Zobrazeno 1 - 6
of 6
pro vyhledávání: '"pharmacology [Thiazines]"'
Autor:
Tanja Blume, Severin Filser, Etienne Herzog, Jochen Herms, Mario M. Dorostkar, Finn Peters, Derya R. Shimshek, Nils Brose, Hazal Salihoglu, Eva Ferreira Rodrigues, Ulf Neumann
Publikováno v:
Acta Neuropathologica
Acta Neuropathologica, Springer Verlag, 2018, 135 (5), pp.695-710. ⟨10.1007/s00401-017-1804-9⟩
Acta Neuropathologica (Berl)
Acta neuropathologica 135(5), 695-710 (2018). doi:10.1007/s00401-017-1804-9
Acta Neuropathologica, Springer Verlag, 2018, 135 (5), pp.695-710. ⟨10.1007/s00401-017-1804-9⟩
Acta Neuropathologica (Berl)
Acta neuropathologica 135(5), 695-710 (2018). doi:10.1007/s00401-017-1804-9
BACE1 is the rate-limiting protease in the production of synaptotoxic β-amyloid (Aβ) species and hence one of the prime drug targets for potential therapy of Alzheimer’s disease (AD). However, so far pharmacological BACE1 inhibition failed to res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af044c91d1bf50ef951bb3c095454513
https://doi.org/10.1007/s00401-017-1804-9
https://doi.org/10.1007/s00401-017-1804-9
Autor:
Nina Jährling, Angelos Skodras, Mathias Jucker, Bettina M. Wegenast-Braun, Stephan A. Kaeser, Daniel Eicke, Hans-Ulrich Dodt, Ulrike Obermueller, David P. Wolfer, Derya R. Shimshek, Thomas Mueggler, Matthias Staufenbiel, Sarah K. Fritschi, Juliane Schelle, Lisa M. Häsler, Natalie Beschorner, Ulf Neumann
Publikováno v:
Annals of neurology 86(4), 561-571 (2019). doi:10.1002/ana.25562
Objective Clinical trials targeting β-amyloid peptides (Aβ) for Alzheimer disease (AD) failed for arguable reasons that include selecting the wrong stages of AD pathophysiology or Aβ being the wrong target. Targeting Aβ to prevent cerebral amyloi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b84045137144faa99c754e085815120
https://www.zora.uzh.ch/id/eprint/173281/
https://www.zora.uzh.ch/id/eprint/173281/
Autor:
Hugo Vanderstichele, Derya R. Shimshek, Stephan A. Kaeser, Mathias Jucker, Juliane Schelle, Jens C. Göpfert, Matthias Staufenbiel, Erik Stoops, Eva-Maria Mandelkow, Lisa M. Häsler, Thomas O. Joos, Ulf Neumann
Publikováno v:
Alzheimer's and dementia 13(6), 701-709 (2017). doi:10.1016/j.jalz.2016.09.005
Alzheimer's and Dementia
Alzheimer's and Dementia
Introduction The inhibition of the β-site amyloid precursor protein-cleaving enzyme 1 (BACE1) is a main therapeutic approach for the treatment of Alzheimer's disease (AD). We previously reported an age-related increase of tau protein in the cerebros
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b80e3a98c39c265443e8e1638197c64
https://pub.dzne.de/record/139312
https://pub.dzne.de/record/139312
Autor:
Karen Beltz, Carine Kolly, Ludovic Perrot, Laurent Morawiec, Laura H. Jacobson, Juliane Schelle, Diethilde Theil, Barbara Bertschi, Robert Kreutzer, Mathias Jucker, Kamal Kumar Balavenkatraman, Derya R. Shimshek, Irena Brzak, Ulf Neumann, Karine Bigot, Natasa Zamurovic, Annabelle Heier, Rainer Machauer
Publikováno v:
Scientific reports 6(1), 21917 (2016). doi:10.1038/srep21917
Scientific Reports
Scientific Reports
Melanocytes of the hair follicle produce melanin and are essential in determining the differences in hair color. Pigment cell-specific MELanocyte Protein (PMEL17) plays a crucial role in melanogenesis. One of the critical steps is the amyloid-like fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b19920ee6601981c02e87f33e3ae00e
https://doi.org/10.1038/srep21917
https://doi.org/10.1038/srep21917
Autor:
Mercè Masana, Marianne B. Müller, Christian K.E. Jung, Lidia Blazquez-Llorca, Christiane Volbracht, Anders Brandt Elvang, Saak V. Ovsepian, Jochen Herms, Severin Filser
Publikováno v:
Biological psychiatry 77(8), 729-739 (2015). doi:10.1016/j.biopsych.2014.10.013
Background BACE1 (beta site amyloid precursor protein cleaving enzyme 1) is the rate limiting protease in amyloid β production, hence a promising drug target for the treatment of Alzheimer's disease. Inhibition of BACE1, as the major β-secretase in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb421afb016d5a65583de63e68321280
https://pub.dzne.de/record/137858
https://pub.dzne.de/record/137858
Autor:
Sabina Tahirovic, Annika Wulf-Goldenberg, Christian Haass, Cyril Cheret, Paul Saftig, Florence R. Fricker, Alistair N. Garratt, Carmen Birchmeier, Hagen Wende, Michael Willem, Klaus-Armin Nave, David L.H. Bennett
Publikováno v:
The EMBO Journal
The EMBO journal 32(14), 2015-2028 (2013). doi:10.1038/emboj.2013.146
The EMBO journal 32(14), 2015-2028 (2013). doi:10.1038/emboj.2013.146
The protease β-secretase 1 (Bace1) was identified through its critical role in production of amyloid-β peptides (Aβ), the major component of amyloid plaques in Alzheimer's disease. Bace1 is considered a promising target for the treatment of this p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eacd5357a8fcb5c20b9ee2cb77c09aaf
https://hdl.handle.net/21.11116/0000-000D-3620-211858/00-001M-0000-0029-26BC-9
https://hdl.handle.net/21.11116/0000-000D-3620-211858/00-001M-0000-0029-26BC-9