SPINOPHILIN: A multiplayer tumor suppressor

Autor: Eva M. Verdugo-Sivianes, Amancio Carnero

Publikováno v: Genes and Diseases, Vol 10, Iss 1, Pp 187-198 (2023)

SPINOPHILIN (SPN, PPP1R9B or NEURABIN-2) is a multifunctional protein that regulates protein–protein interactions in different cell signaling pathways. SPN is also one of the regulatory subunits of protein phosphatase 1 (PP1), implicated in the dep

Externí odkaz: https://doaj.org/article/b1bc5e3fe7ab4f5ea702d2db8d769381

Role of the Holoenzyme PP1-SPN in the Dephosphorylation of the RB Family of Tumor Suppressors During Cell Cycle

Autor: Amancio Carnero, Eva M. Verdugo-Sivianes

Publikováno v: Cancers, Vol 13, Iss 2226, p 2226 (2021)
Cancers

Simple Summary Cell cycle progression is highly regulated by modulating the phosphorylation status of retinoblastoma (RB) family proteins. This process is controlled by a balance in the action of kinases, such as the complexes formed by cyclin-depend

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::352fa573595b3b007792e2eb6a685d1d
https://www.mdpi.com/2072-6694/13/9/2226/pdf?version=1620374432

Role of the holoenzyme PP1-SPN in the dephosphorylation of the rb family of tumor suppressors during cell cycle

Autor: Verdugo Sivianes, Eva María, Carnero Moya, Amancio

Publikováno v: idUS: Depósito de Investigación de la Universidad de Sevilla
Universidad de Sevilla (US)
idUS. Depósito de Investigación de la Universidad de Sevilla
instname

Cell cycle progression is highly regulated by modulating the phosphorylation status of the retinoblastoma protein (pRB) and the other two members of the RB family, p107 and p130. This process is controlled by a balance in the action of kinases, such

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::18f552b4ebe6b405adca14ff3d39445c

Inhibition of serine/threonine protein phosphatase PP1 protects cardiomyocytes from tunicamycin-induced apoptosis and I/R through the upregulation of p-eIF2α

Autor: Kunlun He, Yun-Yun He, Ruijun Li, Chunlei Liu, Xin Li, Lili Wang

Publikováno v: International Journal of Molecular Medicine

The serine/threonine protein phosphatase PP1 mediates the dephosphorylation of phosphorylated eukaryotic translation initiation factor 2 subunit α (p-eIF2α), which is a central regulator of protein synthesis. In the present study, we examined the p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1db0a196444dcb0a9f2599655b5959d1
http://europepmc.org/articles/PMC3926518

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