A Phenylfurocoumarin Derivative Reverses ABCG2-Mediated Multidrug Resistance In Vitro and In Vivo

Autor: Shota Funayama, Norihiko Sugisawa, Shinobu Ohnuma, Kosuke Ohsawa, Akihiro Yamamura, Kuniyuki Kano, Megumi Murakami, Suresh V. Ambudkar, Takeshi Naitoh, Hideyuki Suzuki, Junken Aoki, Michiaki Unno, Shoji Kokubo, Takayuki Doi, Haruhisa Kikuchi, Hideaki Karasawa, Taiki Kajiwara

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 12502, p 12502 (2021)
Volume 22
Issue 22

The ATP-binding cassette subfamily G member 2 (ABCG2) transporter is involved in the development of multidrug resistance in cancer patients. Many inhibitors of ABCG2 have been reported to enhance the chemosensitivity of cancer cells. However, none of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daac828465dcdc6b809b612909314fbe
https://doi.org/10.3390/ijms222212502

Paynantheine more effectively reverses multidrug resistance in malignant EPG85.257RDB and MCF7MX cells than morphine and speciociliatine.

Autor: Abdali N; Department of Medical Biotechnology, School of Advanced Technologies, Shahrekord University of Medical Sciences, Shahrekord, Iran., Nadipour Borujeni M; Department of Medical Biotechnology, School of Advanced Technologies, Shahrekord University of Medical Sciences, Shahrekord, Iran., Hosseini SA; Department of Medical Biotechnology, School of Advanced Technologies, Shahrekord University of Medical Sciences, Shahrekord, Iran., Malekzadeh R; Department of Medical Biotechnology, School of Advanced Technologies, Shahrekord University of Medical Sciences, Shahrekord, Iran., Abolhasani M; Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran., Mirzaei SA; Department of Medical Biotechnology, School of Advanced Technologies, Shahrekord University of Medical Sciences, Shahrekord, Iran.; Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran., Elahian F; Department of Medical Biotechnology, School of Advanced Technologies, Shahrekord University of Medical Sciences, Shahrekord, Iran.; Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran.

Publikováno v: Cell biology international [Cell Biol Int] 2024 Jun; Vol. 48 (6), pp. 861-871. Date of Electronic Publication: 2024 Mar 13.