Mitochondrial phosphoenolpyruvate carboxykinase promotes tumor growth in estrogen receptor‐positive breast cancer via regulation of the mTOR pathway

Autor: Hui‐Ping Hsu, Pei‐Yi Chu, Tsung‐Ming Chang, Kuo‐Wei Huang, Wen‐Chun Hung, Shih Sheng Jiang, Hui‐You Lin, Hui‐Jen Tsai

Publikováno v: Cancer Medicine, Vol 12, Iss 2, Pp 1588-1601 (2023)

Abstract Background Tumor cells may aberrantly express metabolic enzymes to adapt to their environment for survival and growth. Targeting cancer‐specific metabolic enzymes is a potential therapeutic strategy. Phosphoenolpyruvate carboxykinase (PEPC

Externí odkaz: https://doaj.org/article/95aa146bb8eb4a7c8ac27962dfcfb6c6

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Assessment of Aspartate and Bicarbonate Produced From Hyperpolarized [1-13C]Pyruvate as Markers of Renal Gluconeogenesis

Autor: Hikari A. I. Yoshihara, Arnaud Comment, Juerg Schwitter

Publikováno v: Frontiers in Physiology
Frontiers in Physiology, Vol 12 (2021)

As both a consumer and producer of glucose, the kidney plays a significant role in glucose homeostasis. Measuring renal gluconeogenesis requires invasive techniques, and less invasive methods would allow renal gluconeogenesis to be measured more rout

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9401520c10ddb5fce9e3f2f3dd5dacbb

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Metabolic selection of a homologous recombination-mediated gene loss protects Trypanosoma brucei from ROS production by glycosomal fumarate reductase

Autor: Wargnies, Marion, Plazolles, Nicolas, Schenk, Robin, Villafraz, Oriana, Dupuy, Jean-William, Biran, Marc, Bachmaier, Sabine, Baudouin, Hélène, Clayton, Christine, Boshart, Michael, Bringaud, Frédéric

Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2021, 296, pp.100548. ⟨10.1016/j.jbc.2021.100548⟩
The Journal of Biological Chemistry

International audience; The genome of trypanosomatids rearranges by using repeated sequences as platforms for amplification or deletion of genomic segments. These stochastic recombination events have a direct impact on gene dosage and foster the sele

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::432b54ef02595b3c3feb09753cee04e9
https://hal.archives-ouvertes.fr/hal-03216701