Adenosine A1 receptor antagonist rolofylline alleviates axonopathy caused by human Tau ΔK280

Autor: Marta Anglada-Huguet, Eva-Maria Mandelkow, Frank J.A. Dennissen, Astrid Sydow, Eckhard Mandelkow

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America 113(41), 11597-11602 (2016). doi:10.1073/pnas.1603119113
Proceedings of the National Academy of Sciences of the United States of America

Accumulation of Tau is a characteristic hallmark of several neurodegenerative diseases but the mode of toxic action of Tau is poorly understood. Here, we show that the Tau protein is toxic due to its aggregation propensity, whereas phosphorylation an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b52f81b47d2ed21ccae4ce84b6953bd
https://europepmc.org/articles/PMC5068267/