Zobrazeno 1 - 10
of 163
pro vyhledávání: '"phosphatase and tensin homologue deleted on chromosome 10"'
Publikováno v:
Journal of Innate Immunity, Pp 1-11 (2022)
This study intends to investigate the effects of miR-142-5p encapsulated by serum-derived extracellular vesicles (EVs) on septic acute lung injury (ALI) following remote ischemic preconditioning (RIPC) through a PTEN-involved mechanism. ALI was induc
Externí odkaz:
https://doaj.org/article/48cd315a3132446f8f4828e6e9a257f0
Autor:
Chunhua Ling, Xueting Wang, Jianjie Zhu, Haicheng Tang, Wenwen Du, Yuanyuan Zeng, Lin Sun, Jian‐An Huang, Zeyi Liu
Publikováno v:
Cancer Medicine, Vol 8, Iss 7, Pp 3520-3531 (2019)
Abstract It is well‐known that phosphatase and tensin homologue deleted on chromosome 10 (PTEN) is a tumor suppressor which negatively regulates PI3K/AKT signaling and is activated widely in non‐small cell lung cancers (NSCLC). However, genetic a
Externí odkaz:
https://doaj.org/article/07775943a8064fc69dde3df034d20ef3
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Neuronal insulin resistance is implicated in neurodegenerative diseases. Icariin has been reported to improve insulin resistance in skeletal muscle cells and to restore impaired hypothalamic insulin signaling in the rats with chronic unpredictable mi
Externí odkaz:
https://doaj.org/article/971fc5d2049c49388b34467fa3b9bcdd
Publikováno v:
Biomolecules, Vol 9, Iss 1, p 29 (2019)
The phosphatidylinositol 3-kinase (PI3K) pathway plays a central role in the regulation of cell signaling, proliferation, survival, migration and vesicle trafficking in normal cells and is frequently deregulated in many cancers. The p85α protein is
Externí odkaz:
https://doaj.org/article/53583cf2741c451f9cc2a3e0212a2927
Autor:
Wenwen Du, Yuanyuan Zeng, Jianjie Zhu, Jian-An Huang, Xueting Wang, Zeyi Liu, Haicheng Tang, Chunhua Ling, Lin Sun
Publikováno v:
Cancer Medicine
Cancer Medicine, Vol 8, Iss 7, Pp 3520-3531 (2019)
Cancer Medicine, Vol 8, Iss 7, Pp 3520-3531 (2019)
It is well‐known that phosphatase and tensin homologue deleted on chromosome 10 (PTEN) is a tumor suppressor which negatively regulates PI3K/AKT signaling and is activated widely in non‐small cell lung cancers (NSCLC). However, genetic alteration
Autor:
Guangyan Yu, Yulu Huang, Yixin Zhang, Chunhua Wang, Lida Fan, Xiangfu Song, Jiayi Song, Shimeng Liu, Yixue Yang
Publikováno v:
Molecular Medicine Reports
The International Agency for Research on Cancer has classified formaldehyde (FA) as a leukemogen to humans in 2012; however, the underlying mechanism remains unclear. Phosphatase and tensin homologue deleted on chromosome 10 (PTEN) is a tumor-suppres
Autor:
Agne, Kazlauskaite, Chandana, Kondapalli, Robert, Gourlay, David G, Campbell, Maria Stella, Ritorto, Kay, Hofmann, Dario R, Alessi, Axel, Knebel, Matthias, Trost, Miratul M K, Muqit
Publikováno v:
Biochemical Journal
We have previously reported that the Parkinson's disease-associated kinase PINK1 (PTEN-induced putative kinase 1) is activated by mitochondrial depolarization and stimulates the Parkin E3 ligase by phosphorylating Ser65 within its Ubl (ubiquitin-like
Autor:
Viktoria-Konstantina Varra, Michail Varras, Aikaterini Tsavari, Aggelis Stavropoulos, Anastassios Philippou, Thivi Vasilakaki, Michael Koutsilieris, Fani-Niki Varra, Andreas C. Lazaris
Publikováno v:
Oncology Letters
Chronic hyperinsulinemia due to insulin resistance and elevated levels of insulin-like growth factor (IGF)-1 and IGF-2 are suggestive of a significantly higher risk of endometrial carcinoma. There is a wealth of evidence showing differential expressi
Publikováno v:
Experimental and Therapeutic Medicine
T cell acute lymphoblastic leukemia (T-ALL), an aggressive and heterogeneous malignancy originating from T cell precursors (thymocytes), accounts for ~15% of all ALL cases in children and for ~25% in adults. The present study aimed to investigate the
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