Zobrazeno 1 - 10
of 229
pro vyhledávání: '"phase 3 clinical trial"'
Autor:
Zhihao Lu, Li Kong, Buhai Wang, Junye Wang, Lianke Liu, Yongqian Shu, Lei Yang, Guogui Sun, Guochun Cao, Yinghua Ji, Tongjian Cui, Hu Liu, Wensheng Qiu, Na Li, Gaofeng Li, Hui Luo, Xinfang Hou, Yanqiao Zhang, Wenbin Yue, Liying Xue, Zheng Liu, Yueyin Pan, Shegan Gao, Xiuwen Wang, Zhanyu Pan, Shuqun Zhang, Gen Lin, Yanru Xie, Kangsheng Gu, Tiejun Ren, Weidong Li, Tao Li, Shoufeng Wang, Wei He, Yun Fan, Jun Liang, Bing Xia, Li Zhao, Shuxuan Wang, Lin Shen
Publikováno v:
EClinicalMedicine, Vol 72, Iss , Pp 102623- (2024)
Summary: Background: In ORIENT-15 study, sintilimab plus chemotherapy demonstrated significant improvement on overall survival (OS) versus placebo plus chemotherapy in first-line treatment of advanced esophageal squamous cell carcinoma (ESCC). Here,
Externí odkaz:
https://doaj.org/article/3439ece3dd7b46968792b2d1c86fbbe8
Autor:
Daniela Rivera-Pérez, Constanza Méndez, Benjamín Diethelm-Varela, Felipe Melo-González, Yaneisi Vázquez, Xing Meng, Qianqian Xin, Rodrigo A. Fasce, Jorge Fernández, Judith Mora, Eugenio Ramirez, Mónica L. Acevedo, Fernando Valiente-Echeverría, Ricardo Soto-Rifo, Alba Grifoni, Daniela Weiskopf, Alessandro Sette, Patricio Astudillo, Nicole Le Corre, Katia Abarca, Cecilia Perret, Pablo A. González, Jorge A. Soto, Susan M. Bueno, Alexis M. Kalergis
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundVaccine effectiveness against SARS-CoV-2 infection has been somewhat limited due to the widespread dissemination of the Omicron variant, its subvariants, and the immune response dynamics of the naturally infected with the virus.MethodsTwelv
Externí odkaz:
https://doaj.org/article/7c001b5b42b5457faed5b3a10f22f0e2
Autor:
Caroline R. Perry, Nicole E. Scangarella-Oman, Helen Millns, William Flight, Sally Gatsi, Charles Jakielaszek, Salim Janmohamed, David A. Lewis
Publikováno v:
Infectious Diseases and Therapy, Vol 12, Iss 9, Pp 2307-2320 (2023)
Abstract Introduction Gonorrhea, caused by Neisseria gonorrhoeae (NG), is the second most common bacterial sexually transmitted infection (STI). Rates of antimicrobial resistance to standard care are increasing worldwide, with many antibiotic classes
Externí odkaz:
https://doaj.org/article/cc36ad392f934716b949adc17100ac8c
Autor:
Binghe Xu, Qingyuan Zhang, Xichun Hu, Qing Li, Tao Sun, Wei Li, Quchang Ouyang, Jingfen Wang, Zhongsheng Tong, Min Yan, Huiping Li, Xiaohua Zeng, Changping Shan, Xian Wang, Xi Yan, Jian Zhang, Yue Zhang, Jiani Wang, Liang Zhang, Ying Lin, Jifeng Feng, Qianjun Chen, Jian Huang, Lu Zhang, Lisong Yang, Ying Tian, Hongyan Shang
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 13, Iss 5, Pp 2250-2258 (2023)
Entinostat plus exemestane in hormone receptor-positive (HR+) advanced breast cancer (ABC) previously showed encouraging outcomes. This multicenter phase 3 trial evaluated the efficacy and safety of entinostat plus exemestane in Chinese patients with
Externí odkaz:
https://doaj.org/article/29416e726eef485fb5be6cf4325c42c0
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Background: The regimens of immune checkpoint inhibitors (ICIs) alone or with chemotherapy are emerging as systemic therapy for patients with advanced and metastatic gastrointestinal cancers. However, the risk of treatment-related hematologic toxicit
Externí odkaz:
https://doaj.org/article/9265dffd70d24bc0ba934a2cdb11042f
Autor:
