Olivia Drapeau

Publikováno v: Toxins
Toxins, MDPI, 2020, 12 (12), pp.783. ⟨10.3390/toxins12120783⟩
Volume 12
Issue 12
Toxins, Vol 12, Iss 783, p 783 (2020)

International audience; Diarrheic shellfish poisoning (DSP) is caused by the consumption of shellfish contaminated with a group of phycotoxins that includes okadaic acid (OA), dinophysistoxin-1 (DTX-1), and dinophysistoxin-2 (DTX-2). These toxins are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ff23e1744da06c733c311b5ae98b75b
http://europepmc.org/articles/PMC7764622

Benchmark dose analyses of γH2AX and pH3 endpoints for quantitative comparison of in vitro genotoxicity potential of lipophilic phycotoxins

Autor: Ludovic Le Hégarat, Alain-Claude Roudot, Valérie Fessard

Publikováno v: Mutation Research/Genetic Toxicology and Environmental Mutagenesis
Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 2020, 852, pp.503169. ⟨10.1016/j.mrgentox.2020.503169⟩

International audience; The phycotoxins, okadaic acid (OA) and dinophysistoxins 1 and 2 (DTX-1 and -2), are protein phosphatase PP2A and PP1 inhibitors involved in diarrhetic shellfish poisoning (DSP) in humans. Data on the in vivo acute toxicity of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d14eea4213df081077d4fcde7682708
https://pubmed.ncbi.nlm.nih.gov/32265043

Metabolism of the lipophilic phycotoxin 13-Desmethylspirolide C using human and rat in vitro liver models

Autor: Antoine Huguet, Alfonso Lampen, Ludovic Le Hégarat, Valérie Fessard, Albert Braeuning, Jimmy Alarcan, Stefanie Hessel-Pras, Françoise Brée, Estelle Dubreil, Dominique Hurtaud-Pessel, Rómulo Aráoz, Belkacem Bouaita

Publikováno v: Toxicology Letters
Toxicology Letters, Elsevier, 2019, 307, pp.17-25. ⟨10.1016/j.toxlet.2019.02.012⟩
Toxicology Letters, 2019, 307, pp.17-25. ⟨10.1016/j.toxlet.2019.02.012⟩

International audience; 13-Desmethylspirolide C (13-SPX-C) is a phycotoxin produced by dinoflagellates which can accumulate in shellfish. 13-SPX-C induces neurotoxic effects in rodents through blockade of nicotinic acetylcholine receptors. As no huma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2fe306e01358988ebb016cb07fc8a7c
https://hal-anses.archives-ouvertes.fr/anses-02083152/document

Metabolism of the Marine Phycotoxin PTX-2 and Its Effects on Hepatic Xenobiotic Metabolism: Activation of Nuclear Receptors and Modulation of the Phase I Cytochrome P450

Autor: Ludovic Le Hégarat, Dominique Hurtaud-Pessel, Antoine Huguet, Valérie Fessard, Stefanie Hessel-Pras, Alfonso Lampen, Estelle Dubreil, Jimmy Alarcan

Publikováno v: Toxins
Toxins, MDPI, 2017, 9 (7), pp.673-673. ⟨10.1016/j.ab.2006.04.046⟩
Toxins, Vol 9, Iss 7, p 212 (2017)
Toxins; Volume 9; Issue 7; Pages: 212

International audience; PTX-2 is a marine biotoxin frequently found in shellfish that can lead to food intoxication in humans. Information regarding PTX-2 metabolism is scarce, and little is known of its effect on xenobiotic-metabolizing enzymes (XME

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2260844f2933153cb29ede71e33ccf2
https://hal-anses.archives-ouvertes.fr/anses-01570019

Combined Effects of Lipophilic Phycotoxins (Okadaic Acid, Azapsiracid-1 and Yessotoxin) on Human Intestinal Cells Models

Autor: Pierre-Jean Ferron, Ludovic Le Hégarat, Kevin Dumazeau, Valérie Fessard, Jean-François Beaulieu

Publikováno v: Toxins
Toxins, MDPI, 2016, 8 (2), pp.50-63. ⟨10.3390/toxins8020050⟩
Toxins; Volume 8; Issue 2; Pages: 50
Toxins, Vol 8, Iss 2, p 50 (2016)

International audience; Phycotoxins are monitored in seafood because they can cause food poisonings in humans. Phycotoxins do not only occur singly but also as mixtures in shellfish. The aim of this study was to evaluate the in vitro toxic interactio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49161bb531919933695edb7aa2ec80b2
https://hal-anses.archives-ouvertes.fr/anses-01333030