Výsledky vyhledávání - "pharmacology [Tetrodotoxin]"

The role of Nav1.7 in human nociceptors: insights from human induced pluripotent stem cell-derived sensory neurons of erythromelalgia patients

Publikováno v: Pain
Pain : the journal of the International Association for the Study of Pain 160(6), 1327-1341 (2019). doi:10.1097/j.pain.0000000000001511
Pain 160(6), 1327-1341 (2019). doi:10.1097/j.pain.0000000000001511

Supplemental Digital Content is Available in the Text. Human sodium channel NaV1.7 in induced pluripotent stem cell–derived sensory neurons sets the action potential threshold but does not support subthreshold depolarizations.
The chronic pain

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80927ffc3692702b91e7f7a576388aec
https://pubmed.ncbi.nlm.nih.gov/30720580

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Neurotrophin receptor p75 mediates the uptake of the amyloid beta (Aβ) peptide, guiding it to lysosomes for degradation in basal forebrain cholinergic neurons

Autor: Inga Antyborzec, Valerie B. O'Leary, J. Oliver Dolly, Saak V. Ovsepian, Laszlo Zaborszky, Jochen Herms

Publikováno v: Brain structure & function 219(5), 1527-1541 (2013). doi:10.1007/s00429-013-0583-x

A fascinating yet perhaps overlooked trait of the p75 neurotrophin receptor (p75(NTR)) is its ability to bind ligands with no obvious neurotrophic function. Using cultured basal forebrain (BF) neurons, this study demonstrates selective internalizatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27c0b743b2ba9c6e9d9b218209022c3c
https://doi.org/10.1007/s00429-013-0583-x

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Dendritic backpropagation and synaptic plasticity in the mormyrid electrosensory lobe

Autor: Yoshiko Sugawara, E. van de Burg, Shun-ichi Kuwana, Kirsty Grant, Jacob Engelmann, Joao Bacelo, M. de Ruijters

Publikováno v: Journal of Physiology-Paris. 102:233-245

This study is concerned with the origin of backpropagating action potentials in GABAergic, medium ganglionic layer neurones (MG-cells) of the mormyrid electrosensory lobe (ELL). The characteristically broad action potentials of these neurones are req

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac2f6376e285c27b5e7a4591c9176f36
https://doi.org/10.1016/j.jphysparis.2008.10.004

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Circadian- and Light-Dependent Regulation of Resting Membrane Potential and Spontaneous Action Potential Firing of Drosophila Circadian Pacemaker Neurons

Autor: Vivek Sharma, Diane K. O'Dowd, Vasu Sheeba, Todd C. Holmes, Huaiyu Gu

Publikováno v: Sheeba, Vasu; Gu, Huaiyu; Sharma, Vijay K; O'Dowd, Diane K; & Holmes, Todd C. (2008). Circadian-and light-dependent regulation of resting membrane potential and spontaneous action potential firing of Drosophila circadian pacemaker neurons.. Journal of neurophysiology, 99(2), 976-988. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/5w287772

The ventral lateral neurons (LNvs) of adult Drosophila brain express oscillating clock proteins and regulate circadian behavior. Whole cell current-clamp recordings of large LNvs in freshly dissected Drosophila whole brain preparations reveal two spo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7263cb99e04dde85ac5de3c00b709f0c
https://doi.org/10.1152/jn.00930.2007

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Downregulation of Spermine Augments Dendritic Persistent Sodium Currents and Synaptic Integration after Status Epilepticus

Autor: Albert J. Becker, Susanne Schoch, Heinz Beck, Anne Woitecki, Tony Kelly, Thoralf Opitz, David M. Otte, Julika Pitsch, Michel Royeck, Ulrich Benjamin Kaupp, Andreas Rennhack, Yoel Yaari, Andreas Zimmer

Publikováno v: The journal of neuroscience 35(46), 15240-15253 (2015). doi:10.1523/JNEUROSCI.0493-15.2015

Dendritic voltage-gated ion channels profoundly shape the integrative properties of neuronal dendrites. In epilepsy, numerous changes in dendritic ion channels have been described, all of them due to either their altered transcription or phosphorylat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3ed454b97966ab8020c772c8fee6fb7
https://pub.dzne.de/record/138257

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Drosophila mushroom body Kenyon cells generate spontaneous calcium transients mediated by PLTX-sensitive calcium channels

Autor: Jiang, Shaojuan Amy, Campusano, Jorge M, Su, Hailing, O'Dowd, Diane K

Publikováno v: Jiang, Shaojuan Amy; Campusano, Jorge M; Su, Hailing; & O'Dowd, Diane K. (2005). Drosophila mushroom body Kenyon cells generate spontaneous calcium transients mediated by PLTX-sensitive calcium channels.. Journal of neurophysiology, 94(1), 491-4500. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/4cf5h7vw

Spontaneous calcium oscillations in mushroom bodies of late stage pupal and adult Drosophila brains have been implicated in memory consolidation during olfactory associative learning. This study explores the cellular mechanisms regulating calcium dyn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::76281479e87d0a24c1a452f2fa083750
http://www.escholarship.org/uc/item/4cf5h7vw

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Formation of functional synaptic connections between cultured cortical neurons from agrin-deficient mice

Autor: Martin A. Smith, Lutz G.W. Hilgenberg, Diane K. O'Dowd, Zhen Li

Publikováno v: Li, Zhen; Hilgenberg, Lutz G.W.; O'Dowd, Diane K; & Smith, Martin A. (1999). Formation of functional synaptic connections between cultured cortical neurons from agrin-deficient mice.. Journal of neurobiology, 39(4), 547-557. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/0wd8d8c5

Numerous studies suggest that the extracellular matrix protein agrin directs the formation of the postsynaptic apparatus at the neuromuscular junction (NMJ). Strong support for this hypothesis comes from the observation that the high density of acety

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b29e6df527db779dd6f7fbcafb173f68
http://www.escholarship.org/uc/item/0wd8d8c5

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Influences of tetrodotoxin, amiloride, phenytoin, aconitine, tetraethylammonium on ACTH-an isoproterenol-mediated lipolysis in isolated rat adipocytes

Autor: Paolo Nencini, V. Pasquarelli

The effects of tetrodotoxin, amiloride, phenytoin, aconitine, and tetraethylammonium on isoproterenol- and ACTH-mediated Free Fatty Acids (FFA) and glycerol release from rat adipocytes are investigated in order to understand more about the role of Na

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49880553cbac79d471bd6ce3d7542776
http://hdl.handle.net/11573/452728

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