Výsledky vyhledávání - "pharmacology [Small Molecule Libraries]"

Small organic molecules accelerate the expansion of regulatory T cells

Autor: Xiaoming Zhang, Shafiullah Khan, Muhammad Waqar Hameed, Saifullah Afridi, Abdul Wajid Khalil, Musarrat Adnan, Jamshed Iqbal, M. A. Shahid, Daniel C. Hoessli, Zhiyuan Wu, Zafar Iqbal

Publikováno v: Bioorganic chemistry 111, 104908-(2021). doi:10.1016/j.bioorg.2021.104908

The regulatory T cells (Treg cells) expressing CD4 + CD25 + FOXP3 + markers are indispensable for the initiation of immune homeostasis and tolerance to self-antigens in both mice and humans. A decrease in regulatory T cells leads to various autoimmun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ac5b1c329494176c9b4d583a1757389
https://pub.dzne.de/record/155992

Zobrazit plný text záznamu

Generalizing the Concept of Specific Compound Formulation Additives towards Non-Fluorescent Drugs: A Solubilization Study on Potential Anti-Alzheimer-Active Small-Molecule Compounds

Autor: Hans G. Börner, Carmen Lawatscheck, Eckhard Mandelkow, Marcus Pickhardt, Sebastian Wieczorek, Andrea Grafmüller

Publikováno v: Angewandte Chemie, International Edition in English
Angewandte Chemie / International edition 55(30), 8752-8756 (2016). doi:10.1002/anie.201601147

Tailor-made compound formulation additives enable the testing of potential drugs with undesirable pharmacological profiles. A combinatorial approach using Raman microscopy as the readout method is presented to select peptide sequences from large one-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4add26881a5b134de0fe10472761f5c1
https://doi.org/10.1002/anie.201601147

Zobrazit plný text záznamu

A high-content screen for small-molecule regulators of epithelial cell-adhesion molecule (EpCAM) cleavage yields a robust inhibitor

Autor: Harald Steiner, Kamyar Hadian, Elke Luxenburger, Olivier Gires, Dierk Niessing, Johannes Trambauer, Kenji Schorpp, Jana Ylva Tretter

Publikováno v: The journal of biological chemistry 293(23), 8994-9005 (2018). doi:10.1074/jbc.RA118.002776
J. Biol. Chem. 293, 8994-9005 (2018)

Epithelial cell-adhesion molecule (EpCAM) is a transmembrane protein that regulates cell cycle progression and differentiation and is overexpressed in many carcinomas. The EpCAM-induced mitogenic cascade is activated via regulated intramembrane prote

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::879c307fdd2b4345d5cd8f3dd0f15c59
https://europepmc.org/articles/PMC5995519/

Zobrazit plný text záznamu

Small Molecules Detected by Second-Harmonic Generation Modulate the Conformation of Monomeric α-Synuclein and Reduce Its Aggregation in Cells

Autor: Guowei Yin, Karin Giller, Markus Zweckstetter, Tiago F. Outeiro, Timo Strohäker, Francesca Munari, Joshua Salafsky, Ben Moree, Diana F. Lázaro, Stefan Becker

Publikováno v: Journal of Biological Chemistry
The Journal of Biological Chemistry
The journal of biological chemistry 290(46), 27582-27593 (2015). doi:10.1074/jbc.M114.636027

Background: α-Synuclein aggregation is associated with Parkinson disease. Results: Small molecules were identified by second-harmonic generation (SHG) that change α-synuclein conformation in vitro and reduce the aggregation of protein in cells. Con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e94d4e41f529440ed17d7b805a1a18ab
https://doi.org/10.1074/jbc.m114.636027

Zobrazit plný text záznamu

Selective activators of protein phosphatase 5 target the autoinhibitory mechanism

Autor: Gerd Gemmecker, Martin Helmuth, Julia M. Eckl, Michael Groll, Werner Schmidt, Gunter Fischer, Matthias Weiwad, Ferdinand Alte, Adrian Drazic, Veronika Haslbeck, Frank Striggow, Klaus Richter, Frank Braun, Michael Sattler, Grzegorz M Popowicz

Publikováno v: Bioscience Reports
Bioscience reports 35(3), e00210 (2015). doi:10.1042/BSR20150042
Biosci. Rep. 35:e00210 (2015)

This paper describes the identification of compounds, which stimulate the activity of the protein phosphatase PPH-5 and addresses the influence of the identified compounds on the enzymatic properties and the potential mechanism of their action.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f88a5dbea1f41f00e3e4d55d448ad050
https://mediatum.ub.tum.de/1342574

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání