Zobrazeno 1 - 10
of 2 211
pro vyhledávání: '"phase 2"'
Autor:
Burhan Engin, Müge Güler Özden, Özge Sevil Karstarlı Bakay, Selda Pelin Kartal, İlkin Zindancı, Salih Levent Çınar, Recep Dursun, Gizem Pehlivan Ulutaş, Tuğba Özkök Özkök Akbulut, Fatma Aslı Hapa, Emel Bülbül Başkan, Mehmet Melikoğlu, Algün Polat Ekinci, Neslihan Demirel Öğüt, Pelin Hızlı, Zafer Türkoğlu, Özlem Su Küçük, Zeynep Topkarcı, Ümit Türsen, Filiz Canpolat, Hanife Uçgun, Şirin Yaşar, Selami Aykut Temiz, Asena Çiğdem Doğramacı, Sedat Altuğ, Serhat Kozlu, Nadir Ulu, Server Serdaroğlu
Publikováno v:
Dermatology and Therapy, Vol 14, Iss 12, Pp 3337-3350 (2024)
Abstract Introduction Topical therapies are used in almost all patients with psoriasis. A novel fixed topical combination cream (GN-037) with a lower concentration (0.0356%) of clobetasol 17-propionate (CP) was developed together with urea, salicylic
Externí odkaz:
https://doaj.org/article/cf42627b9f3d43dca5ccaa56fabba82d
Autor:
Ghassan K. Abou-Alfa, Tim Meyer, Richard Kinh Gian Do, Sarina A. Piha-Paul, Joseph S. Light, Scott Sherrin, Amin Yaqubie, Alison Clemens O’Neill, James J. Harding, Raed Al-Rajabi, Crystal S. Denlinger, Pablo Cano, Albert S. Cornelius, Eileen M. O'Reilly, Daniel DiPrimeo, Lisa D. Eli, John D. Gordan, David B. Solit
Publikováno v:
Liver Cancer, Pp 1-10 (2024)
Introduction: Fibrolamellar carcinoma (FLC) displays upregulation of several oncogenes, including HER2, and multiple immune-suppressive mechanisms. We investigated the efficacy and safety of the pan-HER tyrosine kinase inhibitor neratinib as monother
Externí odkaz:
https://doaj.org/article/060277f2d7054affa161c9c60698ca95
Autor:
Maria Pilar Ruiz Seco, José Ramón Paño Pardo, Christian Schoergenhofer, Christiane Dings, Thorsten Lehr, Felix Herth, Andriy Krendyukov, Carola Straub, Martin Kappler, Bernd Jilma, Harald Fricke, Julian Pardo, Diego de Miguel, Meinolf Thiemann, Michael Bergmann, Henning Walczak, Thomas Hoeger
Publikováno v:
EClinicalMedicine, Vol 77, Iss , Pp 102879- (2024)
Summary: Background: The phase 2 ASUNCTIS study assessed the efficacy and safety of asunercept, a fully human CD95 (Fas) ligand-binding protein, in hospitalised patients with moderate-to-severe coronavirus disease (COVID-19) to assess the clinical be
Externí odkaz:
https://doaj.org/article/f34a85026187404385bbd167989aeaf9
Autor:
Yukari Okubo, Tadashi Terui, Satomi Kobayashi, Shigetoshi Sano, Akimichi Morita, Shinichi Imafuku, Yayoi Tada, Masatoshi Abe, Masafumi Yaguchi, Takeshi Kimura, Junichiro Shimauchi, Wendy Zhang, Hamid Amouzadeh, Masamoto Murakami
Publikováno v:
Dermatology and Therapy, Vol 14, Iss 7, Pp 1863-1873 (2024)
Abstract Introduction Palmoplantar pustulosis (PPP) is a pruritic, painful, chronic dermatitis that greatly impacts functioning and quality of life and can be difficult to treat. Approved treatment options for PPP are limited, and many patients do no
Externí odkaz:
https://doaj.org/article/34a2089061c64c6f827972a89c82714f
Autor:
Jinlin Hou, Edward Gane, Rozalina Balabanska, Wenhong Zhang, Jiming Zhang, Tien Huey Lim, Qing Xie, Chau-Ting Yeh, Sheng-Shun Yang, Xieer Liang, Piyawat Komolmit, Apinya Leerapun, Zenghui Xue, Ethan Chen, Yuchen Zhang, Qiaoqiao Xie, Ting-Tsung Chang, Tsung-Hui Hu, Seng Gee Lim, Wan-Long Chuang, Barbara Leggett, Qingyan Bo, Xue Zhou, Miriam Triyatni, Wen Zhang, Man-Fung Yuen
Publikováno v:
Clinical and Molecular Hepatology, Vol 30, Iss 2, Pp 191-205 (2024)
Background/Aims Four-week treatment of linvencorvir (RO7049389) was generally safe and well tolerated, and showed anti-viral activity in chronic hepatitis B (CHB) patients. This study evaluated the efficacy, safety, and pharmacokinetics of 48-week tr
Externí odkaz:
https://doaj.org/article/aeead632d03142ec95bc4b04123f5c17
Autor:
Hiroo Imai, Yasuhiro Sakamoto, Shin Takahashi, Hiroyuki Shibata, Atsushi Sato, Kazunori Otsuka, Kenji Amagai, Masanobu Takahashi, Takuhiro Yamaguchi, Chikashi Ishioka
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-8 (2024)
Abstract Background Advanced pancreatic cancer is one of the leading causes of cancer-related deaths. For patients with advanced pancreatic cancer, gemcitabine and nanoparticle albumin-binding paclitaxel (nabPTX) combination (GEM/nabPTX) therapy is o
Externí odkaz:
https://doaj.org/article/5310443217344e7f9c587dac657eb026
Autor:
Eko Setiawan, Wahyu Ade Fitriani
Publikováno v:
Journal of Natural Resources and Environmental Management, Vol 14, Iss 2 (2024)
Wonogiri Regency, located in Indonesia, is an area susceptible to various types of natural disasters, such as floods, landslides, and hurricanes, which pose a significant risk to approximately 90% in this area. Therefore, this study aimed to identify
Externí odkaz:
https://doaj.org/article/cbaea94b3ae04a19895de2b02aec8dc3
Autor:
Benjamin D. Ehst, Bruce Strober, Andrew Blauvelt, Douglas Maslin, Debbie Macaro, Nancy Carpenter, Mark Bodmer, Duncan McHale
Publikováno v:
Frontiers in Medicine, Vol 11 (2024)
BackgroundPsoriasis is a chronic inflammatory skin disease. EDP1815 is an oral, gut-restricted preparation of non-live Prevotella histicola, the first of a new immunomodulatory therapeutic class targeting the small intestine to generate systemic anti
Externí odkaz:
https://doaj.org/article/5fd2330275af40a3a093c784b86539ee
Autor:
Howard Trachtman, Matthias Kretzler, Hailey E. Desmond, Wansuk Choi, Raymond C. Manuel, Nima Soleymanlou
Publikováno v:
Kidney International Reports, Vol 8, Iss 12, Pp 2822-2825 (2023)
Externí odkaz:
https://doaj.org/article/7d2ce554e6144d519f8547492ad6b5f7
Autor:
Ligorio, Francesca 1, 2, 14, Vingiani, Andrea 3, 4, 14, Torelli, Tommaso 4, Sposetti, Caterina 1, 3, Drufuca, Lorenzo 2, Iannelli, Fabio 5, Zanenga, Lucrezia 1, Depretto, Catherine 6, Folli, Secondo 7, Scaperrotta, Gianfranco 6, Capri, Giuseppe 1, Bianchi, Giulia V. 1, Ferraris, Cristina 7, Martelli, Gabriele 7, Maugeri, Ilaria 7, Provenzano, Leonardo 1, 3, Nichetti, Federico 1, Agnelli, Luca 4, Lobefaro, Riccardo 1, Fucà, Giovanni 1, Fotia, Giuseppe 1, Mariani, Luigi 8, Morelli, Daniele 4, Ladisa, Vito 9, De Santis, Maria Carmen 6, Lozza, Laura 6, Trecate, Giovanna 6, Belfiore, Antonino 4, Brich, Silvia 4, Bertolotti, Alessia 4, Lorenzini, Daniele 3, 4, Ficchì, Angela 1, Martinetti, Antonia 1, Sottotetti, Elisa 1, Arata, Alessio 1, Corsetto, Paola 10, Sorrentino, Luca 7, Rediti, Mattia 2, Salvadori, Giulia 2, Minucci, Saverio 3, 11, Foiani, Marco 2, 3, Apolone, Giovanni 12, Pagani, Massimiliano 2, 13, Pruneri, Giancarlo 3, 4, 15, de Braud, Filippo 1, 3, 15, Vernieri, Claudio 1, 2, 15, 16, ∗
Publikováno v:
In Cell Metabolism November 2024