Zobrazeno 1 - 10
of 706
pro vyhledávání: '"photoreceptor degeneration"'
Autor:
Davide Colaianni, Federico Virga, Annamaria Tisi, Chiara Stefanelli, Germana Zaccagnini, Paola Cusumano, Gabriele Sales, Mihai Bogdan Preda, Fabio Martelli, Daniela Taverna, Massimiliano Mazzone, Cristiano Bertolucci, Rita Maccarone, Cristiano De Pittà
Publikováno v:
Biology Direct, Vol 19, Iss 1, Pp 1-19 (2024)
Abstract Background miR-210 is one of the most evolutionarily conserved microRNAs. It is known to be involved in several physiological and pathological processes, including response to hypoxia, angiogenesis, cardiovascular diseases and cancer. Recent
Externí odkaz:
https://doaj.org/article/8828cdabc7ee40a6a4825708719e2d96
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-20 (2024)
Abstract Activated microglia play an important role in driving photoreceptor degeneration-associated neuroinflammation in the retina. Controlling pro-inflammatory activation of microglia holds promise for mitigating the progression of photoreceptor d
Externí odkaz:
https://doaj.org/article/f777bac59272469c80103d81f901536c
Autor:
Kuanxiang Sun, Lu Liu, Xiaoyan Jiang, Heting Wang, Lin Wang, Yeming Yang, Wenjing Liu, Lin Zhang, Xiaohui Zhao, Xianjun Zhu
Publikováno v:
Genes and Diseases, Vol 11, Iss 2, Pp 1035-1049 (2024)
The endoplasmic reticulum (ER) membrane protein complex (EMC) is responsible for monitoring the biogenesis and synthetic quality of membrane proteins with tail-anchored or multiple transmembrane domains. The EMC subunit EMC6 is one of the core member
Externí odkaz:
https://doaj.org/article/38196c1721994bb3ae8ae8bb43ab0309
Autor:
Kasim Gunes, Karen Chang, Anton Lennikov, Wai Lydia Tai, Julie Chen, Farris ElZaridi, Kin-Sang Cho, Tor Paaske Utheim, Chen Dong Feng
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
IntroductionThe potential neuroprotective and regenerative properties of electrical stimulation (ES) were studied in rhodopsin knockout mice (Rho−/−), a murine model of inherited retinal degeneration. The study focused on assessing the impact of
Externí odkaz:
https://doaj.org/article/0ae625ffcc364309a5b97827f25dc833
Publikováno v:
Disease Models & Mechanisms, Vol 17, Iss 7 (2024)
Externí odkaz:
https://doaj.org/article/2552e55609d44f88920526ff4f1c8c6e
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 2, Pp 102176- (2024)
Retinal neovascularization (RNV) is primarily driven by vascular endothelial growth factor (VEGF). However, current anti-VEGF therapies are limited by short half-lives and repeated injections, which reduce patient quality of life and increase medical
Externí odkaz:
https://doaj.org/article/61fa65ed1d6348539fd3acd8f6a1b6d0
Autor:
Sam Enayati, Karen Chang, Anton Lennikov, Menglu Yang, Cherin Lee, Ajay Ashok, Farris Elzaridi, Christina Yen, Kasim Gunes, Jia Xie, Kin-Sang Cho, Tor Paaske Utheim, Dong Feng Chen
Publikováno v:
Neural Regeneration Research, Vol 19, Iss 11, Pp 2543-2552 (2024)
Retinitis pigmentosa is a hereditary retinal disease that affects rod and cone photoreceptors, leading to progressive photoreceptor loss. Previous research supports the beneficial effect of electrical stimulation on photoreceptor survival. This study
Externí odkaz:
https://doaj.org/article/2c8efc2702d941ef8c1a490a026008cb
Autor:
Diego García-Ayuso, Johnny Di Pierdomenico, Ana Martínez-Vacas, Manuel Vidal-Sanz, Serge Picaud, María P Villegas-Pérez
Publikováno v:
Neural Regeneration Research, Vol 19, Iss 3, Pp 606-610 (2024)
Taurine is considered a non-essential amino acid because it is synthesized by most mammals. However, dietary intake of taurine may be necessary to achieve the physiological levels required for the development, maintenance, and function of certain tis
Externí odkaz:
https://doaj.org/article/a7a9178a15e04afb82ed176ed8cce0f4
Autor:
Jiefang Wang, Xinting Liu, Jing Huang, Ruoyun Deng, Sijun Zhao, Yulei Chen, Zhaohe Chen, Yanli Wang, Yu Rong, Qian Liu, Jia Qu, Xinjie Mao
Publikováno v:
Frontiers in Neuroscience, Vol 18 (2024)
PurposeTo investigate the contrast sensitivity function (CSF) changes in simple high myopia (SHM) and evaluate the correlations between these changes with the early changes in the retinal microstructure.MethodsThis prospective study comprised 81 subj
Externí odkaz:
https://doaj.org/article/29ccefcff255451bb15c39f96bdbea99
Autor:
Daijin Li, Jing Xu, Jie Chang, Yujue Wang, Xiaoye Du, Hanhan Wu, Jingang Cui, Peiwei Wang, Teng Zhang, Yu Chen
Publikováno v:
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-22 (2023)
Abstract Background Photoreceptor degeneration underpinned by oxidative stress-mediated mitochondrial dysfunction and cell death leads to progressive and irreversible vision impairment. Drug treatments that protect against photoreceptor degeneration
Externí odkaz:
https://doaj.org/article/baf21c19b7844314a6c94ce9acb526c6