Zobrazeno 1 - 10
of 409
pro vyhledávání: '"phosphatase and tensin homologue"'
Publikováno v:
Guoji Yanke Zazhi, Vol 24, Iss 1, Pp 24-29 (2024)
AIM: To study the protective effect of fenofibrate on diabetic retinal neurodegeneration and observe its effect on miR-26a-5p and its target gene PTEN in the retinal of diabetic mice.METHODS: Diabetic mice models were established and they were gavage
Externí odkaz:
https://doaj.org/article/f8a4e32391ee4ee9b4336bf394c42b9b
Publikováno v:
Zhongguo quanke yixue, Vol 26, Iss 15, Pp 1909-1915 (2023)
Chronic and refractory wounds are serious complications of diabetes mellitus, and have no effective treatments. Numerous studies have confirmed that events such as inflammatory response, angiopoiesis and matrix remodeling are closely related to mitoc
Externí odkaz:
https://doaj.org/article/2ea6a1e37f29402d85a74f38d812b842
Autor:
Bei Fan, Fei Lu, Wei-Jia Du, Jun Chen, Xiao-Gang An, Ren-Feng Wang, Wei Li, Yong-Li Song, Ding-Jun Zha, Fu-Quan Chen
Publikováno v:
Neural Regeneration Research, Vol 18, Iss 7, Pp 1601-1606 (2023)
Studies have shown that phosphatase and tensin homolog deleted on chromosome ten (PTEN) participates in the regulation of cochlear hair cell survival. Bisperoxovanadium protects against neurodegeneration by inhibiting PTEN expression. However, whethe
Externí odkaz:
https://doaj.org/article/a271bc82cc2b493bb06a63b94a263500
Publikováno v:
Journal of Innate Immunity, Pp 1-11 (2022)
This study intends to investigate the effects of miR-142-5p encapsulated by serum-derived extracellular vesicles (EVs) on septic acute lung injury (ALI) following remote ischemic preconditioning (RIPC) through a PTEN-involved mechanism. ALI was induc
Externí odkaz:
https://doaj.org/article/48cd315a3132446f8f4828e6e9a257f0
Publikováno v:
环境与职业医学, Vol 39, Iss 3, Pp 331-336 (2022)
BackgroundExposure to arsenic can damage trophoblast cells and thus induce abortion, but the mechanism is not known.ObjectiveTo investigate the role of miR-145 and PTEN/AKT/mTOR pathway in arsenic-induced abortion and trophoblast cell damage in rats.
Externí odkaz:
https://doaj.org/article/63f9b3a53b4a4ab0b043b16cfe8b7139
Publikováno v:
Nanoscale Research Letters, Vol 16, Iss 1, Pp 1-13 (2021)
Abstract Objective Esophageal squamous cell carcinoma (ESCC) is featured by early metastasis and late diagnosis. MicroRNA-301 (miR-301) is known to participate in diverse cancers. Nevertheless, effects of miR-301 on ESCC remain unexplored. Thus, we a
Externí odkaz:
https://doaj.org/article/015e5ac570bc4bffac77780b9704b30b
Autor:
Bor Luen Tang
Publikováno v:
Neural Regeneration Research, Vol 15, Iss 1, Pp 10-15 (2020)
Environmental enrichment is known to be beneficial for cognitive improvement. In many animal models of neurological disorders and brain injury, EE has also demonstrated neuroprotective benefits in neurodegenerative diseases and in improving recovery
Externí odkaz:
https://doaj.org/article/1e3bb29a49f54188bf2ecb925d6edb69
Autor:
Chunhua Ling, Xueting Wang, Jianjie Zhu, Haicheng Tang, Wenwen Du, Yuanyuan Zeng, Lin Sun, Jian‐An Huang, Zeyi Liu
Publikováno v:
Cancer Medicine, Vol 8, Iss 7, Pp 3520-3531 (2019)
Abstract It is well‐known that phosphatase and tensin homologue deleted on chromosome 10 (PTEN) is a tumor suppressor which negatively regulates PI3K/AKT signaling and is activated widely in non‐small cell lung cancers (NSCLC). However, genetic a
Externí odkaz:
https://doaj.org/article/07775943a8064fc69dde3df034d20ef3
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Neuronal insulin resistance is implicated in neurodegenerative diseases. Icariin has been reported to improve insulin resistance in skeletal muscle cells and to restore impaired hypothalamic insulin signaling in the rats with chronic unpredictable mi
Externí odkaz:
https://doaj.org/article/971fc5d2049c49388b34467fa3b9bcdd
Autor:
So-Youn Kim, Takeshi Kurita
Publikováno v:
European Medical Journal, Vol 3, Iss 2, Pp 119-125 (2018)
The immature oocytes within primordial follicles are arrested at Prophase I of meiosis and remain dormant until awakened by an increase in intracellular levels of phosphatidylinositol (3,4,5)-trisphosphate (PIP3). Oocyte PIP3 level is determined by t
Externí odkaz:
https://doaj.org/article/e1a430a0a9ef49828e7278998c28c811