Sally A. Hulton, Jaap W. Groothoff, Yaacov Frishberg, Michael J. Koren, J. Scott Overcash, Anne-Laure Sellier-Leclerc, Hadas Shasha-Lavsky, Jeffrey M. Saland, Wesley Hayes, Daniella Magen, Shabbir H. Moochhala, Martin Coenen, Eva Simkova, Sander F. Garrelfs, David J. Sas, Kristin A. Meliambro, Taylor Ngo, Marianne T. Sweetser, Bahru A. Habtemariam, John M. Gansner, Tracy L. McGregor, John C. Lieske
Publikováno v:
Kidney International Reports, Vol 7, Iss 3, Pp 494-506 (2022)
Introduction: Primary hyperoxaluria type 1 (PH1) is a rare genetic disease caused by hepatic overproduction of oxalate, leading to kidney stones, nephrocalcinosis, kidney failure, and systemic oxalosis. In the 6-month double-blind period (DBP) of ILL
Externí odkaz:
https://doaj.org/article/d1c32da830c840358e1a339f45ee8a45
Autor:
Jorge A. Soto, Felipe Melo-González, Cristián Gutierrez-Vera, Bárbara M. Schultz, Roslye V. Berríos-Rojas, Daniela Rivera-Pérez, Alejandro Piña-Iturbe, Guillermo Hoppe-Elsholz, Luisa F. Duarte, Yaneisi Vázquez, Daniela Moreno-Tapia, Mariana Ríos, Pablo A. Palacios, Richard Garcia-Betancourt, Álvaro Santibañez, Gaspar A. Pacheco, Constanza Mendez, Catalina A. Andrade, Pedro H. Silva, Benjamín Diethelm-Varela, Patricio Astudillo, Mario Calvo, Antonio Cárdenas, Marcela González, Macarena Goldsack, Valentina Gutiérrez, Marcela Potin, Andrea Schilling, Lorena I. Tapia, Loreto Twele, Rodolfo Villena, Alba Grifoni, Alessandro Sette, Daniela Weiskopf, Rodrigo A. Fasce, Jorge Fernández, Judith Mora, Eugenio Ramírez, Aracelly Gaete-Argel, Mónica L. Acevedo, Fernando Valiente-Echeverría, Ricardo Soto-Rifo, Angello Retamal-Díaz, Nathalia Muñoz-Jofré, Xing Meng, Qianqian Xin, Eduardo Alarcón-Bustamante, José V. González-Aramundiz, Nicole Le Corre, María Javiera Álvarez-Figueroa, Pablo A. González, Katia Abarca, Cecilia Perret, Leandro J. Carreño, Susan M. Bueno, Alexis M. Kalergis
Publikováno v:
mBio, Vol 13, Iss 6 (2022)
ABSTRACT Multiple vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been evaluated in clinical trials. However, trials addressing the immune response in the pediatric population are scarce. The inactivated vaccine Cor
Externí odkaz:
https://doaj.org/article/cf113e0121754f51995644752d348004
Autor:
Nicolás MS Gálvez, Gaspar A Pacheco, Bárbara M Schultz, Felipe Melo-González, Jorge A Soto, Luisa F Duarte, Liliana A González, Daniela Rivera-Pérez, Mariana Ríos, Roslye V Berrios, Yaneisi Vázquez, Daniela Moreno-Tapia, Omar P Vallejos, Catalina A Andrade, Guillermo Hoppe-Elsholz, Carolina Iturriaga, Marcela Urzua, María S Navarrete, Álvaro Rojas, Rodrigo Fasce, Jorge Fernández, Judith Mora, Eugenio Ramírez, Aracelly Gaete-Argel, Mónica L Acevedo, Fernando Valiente-Echeverría, Ricardo Soto-Rifo, Daniela Weiskopf, Alba Grifoni, Alessandro Sette, Gang Zeng, Weining Meng, CoronaVacCL03 Study Group, José V González-Aramundiz, Marina Johnson, David Goldblatt, Pablo A González, Katia Abarca, Susan M Bueno, Alexis M Kalergis
Publikováno v:
eLife, Vol 11 (2022)
Background: The development of vaccines to control the coronavirus disease 2019 (COVID-19) pandemic progression is a worldwide priority. CoronaVac is an inactivated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine approved for eme
Externí odkaz:
https://doaj.org/article/ac762f639ff7488791e3508152fce059
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Autor:
Frontiers Production Office
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Externí odkaz:
https://doaj.org/article/03ad016ec5e34cb295f5b972d855247e