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pro vyhledávání: '"phosphodiesterase 10A"'
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Publikováno v:
Asian Journal of Andrology, Vol 25, Iss 5, Pp 608-615 (2023)
Phosphodiesterase (PDE) inhibitors can improve sperm motility in patients with asthenozoospermia. However, the most commonly reported nonselective PDE inhibitor pentoxifylline and PDE5 inhibitor sildenafil have the disadvantages of requiring a high c
Externí odkaz:
https://doaj.org/article/e471b713a6c442b480c035f8fddda318
Autor:
Weizhen Wang, Juan Zhang, Honghong Hu, Baojun Yu, Jintong He, Tingting Yao, Yaling Gu, Zhengyun Cai, Guosheng Xin
Publikováno v:
Animal Bioscience, Vol 35, Iss 11, Pp 1771-1786 (2022)
Objective Inosine monophosphate (IMP) is a key factor that imparts of meat flavor. Differences in the IMP content in the muscles were evaluated to improve chicken meat quality. Methods For this study, the IMP content was detected by high performance
Externí odkaz:
https://doaj.org/article/fda6e048b60b40ca9dc01b8dc852a799
Autor:
Zhiwei Xiao, Huiyi Wei, Yi Xu, Ahmed Haider, Junjie Wei, Shiyu Yuan, Jian Rong, Chunyu Zhao, Guocong Li, Weibin Zhang, Huangcan Chen, Yuefeng Li, Lingling Zhang, Jiyun Sun, Shaojuan Zhang, Hai-Bin Luo, Sen Yan, Qijun Cai, Lu Hou, Chao Che, Steven H. Liang, Lu Wang
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 12, Iss 4, Pp 1963-1975 (2022)
As a member of cyclic nucleotide phosphodiesterase (PDE) enzyme family, PDE10A is in charge of the degradation of cyclic adenosine (cAMP) and guanosine monophosphates (cGMP). While PDE10A is primarily expressed in the medium spiny neurons of the stri
Externí odkaz:
https://doaj.org/article/dbe615a754e04340924e1a3797b18488
Autor:
Cheng Ju, Fangyu Yuan, Lu Wang, Caixia Zang, Jingwen Ning, Meiyu Shang, Jingwei Ma, Gen Li, Yang Yang, Qiuzhu Chen, Yueqi Jiang, Fangfang Li, Xiuqi Bao, Dan Zhang
Publikováno v:
Neurobiology of Disease, Vol 177, Iss , Pp 105988- (2023)
CXC chemokine receptor 2 (CXCR2) plays an important role in demyelinating diseases, but the detailed mechanisms were not yet clarified. In the present study, we mainly investigated the critical function and the potential molecular mechanisms of CXCR2
Externí odkaz:
https://doaj.org/article/455bfa5369e747b894c8870f3c0b3ba8
Autor:
Huiyi Wei, Junjie Wei, Shaojuan Zhang, Shiliang Dong, Guocong Li, Wenqing Ran, Chenchen Dong, Weibin Zhang, Chao Che, Wenzhao Luo, Hao Xu, Zhiyong Dong, Jinghao Wang, Lu Wang
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 10 (2022)
Our previous work showed that [18F]P10A-1910 was a potential radioligand for use in imaging phosphodiesterase 10A (PDE10A). Specifically, it had high brain penetration and specific binding that was demonstrated in both rodents and non-human primates.
Externí odkaz:
https://doaj.org/article/bca6d32b181045879af8a3b99b51b007
Autor:
Yuncong Yang, Sirui Zhang, Qian Zhou, Chen Zhang, Yuqi Gao, Hao Wang, Zhe Li, Deyan Wu, Yinuo Wu, Yi-You Huang, Lei Guo, Hai-Bin Luo
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 10, Iss 12, Pp 2339-2347 (2020)
Optimization efforts were devoted to discover novel PDE10A inhibitors in order to improve solubility and pharmacokinetics properties for a long-term therapy against pulmonary arterial hypertension (PAH) starting from the previously synthesized inhibi
Externí odkaz:
https://doaj.org/article/ccae75c50048476bb23a4e31a9cef74b
Autor:
Keita Arakawa, Shunsuke Maehara
Publikováno v:
Neuropsychopharmacology Reports, Vol 40, Iss 2, Pp 190-195 (2020)
Abstract Aim Phosphodiesterase 10A (PDE10A) inhibitors not only have antipsychotic‐like effects but also cause cognitive enhancement without affecting extrapyramidal side effects in rodents, suggesting that PDE10A may be a novel approach for the tr
Externí odkaz:
https://doaj.org/article/3c9a1f26816843a69973335f34b0672e
Publikováno v:
Cells, Vol 11, Iss 21, p 3385 (2022)
Papaverine (PPV), a benzylisoquinoline alkaloid, extracted from the Papaverine somniferum plant, is currently in clinical use as a vasodilator. Research has shown that PPV inhibits phosphodiesterase 10A (PDE10A,) resulting in the accumulation of cycl
Externí odkaz:
https://doaj.org/article/b3717b9c7d094bd38a0afc611aa4c410
Autor:
Rayanne Poletti Guimarães, Danilo Leandro Ribeiro, Keila Bariotto Dos Santos, Carlos Henrique Zanello Talarico, Lívea Dornela Godoy, Fernando E. Padovan-Neto
Publikováno v:
Pharmaceuticals, Vol 15, Iss 8, p 947 (2022)
The facilitation of corticostriatal transmission is modulated by the pharmacological inhibition of striatal phosphodiesterase 10A (PDE10A). Since L-DOPA-induced dyskinesia is associated with abnormal corticostriatal transmission, we hypothesized that
Externí odkaz:
https://doaj.org/article/9a298f92f97049a183e09f9f15afef92