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Light-Activating PROTACs in Cancer: Chemical Design, Challenges, and Applications

Autor: Arvind Negi, Kavindra Kumar Kesari, Anne Sophie Voisin-Chiret

Publikováno v: Applied Sciences, Vol 12, Iss 19, p 9674 (2022)

Nonselective cell damage remains a significant limitation of radiation therapies in cancer. Decades of successful integration of radiation therapies with other medicinal chemistry strategies significantly improved therapeutic benefits in cancer. Adva

Externí odkaz: https://doaj.org/article/25c5c30b3d9c4c8586f16f797608aab5

Photocage-initiated time-resolved solution X-ray scattering investigation of protein dimerization

Autor: Inokentijs Josts, Stephan Niebling, Yunyun Gao, Matteo Levantino, Henning Tidow, Diana Monteiro

Publikováno v: IUCrJ, Vol 5, Iss 6, Pp 667-672 (2018)

This work demonstrates a new method for investigating time-resolved structural changes in protein conformation and oligomerization via photocage-initiated time-resolved X-ray solution scattering by observing the ATP-driven dimerization of the MsbA nu

Externí odkaz: https://doaj.org/article/1558c233344a4214ab87388e3e3647a0

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Photoactivatable Small‐Molecule Inhibitors for Light‐Controlled TAM Kinase Activity

Autor: Sandrine Piguel, Liliane Mouawad, Sophie Bombard, Thomas Boddaert, Julie Le Bescont

Publikováno v: ChemPhotoChem
ChemPhotoChem, Wiley, 2021, 5, pp.989-994. ⟨10.1002/cptc.202100131⟩
ChemPhotoChem, 2021, 5, pp.989-994. ⟨10.1002/cptc.202100131⟩

International audience; Supporting information for this article is given via a link at the end of the document.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cacc46358aee165389d961d994071b8
https://doi.org/10.1002/cptc.202100131